A novel spinal neuron connection for heat sensation

STING controls nociception via type I interferon signalling in sensory neurons

(2021) Christopher R. Donnelly et al.   NATURE

Sensory Symphonies: How Excitatory Spinal Cord Modules Orchestrate Behavior

(2021) Mark A. Gradwell et al.   NEURON

A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

(2021) Zizhen Yao et al.   CELL

Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons

(2021) Racheli Wercberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuregulin 1 and ErbB4 Kinase Actively Regulate Sharp Wave Ripples in the Hippocampus

(2021) Heath L. Robinson et al.   JOURNAL OF NEUROSCIENCE

A harmonized atlas of mouse spinal cord cell types and their spatial organization

(2021) Daniel E. Russ et al.   Nature Communications

Anti–PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates

(2020) Zilong Wang et al.   Science Translational Medicine

The Sensory Coding of Warm Perception

(2020) Ricardo Paricio-Montesinos et al.   NEURON

Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons

(2020) Behrang Sharif et al.   NEURON

A Functional Topographic Map for Spinal Sensorimotor Reflexes

(2020) Graziana Gatto et al.   NEURON

Spinal somatostatin-positive interneurons transmit chemical itch

(2019) Mahar Fatima et al.   PAIN

Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch

(2019) Haili Pan et al.   NEURON

Expression of Neuropeptide FF Defines a Population of Excitatory Interneurons in the Superficial Dorsal Horn of the Mouse Spinal Cord that Respond to Noxious and Pruritic Stimuli

(2019) Maria Gutierrez-Mecinas et al.   NEUROSCIENCE

CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation

(2019) Zhaoqi Dong et al.   NEURON

Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons

(2019) Junichi Hachisuka et al.   PAIN

Spinal Circuits for Touch, Pain, and Itch

(2018) Stephanie C. Koch et al.   Annual Review of Physiology

Regulation of synapse development byVgatdeletion from ErbB4-positive interneurons

(2018) Thiri W. Lin et al.   JOURNAL OF NEUROSCIENCE

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Circuit dissection of the role of somatostatin in itch and pain

(2018) Jing Huang et al.   NATURE NEUROSCIENCE

Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents

(2018) Zhibing Tan et al.   NEURON

Sensory Afferents Use Different Coding Strategies for Heat and Cold

(2018) Feng Wang et al.   Cell Reports

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections

(2018) Yuanyuan Liu et al.   NATURE

Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn

(2018) Allen C. Dickie et al.   PAIN

Identifying the pathways required for coping behaviours associated with sustained pain

(2018) Tianwen Huang et al.   NATURE

Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice

(2018) Hongsheng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal nociceptive circuit analysis with recombinant adeno-associated viruses: the impact of serotypes and promoters

(2017) Karen Haenraets et al.   JOURNAL OF NEUROCHEMISTRY

A craniofacial-specific monosynaptic circuit enables heightened affective pain

(2017) Erica Rodriguez et al.   NATURE NEUROSCIENCE

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

(2017) Alice Arcourt et al.   NEURON

Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers

(2017) Hélène Beaudry et al.   PAIN

Preprotachykinin A is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli

(2017) Maria Gutierrez-Mecinas et al.   PAIN

TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity

(2017) Patrick Stemkowski et al.   Cell Reports

Transient acidosis while retrieving a fear-related memory enhances its lability

(2017) Jianyang Du et al.   eLife

Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors

(2017) William Olson et al.   eLife

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons

(2016) Qingjian Han et al.   NEURON

Immunostaining for Homer reveals the majority of excitatory synapses in laminae I–III of the mouse spinal dorsal horn

(2016) Maria Gutierrez-Mecinas et al.   NEUROSCIENCE

Neural circuits for pain: Recent advances and current views

(2016) C. Peirs et al.   SCIENCE

In Vivo Interrogation of Spinal Mechanosensory Circuits

(2016) Amelia J. Christensen et al.   Cell Reports

Semi-intact ex vivo approach to investigate spinal somatosensory circuits

(2016) Junichi Hachisuka et al.   eLife

In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP

(2016) E. C. Emery et al.   Science Advances

Hoxb8 Intersection Defines a Role for Lmx1b in Excitatory Dorsal Horn Neuron Development, Spinofugal Connectivity, and Nociception

