Article
Neurosciences
Nina Purg, Martina Starc, Anka Slana Ozimic, Aleksij Kraljic, Andraz Matkovic, Grega Repovs
Summary: This study compared the coding strategies used by participants in different spatial working memory tasks and found neural evidence for these strategies. Prospective motor coding was associated with increased activity in motor-related brain regions, while retrospective sensory coding was associated with increased activity in parietal regions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Kara J. Emery, Vicki J. Volbrecht, David H. Peterzell, Michael A. Webster
Summary: The coordinate frames for color and motion are often defined by three dimensions, but the organizational principles for the representation of hue and motion direction are profoundly different.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Marta Boter, Jenifer Pozas, Jose A. Jarillo, Manuel Pineiro, Monica Pernas
Summary: Elevated growth temperatures reduce crop productivity and yield losses. Modulating root traits to improve response to rising temperatures can generate new varieties better adapted to climate change. Our study identified altered root traits in Brassica napus in response to warm temperatures, resulting in an extended and deeper root system. This enhanced root growth improves root-soil interaction and increases the ability to explore soil areas. We found that changes in cell division and elongation rates, regulated by heat-shock stress response, drive root growth increases. Understanding this root response to warming temperatures can aid in improving crop yield under future climate scenarios.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Jinghui Wang, Xiaoyu Liu, Ruya Li, Yubo Fan
Summary: The achievement of artificial tactile sensory systems (ATSSs) represents a significant milestone in the advancement of human-machine interactions. However, it has been challenging for ATSSs to match the functionality of the human tactile perception system (HTPS). Biomimetic strategies and technologies inspired by HTPS offer an ideal solution to this challenge. Recent studies have focused on bioinspired approaches to enhance specific aspects of ATSS performance, such as feature collection, signal conversion, and information computation. This comprehensive review provides insights into the biomechanisms of HTPS and highlights the biomimetic strategies and technologies that contribute to the development and application of ATSSs as an integrated system.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Neurosciences
Luke Grundy, Ashlee Caldwell, Sonia Garcia-Caraballo, David Grundy, Nick J. Spencer, Xinzhong Dong, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This study demonstrates the functional expression of MrgprA3 and MrgprC11 in bladder afferents for the first time. Activation of these receptors triggers hypersensitivity to distension, which is a critically valuable factor for therapeutic target development.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Food Science & Technology
Nancy Cordoba, Fabian L. Moreno, Coralia Osorio, Sebastian Velasquez, Yolanda Ruiz
Summary: This study evaluated the effects of different roasting profiles and brewing methods on the physicochemical and sensory characteristics of coffee brews. The results showed that coffee beverages were differentiated based on the roasting profile and water temperature used in brewing. Notably, hot brewing coffees had higher acidity and furan compounds compared to cold brewing, while non-volatile extraction rate increased at higher brewing temperatures.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Thermodynamics
Md Sazan Rahman, Jingjing Han, Gaoming Ge, Md Shamim Ahamed, Huiqing Guo
Summary: Selecting the best dehumidifier for greenhouse growers is challenging due to high costs, emerging technologies, and variations in crop species, weather climate, and greenhouse sizes. This study compared the field performance of a newly developed state point liquid desiccant dehumidifier with two other commercial dehumidification technologies in ornamental and tomato greenhouses. The results showed that no single dehumidification technique was both technically effective and cost-saving year-round, highlighting the importance of combining low-cost technologies with internal dehumidification technology in cold regions.
APPLIED THERMAL ENGINEERING
(2023)
Article
Construction & Building Technology
Peng Liu, Maria Justo Alonso, Hans Martin Mathisen
Summary: Improving insulation and airtightness in buildings reduces heat losses, but ventilation energy use remains a significant concern. This study highlights the impact of longitudinal heat conduction on the efficiency of rotary heat exchangers in ventilation systems, particularly in demand-controlled ventilation. Neglecting the longitudinal heat conduction effect can lead to higher energy consumption for heating ventilation air, emphasizing the need for careful design considerations.
BUILDING AND ENVIRONMENT
(2022)
Article
Chemistry, Medicinal
Hengshuai Zhang, Xingyou Dong, Zhenxing Yang, Jiang Zhao, Qudong Lu, Jingzhen Zhu, Longkun Li, Shanhong Yi, Jie Xu
Summary: The role of CXCR4 in colon-bladder cross-organ sensitization was studied in this experiment. The results showed that treatment targeting the CXCR4/ERK pathway might provide a potential new approach for the comorbidity between the digestive system and the urinary system.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Computer Science, Artificial Intelligence
Namratha Urs, Sahar Behpour, Angie Georgaras, Mark V. Albert
Summary: This study examines neural coding strategies in sensory processing, demonstrating the efficiency of ICA in modeling early visual and auditory neural processing. The results indicate that neural codes are better suited to natural inputs and outperform models based on common compression strategies.
ARTIFICIAL INTELLIGENCE REVIEW
(2022)
Article
Biology
Ana Gabriela Jimenez, Evan Nash-Braun
Summary: Heat waves and cold snaps are expected to increase in intensity, duration, interval, and severity in the future. However, current literature on the physiological effects of temperature on organisms does not often consider chronic, variable acclimations, despite the predicted climate change. This study examined how sheepshead minnows acclimated to different temperature regimes and found enzymatic differences in response to low and high cycling temperatures, suggesting potential survival pathways for eurytolerant organisms in variable thermal environments.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Cell Biology
Qiao Zhang, Weiji Weng, Xiaokun Gu, Jinhua Xiang, Yang Yang, Michael X. Zhu, Weidong Gu, Zhenzhou He, Yong Li
Summary: TRPA1 mRNA expression is increased in inflammatory cold hyperalgesia, and hnRNPA1 plays a regulatory role by stabilizing TRPA1 mRNA. Additionally, SUMOylation enhances the ability of hnRNPA1 to regulate TRPA1 expression, contributing to the development of chronic inflammatory cold pain hypersensitivity.
Article
Multidisciplinary Sciences
Elizabeth Trembath-Reichert, Sunita R. Shah Walter, Marc Alec Fontanez Ortiz, Patrick D. Carter, Peter R. Girguis, Julie A. Huber
Summary: The study of microbial biomass production in cool, oxic basement fluids from the western flank of the Mid-Atlantic Ridge indicates a microbial community capable of synthesizing carbon and nitrogen under dynamic conditions. Bicarbonate incorporation rates were highest in isolated fluids, suggesting a potential strategy for supplementing ancient and recalcitrant dissolved organic carbon in the globally distributed subseafloor crustal environment.
Article
Food Science & Technology
Shiyu Chen, Ying Xiao, Wenxiao Tang, Feng Jiang, Jing Zhu, Yiming Zhou, Lin Ye
Summary: This study explored the feasibility of using ultrahigh pressure to shorten the preparation time of cold brew coffee. The results showed that pressure and holding time significantly affected the physicochemical characteristics and flavor characteristics of UHP-assisted cold brew coffee. UHP-assisted cold brew coffee had lower bitterness, higher sweetness, and a softer taste than conventional cold brew coffee.
Review
Biochemistry & Molecular Biology
Dusan Brany, Dana Dvorska, Jan Strnadel, Tatiana Matakova, Erika Halasova, Henrieta Skovierova
Summary: Cold atmospheric plasma shows great potential in modern medicine. It has been used in clinical treatment of skin diseases, chronic wounds, and has effects on tumour cells. Current research focuses on its applications in internal structures and its synergistic effects with pharmaceuticals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Clinical Neurology
Caroline Menard, Tabrez J. Siddiqui, Derya Sargin, Ashley Lawson, Yves De Koninck, Judy Illes
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Marc Lopez-Cano, Joan Font, Ester Aso, Kristoffer Sahlholm, Gisela Cabre, Jesus Giraldo, Yves De Koninck, Jordi Hernando, Amadeu Llebaria, Victor Fernandez-Duenas, Francisco Ciruela
Summary: Photopharmacology offers a promising approach to improve the benefit/risk profiles of opioid-based drugs. This study successfully developed a morphine photo-derivative that can be activated by light, providing effective analgesia without the occurrence of tolerance or associated opioid-related side effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Editorial Material
Clinical Neurology
Melissa L. Perreault, Malcolm King, Chelsea Gabel, Christopher J. Mushquash, Yves De Koninck, Ashley Lawson, Caterina Marra, Caroline Menard, Jennie Z. Young, Judy Illes
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Candler Paige, Isabel Plasencia-Fernandez, Moeno Kume, Melina Papalampropoulou-Tsiridou, Louis-Etienne Lorenzo, Eric T. David, Lucy He, Galo L. Mejia, Christopher Driskill, Francesco Ferrini, Andrew L. Feldhaus, Leon F. Garcia-Martinez, Armen N. Akopian, Yves De Koninck, Gregory Dussor, Theodore J. Price
Summary: The findings suggest that CGRP promotes pain plasticity in female rodents but has a limited impact in males.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Annemarie Dedek, Jian Xu, Louis-Etienne Lorenzo, Antoine G. Godin, Chaya M. Kandegedara, Genevieve Glavina, Jeffrey A. Landrigan, Paul J. Lombroso, Yves De Koninck, Eve C. Tsai, Michael E. Hildebrand
Summary: This study discovered sexual dimorphism in a central neuronal mechanism of chronic pain, providing a foundational step towards a better understanding and treatment of pain in both sexes.
