Research Progress of Ferroptosis in Adiposity-Based Chronic Disease (ABCD)

COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

(2022) Mi Yang et al.   JOURNAL OF HEPATOLOGY

PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer

(2021) Ting Hong et al.   Redox Biology

Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis

(2021) Bing Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting SLC3A2 subunit of system XC− is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma

(2021) Lifang Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer

(2021) Yi Gou et al.   JOURNAL OF MEDICINAL CHEMISTRY

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18

(2021) Guangming Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition

(2021) Liguo Liu et al.   CANCER LETTERS

Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11

(2021) Xinbo Wang et al.   CANCER RESEARCH

A cascaded copper-based nanocatalyst by modulating glutathione and cyclooxygenase-2 for hepatocellular carcinoma therapy

(2021) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

(2021) Jingjing Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

(2021) Qianjin Zhang et al.   LIFE SCIENCES

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

(2021) Wei Gao et al.   Molecular Oncology

SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury

(2021) Jinpeng Gao et al.   NEUROREPORT

Novel function of fluvastatin in attenuating oxidized low‑density lipoprotein‑induced endothelial cell ferroptosis in a glutathione peroxidase4‑ and cystine‑glutamate antiporter‑dependent manner

(2021) Qing Li et al.   Experimental and Therapeutic Medicine

SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer

(2021) Shunv Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death

(2021) Omkar Zilka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder

(2021) Hongrui Guo et al.   Redox Biology

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

(2021) Xueying Ren et al.   Redox Biology

Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

(2020) Yiqiu Li et al.   Cancers

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

(2020) Dandan Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity

(2020) Xiaoya Li et al.   LIVER INTERNATIONAL

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes

(2020) Nian Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

(2020) Michelle Riegman et al.   NATURE CELL BIOLOGY

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

(2020) Dan Li et al.   Nutrients

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease

(2020) Yuwei Yang et al.   TOXICOLOGY

Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

(2020) Ying Jin et al.   Journal of Molecular Cell Biology

The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function

(2020) Lifang Ma et al.   Redox Biology

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

(2019) Yufei Wang et al.   EMBO REPORTS

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

A Proposal of the European Association for the Study of Obesity to Improve the ICD-11 Diagnostic Criteria for Obesity Based on the Three Dimensions Etiology, Degree of Adiposity and Health Risk

(2017) Johannes Hebebrand et al.   Obesity Facts

MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion

(2017) Yadong Wu et al.   Cancer Medicine

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation

(2016) Hong Xin et al.   ANTIOXIDANTS & REDOX SIGNALING

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

(2015) Lalage A. Katunga et al.   Molecular Metabolism

Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11

(2014) R. M. Drayton et al.   CLINICAL CANCER RESEARCH

MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

(2011) Xiao-Xiao Liu et al.   FEBS LETTERS