Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2

Structure, function and applications of carbonic anhydrase isozymes

(2012) Md. Imtaiyaz Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors

(2012) Gill Holdsworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of sclerostin adversely affects B-cell survival

(2012) Corey J Cain et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation

(2012) Hai Qing et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance

(2012) Simon Y Tang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteocyte regulation of bone mineral: a little give and take

(2012) G. J. Atkins et al.   OSTEOPOROSIS INTERNATIONAL

Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function

(2011) Olivier Leupin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism

(2011) Gerald J Atkins et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

(2011) A. Moustafa et al.   OSTEOPOROSIS INTERNATIONAL

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

(2011) Asiri R. Wijenayaka et al.   PLoS One

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats

(2010) XiaoYan Tian et al.   BONE

Osteoclastic Metabolism of 25(OH)-Vitamin D3: A Potential Mechanism for Optimization of Bone Resorption

(2010) Masakazu Kogawa et al.   ENDOCRINOLOGY

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by γ-carboxylation-dependent and -independent mechanisms

(2009) Gerald J. Atkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles

(2009) Gerald J. Atkins et al.   BIOMATERIALS

The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading

(2009) Alaa Moustafa et al.   BONE

Pro-Inflammatory Cytokines TNF-Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen-Activated Protein Kinase (MAPK)-Dependent Expression of Sclerostin in Human Osteoblasts*

(2009) Cristina Vincent et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcriptome and Proteome Analysis of Osteocytes Treated with Nitrogen-Containing Bisphosphonates

(2009) Nicoletta Bivi et al.   JOURNAL OF PROTEOME RESEARCH

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: A longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice

(2008) Wei Yao et al.   ARTHRITIS AND RHEUMATISM

Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited

(2008) Anna Teti et al.   BONE

Phenotypic Characteristics of Bone in Carbonic Anhydrase II-Deficient Mice

(2008) David S. Margolis et al.   CALCIFIED TISSUE INTERNATIONAL

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

(2008) N. Kamiya et al.   DEVELOPMENT

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone

(2008) Bart O Williams et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

(2008) G. J. Atkins et al.   OSTEOPOROSIS INTERNATIONAL

Establishment of an Osteocyte-like Cell Line, MLO-Y4

(2006) Yoichi Kato et al.   JOURNAL OF BONE AND MINERAL RESEARCH