The Evolution of the Total Synthesis of Rocaglamide

Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine

(2016) Qian Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

(2016) Shintaro Iwasaki et al.   NATURE

Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities

(2016) Midori A. Arai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Each Enantiomer of Rocaglamide by Means of a Palladium(0)-Catalyzed Nazarov-Type Cyclization

(2015) Zhe Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Palladium(0)-Catalyzed Nazarov-Type Cyclization

(2015) Kei Kitamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Nazarov Cyclization: Construction of Vicinal All-Carbon-Atom Quaternary Stereocenters

(2014) Anais Jolit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

(2014) Bill C. Hawkins et al.   ChemMedChem

The Nazarov Cyclization: A Valuable Method to Synthesize Fully Substituted Carbon Stereocenters

(2014) Donald R. Wenz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Biomimetic Kinetic Resolution: Highly Enantio- and Diastereoselective Transfer Hydrogenation of Aglain Ketones To Access Flavagline Natural Products

(2014) Steven D. Stone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nazarov-like cyclization reactions

(2014) Martin J. Di Grandi   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Determination of the Absolute Configuration of Cavicularin by a Symmetrization/Asymmetrization Approach

(2013) Hiromu Takiguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond the Divinyl Ketone: Innovations in the Generation and Nazarov Cyclization of Pentadienyl Cation Intermediates

(2013) William T. Spencer III et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

(2013) Takayuki Kogure et al.   PLoS One

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

Total Synthesis of (−)-Quinocarcin by Gold(I)-Catalyzed Regioselective Hydroamination

(2012) Hiroaki Chiba et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Formal Synthesis of (±)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction

(2012) Philip Magnus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Magnesiation or Zincation of Highly Functionalized Alkenes and Cycloalkenes Using 2,2,6,6-Tetramethylpiperidyl Bases

(2011) Tomke Bresser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Catalytic Enantioselective Total Synthesis of (+)-Liphagal

(2011) Joshua J. Day et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Nazarov Cyclization: The State of the Art

(2011) Tulaza Vaidya et al.   ChemCatChem

Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

(2011) Paul A. Wender et al.   Nature Chemistry

Asymmetric Nazarov cyclizations

(2011) Naoyuki Shimada et al.   TETRAHEDRON

Pushing the limits of steric demand around a biaryl axis: synthesis of tetra-ortho-substituted biaryl naphthalenes

(2010) Adam C. Glass et al.   CHEMICAL COMMUNICATIONS

Novel Flavaglines Displaying Improved Cytotoxicity

(2010) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A

(2010) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interrupting the Nazarov reaction: domino and cascade processes utilizing cyclopentenyl cations

(2009) Tina N. Grant et al.   CHEMICAL COMMUNICATIONS

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

(2009) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of the Potent Anticancer Aglaia Metabolites (−)-Silvestrol and (−)-Episilvestrol and the Active Analogue (−)-4′-Desmethoxyepisilvestrol

(2009) Tim E. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nazarov Cyclization Initiated by Peracid Oxidation: The Total Synthesis of (±)-Rocaglamide

(2009) John A. Malona et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Total Synthesis and Biological Activity of (±)-Rocaglamide and Its 2,3-Di-epi Analogue

(2008) Hongsen Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY