The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function

The N 6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma

(2020) Alexander Strick et al.   BJU INTERNATIONAL

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

(2020) Dan Jin et al.   Molecular Cancer

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

(2020) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

(2020) Jiazhen Wang et al.   Cell Stem Cell

Proteome-wide Interrogation of Small GTPases Regulated by N6-Methyladenosine Modulators

(2020) Yen-Yu Yang et al.   ANALYTICAL CHEMISTRY

Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability

(2020) Zijie Zhang et al.   NATURE GENETICS

Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA

(2020) Clayton B Woodcock et al.   NUCLEIC ACIDS RESEARCH

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

(2019) Seungwon Yang et al.   Nature Communications

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

(2019) Qiang Wang et al.   GUT

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

(2019) Ben Yue et al.   Molecular Cancer

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

(2019) Wen Ni et al.   Molecular Cancer

YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma

(2019) Jiajie Hou et al.   Molecular Cancer

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5

(2019) Yi Zhang et al.   Molecular Cancer

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g

(2018) Xiaoli Cai et al.   CANCER LETTERS

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

(2018) Sigrid Ottestad-Hansen et al.   GLIA

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

(2017) Pranavi Koppula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

(2017) Magdalena Natalia Wojtas et al.   MOLECULAR CELL

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase

(2017) Christina Hoffmann et al.   Oxidative Medicine and Cellular Longevity

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Reactive oxygen species in redox cancer therapy

(2015) Lingying Tong et al.   CANCER LETTERS

The 2015 World Health Organization Classification of Lung Tumors

(2015) William D. Travis et al.   Journal of Thoracic Oncology

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype

(2013) Kyuichi Kadota et al.   MODERN PATHOLOGY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Translating cancer 'omics' to improved outcomes

(2012) E. A. Vucic et al.   GENOME RESEARCH

Prognostic Significance of Predominant Histologic Pattern and Nuclear Grade in Resected Adenocarcinoma of the Lung: Potential Parameters for a Grading System

(2012) Jan H. von der Thüsen et al.   Journal of Thoracic Oncology

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Response and Resistance to NF- B Inhibitors in Mouse Models of Lung Adenocarcinoma

(2011) W. Xue et al.   Cancer Discovery

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE