Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death

Temperature-Dependent Effects of Alkyl Substitution on Diarylamine Antioxidant Reactivity

(2021) Ron Shah et al.   JOURNAL OF ORGANIC CHEMISTRY

Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress

(2020) Xiaowen Shi et al.   NEUROSCIENCE RESEARCH

Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals

(2020) Jia-Fei Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development and Application of a Peroxyl Radical Clock Approach for Measuring Both Hydrogen-Atom Transfer and Peroxyl Radical Addition Rate Constants

(2020) Quynh Do et al.   JOURNAL OF ORGANIC CHEMISTRY

Mitochondrial metabolism promotes adaptation to proteotoxic stress

(2019) Peter Tsvetkov et al.   Nature Chemical Biology

Predicting Octanol–Water Partition Coefficients: Are Quantum Mechanical Implicit Solvent Models Better than Empirical Fragment-Based Methods?

(2019) Varun Kundi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Neuroprotective effect of CuATSM on neurotoxin-induced motor neuron loss in an ALS mouse model

(2019) Michael T.H. Kuo et al.   NEUROBIOLOGY OF DISEASE

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Ligand-Assisted Metal-Centered Electrocatalytic Hydrogen Evolution upon Reduction of a Bis(thiosemicarbazonato)Ni(II) Complex

(2018) Rahul Jain et al.   INORGANIC CHEMISTRY

Metal-Assisted Ligand-Centered Electrocatalytic Hydrogen Evolution upon Reduction of a Bis(thiosemicarbazonato)Cu(II) Complex

(2017) Andrew Z. Haddad et al.   INORGANIC CHEMISTRY

Lipid Peroxidation: Kinetics, Mechanisms, and Products

(2017) Zosia A. M. Zielinski et al.   JOURNAL OF ORGANIC CHEMISTRY

Phenoxazine: A Privileged Scaffold for Radical-Trapping Antioxidants

(2017) Luke A. Farmer et al.   JOURNAL OF ORGANIC CHEMISTRY

Hydropersulfides: H-Atom Transfer Agents Par Excellence

(2017) Jean-Philippe R. Chauvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

(2016) Jared R. Williams et al.   NEUROBIOLOGY OF DISEASE

Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution

(2016) Jean-Philippe R. Chauvin et al.   Chemical Science

MN15: A Kohn–Sham global-hybrid exchange–correlation density functional with broad accuracy for multi-reference and single-reference systems and noncovalent interactions

(2016) Haoyu S. Yu et al.   Chemical Science

Radical ligand-containing single-molecule magnets

(2015) Selvan Demir et al.   COORDINATION CHEMISTRY REVIEWS

A Continuous Visible Light Spectrophotometric Approach To Accurately Determine the Reactivity of Radical-Trapping Antioxidants

(2015) Evan A. Haidasz et al.   JOURNAL OF ORGANIC CHEMISTRY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective

(2014) Keith U. Ingold et al.   CHEMICAL REVIEWS

Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

(2014) B. R. Roberts et al.   JOURNAL OF NEUROSCIENCE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

(2011) Brett M. Paterson et al.   CHEMICAL SOCIETY REVIEWS

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

(2011) P. S. Donnelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Transfer of Copper between Bis(thiosemicarbazone) Ligands and Intracellular Copper-Binding Proteins. Insights into Mechanisms of Copper Uptake and Hypoxia Selectivity

(2008) Zhiguang Xiao et al.   INORGANIC CHEMISTRY