Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential

(2017) Elisabetta Tosti et al.   Marine Drugs

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

(2017) Weiyun Huang et al.   Protein & Cell

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Binary architecture of the Nav1.2-β2 signaling complex

(2016) Samir Das et al.   eLife

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Sodium Channel β Subunits: Emerging Targets in Channelopathies

(2015) Heather A. O'Malley et al.   Annual Review of Physiology

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures

(2015) Makiko Saitoh et al.   EPILEPSY RESEARCH

The hitchhiker’s guide to the voltage-gated sodium channel galaxy

(2015) Christopher A. Ahern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity

(2014) Brad R Green et al.   Future Medicinal Chemistry

Crystal Structure and Molecular Imaging of the NavChannel β3 Subunit Indicates a Trimeric Assembly

(2014) Sivakumar Namadurai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Targeted capture and sequencing for detection of mutations causing early onset epileptic encephalopathy

(2013) Hirofumi Kodera et al.   EPILEPSIA

Clinical spectrum of SCN2A mutations expanding to Ohtahara syndrome

(2013) K. Nakamura et al.   NEUROLOGY

SCN2A Mutation Is Associated With Infantile Spasms and Bitemporal Glucose Hypometabolism

(2013) Senthil K. Sundaram et al.   PEDIATRIC NEUROLOGY

Crystallographic insights into sodium-channel modulation by the  4 subunit

(2013) J. Gilchrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

(2013) Anirban Banerjee et al.   eLife

Distinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels

(2012) Keith K. Khoo et al.   BIOCHEMISTRY

Identification of the Cysteine Residue Responsible for Disulfide Linkage of Na+Channel α and β2 Subunits

(2012) Chunling Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Interactions of Key Charged Residues Contributing to Selective Block of Neuronal Sodium Channels by  -Conotoxin KIIIA

(2011) J. R. McArthur et al.   MOLECULAR PHARMACOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY