Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritis

Mechanotransduction in osteogenesis

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Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis Requires Osteocytic TGFβ Signaling

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Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

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Osteoarthritis

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Bone marrow lesions in knee osteoarthritis: regional differences in tibial subchondral bone microstructure and their association with cartilage degeneration

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Investigating Osteocytic Perilacunar/Canalicular Remodeling

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Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis

(2019) Catherine J. M. Stapledon et al.   PLoS One

Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis

(2018) Dzenita Muratovic et al.   BONE

Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis

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Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1)

(2018) R-K. Zhang et al.   Bone & Joint Research

Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis

(2017) Tristan W. Fowler et al.   Scientific Reports

Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling

(2017) Neha S. Dole et al.   Cell Reports

Accuracy and reproducibility of mouse cortical bone microporosity as quantified by desktop microcomputed tomography

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Systemic neutralization of TGF-β attenuates osteoarthritis

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Osteocyte lacunar properties and cortical microstructure in human iliac crest as a function of age and sex

(2016) Fiona Linnea Bach-Gansmo et al.   BONE

Combined treatment with a transforming growth factor beta inhibitor (1D11) and bortezomib improves bone architecture in a mouse model of myeloma-induced bone disease

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Mechanobiology of TGFβ signaling in the skeleton

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TGF-β signalopathies as a paradigm for translational medicine

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Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

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Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-β signaling

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Effects of TGF-β1 on OPG/RANKL Expression of Cementoblasts and Osteoblasts Are Similar without Stress but Different with Mechanical Compressive Stress

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Effects of TGF-β1 on OPG/RANKL Expression of Cementoblasts and Osteoblasts Are Similar without Stress but Different with Mechanical Compressive Stress

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Structure Model Index Does Not Measure Rods and Plates in Trabecular Bone

(2015) Phil L. Salmon et al.   Frontiers in Endocrinology

Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta

(2014) Ingo Grafe et al.   NATURE MEDICINE

Osteocytic Canalicular Networks: Morphological Implications for Altered Mechanosensitivity

(2013) Petar Milovanovic et al.   ACS Nano

Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2

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Advances in the Regulation of Osteoclasts and Osteoclast Functions

(2013) B.F. Boyce   JOURNAL OF DENTAL RESEARCH

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Variation in osteocyte lacunar morphology and density in the human femur — a synchrotron radiation micro-CT study

(2012) Yasmin Carter et al.   BONE

Phenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic Zones: A Possible Pathological Role in Subchondral Bone Sclerosis

(2012) Anjali Jaiprakash et al.   International Journal of Biological Sciences

Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance

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Bone remodelling in osteoarthritis

(2012) David B. Burr et al.   Nature Reviews Rheumatology

Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients

(2012) D.D. Kumarasinghe et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro

(2011) S. Guiducci et al.   ANNALS OF THE RHEUMATIC DISEASES

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

(2011) R. Rezakhaniha et al.   Biomechanics and Modeling in Mechanobiology

ALK1 as an emerging target for antiangiogenic therapy of cancer

(2011) S. I. Cunha et al.   BLOOD

The organization of the osteocyte network mirrors the extracellular matrix orientation in bone

(2010) Michael Kerschnitzki et al.   JOURNAL OF STRUCTURAL BIOLOGY

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

(2009) Denis Couchourel et al.   ARTHRITIS AND RHEUMATISM

Simultaneous 3D visualization and quantification of murine bone and bone vasculature using micro-computed tomography and vascular replica

(2009) Philipp Schneider et al.   MICROSCOPY RESEARCH AND TECHNIQUE

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE