Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury

(2017) Jian Ding et al.   Experimental and Therapeutic Medicine

Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients

(2016) Atsushi Minatani et al.   Journal of Orthopaedic Surgery and Research

Nerve Growth Factor Regulation by TNF-αand IL-1βin Synovial Macrophages and Fibroblasts in Osteoarthritic Mice

(2016) Shotaro Takano et al.   Journal of Immunology Research

Synovial macrophage-derived IL-1βregulates the calcitonin receptor in osteoarthritic mice

(2015) S. Takano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Staurosporine induces chondrogenesis of chick embryo wing bud mesenchyme in monolayer cultures through canonical and non-canonical TGF-β pathways

(2015) Hyoin Kim et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

(2015) E.N. Blaney Davidson et al.   OSTEOARTHRITIS AND CARTILAGE

Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy

(2015) S. Larsson et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and Safety of Intravenous Tanezumab for the Symptomatic Treatment of Osteoarthritis: 2 Randomized Controlled Trials versus Naproxen

(2014) E. F. Ekman et al.   JOURNAL OF RHEUMATOLOGY

Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain

(2014) Emilie Pecchi et al.   ARTHRITIS RESEARCH & THERAPY

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

The epidemiology and impact of pain in osteoarthritis

(2013) T. Neogi   OSTEOARTHRITIS AND CARTILAGE

Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2012) Mark T. Brown et al.   JOURNAL OF PAIN

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study

(2011) H. Nagashima et al.   OSTEOARTHRITIS AND CARTILAGE

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

(2010) Kay E. McNamee et al.   PAIN

Transforming growth factor-β induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway

(2009) Stephan L. Haas et al.   GROWTH FACTORS

Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis

(2009) Christian Barthel et al.   ARTHRITIS RESEARCH & THERAPY