Article
Multidisciplinary Sciences
Shannon Tansley, Ning Gu, Alba Urena Guzman, Weihua Cai, Calvin Wong, Kevin C. Lister, Einer Munoz-Pino, Noosha Yousefpour, R. Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M. Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G. Gkogkas, James W. Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S. Mogil, Arkady Khoutorsky
Summary: After peripheral nerve injury, microglia degrade extracellular matrix structures (PNNs) in the spinal cord dorsal horn, enhancing the output of spinal nociceptive circuits and causing pain hypersensitivity.
Editorial Material
Neurosciences
Edward S. Ruthazer, Jean-Claude Beique, Yves De Koninck
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Neurosciences
Jeremie Guilbert, Antoine Legare, Paul De Koninck, Patrick Desrosiers, Michele Desjardins
Summary: Brain functional connectivity based on blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals is widely used in human neuroimaging. However, the nature of the functional networks revealed by BOLD fMRI can be ambiguous, as recent experiments have shown that resting-state networks can be replicated from purely vascular or physiologically driven BOLD signals.
Article
Cell Biology
Noosha Yousefpour, Samantha Locke, Haley Deamond, Chengyang Wang, Lucas Marques, Manon St-Louis, Johanne Ouellette, Arkady Khoutorsky, Yves De Koninck, Alfredo Ribeiro-da-Silva
Summary: Neuropathic pain is a debilitating condition caused by nerve system damage, and the imbalance of spinal excitation and inhibition is believed to contribute to it. Little is known about the structural basis of this imbalance. Through a preclinical model of neuropathic pain, researchers have found that microglia selectively engulf spinal synapses of central neurons but not peripheral sensory neurons. They also discovered that the removal of inhibitory and excitatory synapses occurs in different temporal patterns, with microglia-mediated inhibitory synapse removal happening before excitatory synapse removal. Additionally, they observed a gradual increase in complement depositions on dorsal horn synapses, which corresponds to the temporal pattern of microglial synapse pruning activity and specific synapse loss.
Review
Clinical Neurology
Marco Battaglia, Cornelius B. Groenewald, Fiona Campbell, Simona Scaini, Yves De Koninck, Jennifer Stinson, Patrick D. Quinn
Summary: This article provides a multidisciplinary assessment of the relationships among mental health, chronic pain, prescribing patterns, and the opioid crisis. It highlights the impact of the crisis on young people and emphasizes the role of prescribing patterns as a modifiable hazard factor. It calls for psychiatrists to take a more active role in leading interdisciplinary conversations and addressing the crisis.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Iason Keramidis, Brendan B. Mcallister, Julien Bourbonnais, Feng Wang, Dominique Isabel, Edris Rezaei, Romain Sansonetti, Phil Degagne, Justin P. Hamel, Mojtaba Nazari, Samsoon Inayat, Jordan C. Dudley, Annie Barbeau, Lionel Froux, Marie-Eve Paquet, Antoine G. Godin, Majid H. Mohajerani, Yves De Koninck
Summary: In mouse models carrying Alzheimer's disease-related mutations, a loss of neuronal membrane KCC2, responsible for maintaining GABA(A)-mediated inhibition, occurs in the hippocampus and prefrontal cortex before symptoms appear. Downregulation of KCC2 is inversely correlated with the age-dependent increase in amyloid-beta 42. Restoring KCC2 function can protect against cognitive decline and memory deficits associated with Alzheimer's disease.
Article
Multidisciplinary Sciences
Beatrice Desy, Patrick Desrosiers, Antoine Allard
Summary: In the past decade, random hyperbolic graphs have successfully explained various properties of real-world networks such as clustering, navigability, and degree distributions. However, current models overlook the choice of latent space dimensionality, which affects the representation of clustered network data. We show that adding just one dimension can generate more realistic and diverse community structures in hyperbolic models.
Article
Multidisciplinary Sciences
Marina Vegue, Vincent Thibeault, Patrick Desrosiers, Antoine Allard, Petros Koumoutsakos
Summary: Dimension reduction is a common strategy to study nonlinear dynamical systems. We propose a two-step method that considers the properties of adjacency matrix for dynamics on weighted directed networks. The reduced system can predict characteristic features of the dynamics for different types of connectivity structures.
Article
Clinical Neurology
Melina Papalampropoulou-Tsiridou, Stephanie Shiers, Feng Wang, Antoine G. Godin, Theodore J. Price, Yves De Koninck
Summary: This study examined the expression pattern of ASIC1, ASIC2, and ASIC3 mRNA in human dorsal root ganglia neurons using an in situ hybridization approach. The results showed broad expression of ASIC1 and ASIC3 subunits in human primary sensory neurons, contrasting with the expression patterns in rodents. These differences should be considered when evaluating the translational potential of ASIC studies in rodents.
BRAIN COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thorn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Seguela, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Summary: The activation of mTORC2 triggered by tissue inflammation causes structural changes in nociceptive free nerve endings, leading to inflammatory pain. Inhibiting the regulatory protein Rictor of mTORC2 can prevent the elongation and branching of nociceptive fibers, reducing inflammatory pain hypersensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)