Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine

Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction

(2016) Jie Han et al.   INFLAMMATORY BOWEL DISEASES

Synthesis of Each Enantiomer of Rocaglamide by Means of a Palladium(0)-Catalyzed Nazarov-Type Cyclization

(2015) Zhe Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel carbocationic rearrangements of 1-styrylpropargyl alcohols

(2015) Christine Basmadjian et al.   Beilstein Journal of Organic Chemistry

Assessment of flavaglines as potential chikungunya virus entry inhibitors

(2015) Phitchayapak Wintachai et al.   MICROBIOLOGY AND IMMUNOLOGY

Exploratory studies toward a synthesis of flavaglines. A novel access to a highly substituted cyclopentenone intermediate

(2015) Christine Basmadjian et al.   TETRAHEDRON LETTERS

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway

(2014) Fathi Emhemmed et al.   BIOCHEMICAL PHARMACOLOGY

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

(2014) Bill C. Hawkins et al.   ChemMedChem

Biomimetic Kinetic Resolution: Highly Enantio- and Diastereoselective Transfer Hydrogenation of Aglain Ketones To Access Flavagline Natural Products

(2014) Steven D. Stone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of Stress Response Pathways Promotes Formation of Antiviral Granules and Restricts Virus Replication

(2014) D. K. Rozelle et al.   MOLECULAR AND CELLULAR BIOLOGY

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

(2014) Li Pan et al.   NATURAL PRODUCT REPORTS

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

Cancer wars: natural products strike back

(2014) Christine Basmadjian et al.   Frontiers in Chemistry

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A

(2013) Christine Basmadjian et al.   Future Medicinal Chemistry

Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II

(2013) Jennifer M. Chambers et al.   ORGANIC LETTERS

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

(2013) Zeina Nasr et al.   BMC Pharmacology & Toxicology

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Flavaglines as Potent Anticancer and Cytoprotective Agents

(2012) Nigel Ribeiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors

(2012) Tao Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of 2‴,5‴-Diepisilvestrol and Its C1‴ Epimer: Key Structure Activity Relationships at C1‴ and C2‴

(2012) Jennifer M. Chambers et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of (±)-Rocaglamide via Oxidation-Initiated Nazarov Cyclization

(2012) John A. Malona et al.   JOURNAL OF ORGANIC CHEMISTRY

Formal Synthesis of (±)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction

(2012) Philip Magnus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in the biology and chemistry of the flavaglines

(2011) Nigel Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies

(2011) Christina M. Rodrigo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

(2011) Yohann Bernard et al.   PLoS One

Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

(2010) Stéphane P. Roche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Flavaglines Displaying Improved Cytotoxicity

(2010) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

(2009) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of the Potent Anticancer Aglaia Metabolites (−)-Silvestrol and (−)-Episilvestrol and the Active Analogue (−)-4′-Desmethoxyepisilvestrol

(2009) Tim E. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nazarov Cyclization Initiated by Peracid Oxidation: The Total Synthesis of (±)-Rocaglamide

(2009) John A. Malona et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Biological Activity of (±)-Rocaglamide and Its 2,3-Di-epi Analogue

(2008) Hongsen Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY