Ir/Zn Dual Catalysis: Enantioselective and Diastereodivergent α-Allylation of Unprotected α-Hydroxy Indanones

A one-step enantioselective and diastereqclivergent alpha-allylation unprotected alpha-hydroxy indanones has been developed using an Ir/Zn dual catalyst system; no additIonal base is required. The cyclic tertiary alpha-hydroxyketones containing vicinal stereocenters can be synthesized with excellent enantioselectivity (up to. >99% ee) and good diastereoselectiyity (up to 12:1,dr). By a simple choice of the appropriate chiral metal catalyst combination, all four product stereoisomers could be obtained from the same starling materials and under identical conditions.