(2015) N. E. Szabo et al.   JOURNAL OF NEUROSCIENCE

Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity

(2015) João Manuel Bráz et al.   PAIN

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

Genetic Labeling Reveals Novel Cellular Targets of Schizophrenia Susceptibility Gene: Distribution of GABA and Non-GABA ErbB4-Positive Cells in Adult Mouse Brain

(2014) J. C. Bean et al.   JOURNAL OF NEUROSCIENCE

A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments

(2014) Robert P Bonin et al.   Molecular Pain

Galanin neurons in the medial preoptic area govern parental behaviour

(2014) Zheng Wu et al.   NATURE

Normal and abnormal coding of somatosensory stimuli causing pain

(2014) Steven A Prescott et al.   NATURE NEUROSCIENCE

Peripheral thermosensation in mammals

(2014) Joris Vriens et al.   NATURE REVIEWS NEUROSCIENCE

Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory

(2014) Yisheng Lu et al.   NEURON

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing

(2013) C. Brenneis et al.   JOURNAL OF NEUROSCIENCE

Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities

(2013) Y. Xu et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Excitatory Superficial Dorsal Horn Interneurons Are Functionally Heterogeneous and Required for the Full Behavioral Expression of Pain and Itch

(2013) Xidao Wang et al.   NEURON

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold

(2013) Eric S. McCoy et al.   NEURON

Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn

(2013) Erika Polgár et al.   PAIN

Creating a False Memory in the Hippocampus

(2013) S. Ramirez et al.   SCIENCE

Theories of pain: from specificity to gate control

(2012) Massieh Moayedi et al.   JOURNAL OF NEUROPHYSIOLOGY

The Importance of the NRG-1/ErbB4 Pathway for Synaptic Plasticity and Behaviors Associated with Psychiatric Disorders

(2012) A. Shamir et al.   JOURNAL OF NEUROSCIENCE

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

A Novel Behavioral Assay for Measuring Cold Sensation in Mice

(2012) Daniel S. Brenner et al.   PLoS One

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination

(2011) Viktorija Velanac et al.   GLIA

Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway

(2011) Margarita Calvo et al.   GLIA

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Specific Regulation of NRG1 Isoform Expression by Neuronal Activity

(2011) X. Liu et al.   JOURNAL OF NEUROSCIENCE

Neuregulin 1 Promotes Excitatory Synapse Development and Function in GABAergic Interneurons

(2011) A. K. Ting et al.   JOURNAL OF NEUROSCIENCE

Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons

(2011) Guo-He Tan et al.   NATURE NEUROSCIENCE

Labeled lines meet and talk: population coding of somatic sensations

(2010) Qiufu Ma   JOURNAL OF CLINICAL INVESTIGATION

Neuregulin-ErbB Signaling Promotes Microglial Proliferation and Chemotaxis Contributing to Microgliosis and Pain after Peripheral Nerve Injury

(2010) M. Calvo et al.   JOURNAL OF NEUROSCIENCE

Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells

(2010) L. Tricoire et al.   JOURNAL OF NEUROSCIENCE

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

(2010) Pietro Fazzari et al.   NATURE

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation

(2010) Y.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Selective Expression of ErbB4 in Interneurons, But Not Pyramidal Cells, of the Rodent Hippocampus

(2009) D. Vullhorst et al.   JOURNAL OF NEUROSCIENCE

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

The subcellular organization of neocortical excitatory connections

(2009) Leopoldo Petreanu et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons

(2009) L. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

ErbB4-Neuregulin Signaling Modulates Synapse Development and Dendritic Arborization through Distinct Mechanisms

(2008) Daria Krivosheya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE

Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice

(2008) J. C. Holstege et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pbx3 is required for normal locomotion and dorsal horn development

(2007) Catherine A. Rottkamp et al.   DEVELOPMENTAL BIOLOGY