Article
Physiology
Maria A. Gandini, Ivana A. Souza, Abhishek Kullar, Eder Gambeta, Gerald W. Zamponi
Summary: This study reveals the regulation of Ca(V)3.2 calcium channels by Rack-1 protein in a PKC-dependent manner, which affects calcium ion entry.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Correction
Physiology
Maria A. Gandini, Ivana A. Souza, Abhishek Khullar, Eder Gambeta, Gerald W. Zamponi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Manon Defaye, Nasser S. Abdullah, Mircea Iftinca, Ahmed Hassan, Francina Agosti, Zizhen Zhang, Melissa Cumenal, Gerald W. Zamponi, Christophe Altier
Summary: The research explores the mechanisms of chronic abdominal pain in IBD patients, focusing on the role of neuronal activity in microglial activation and visceral hypersensitivity. It suggests that targeting microglial P2Y12 signaling could potentially alleviate pain in patients in remission.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Richard C. Kevin, Somayeh Mirlohi, Jamie J. Manning, Rochelle Boyd, Elizabeth A. Cairns, Adam Ametovski, Felcia Lai, Jia Lin Luo, William Jorgensen, Ross Ellison, Roy R. Gerona, David E. Hibbs, Iain S. McGregor, Michelle Glass, Mark Connor, Chris Bladen, Gerald W. Zamponi, Samuel D. Banister
Summary: Synthetic cannabinoid receptor agonists (SCRAs) are a class of new psychoactive substances. However, the specific effects of two compounds, MEPIRAPIM and 5F-BEPIRAPIM, are still unclear. These compounds share structural similarities with a class of drugs used for epilepsy and pain treatment. Experimental evaluation showed that these compounds have affinities for both cannabinoid receptors and calcium channels, and may have some agonistic effects. However, testing on mice indicated that the central CB1 receptor activity of MEPIRAPIM and 5F-BEPIRAPIM is minimal.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Anesthesiology
Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Gerald W. Zamponi
Summary: Ca(V)3.2 channels play an important role in trigeminal neuralgia, impacting the occurrence and characteristics of the disease. Mutations in these channels were found in patients, leading to functional changes and exacerbation of pain. By blocking these channels, the severity of pain can be reduced.
Article
Pharmacology & Pharmacy
Paz Duran, Santiago Loya-Lopez, Dongzhi Ran, Cheng Tang, Aida Calderon-Rivera, Kimberly Gomez, Harrison J. Stratton, Sun Huang, Ya-ming Xu, E. M. Kithsiri Wijeratne, Samantha Perez-Miller, Zhiming Shan, Song Cai, Anna T. Gabrielsen, Angie Dorame, Kyleigh A. Masterson, Omar Alsbiei, Cynthia L. Madura, Guoqin Luo, Aubin Moutal, John Streicher, Gerald W. Zamponi, A. A. Leslie Gunatilaka, Rajesh Khanna
Summary: This study identified argentatin C, a compound derived from the Native American medicinal plant Parthenium incanum, which can block the activity of voltage-gated sodium and calcium channels and has potential as a novel treatment for painful conditions. Experimental results demonstrated that argentatin C decreased ion currents and excitability in sensory neurons and relieved postsurgical pain in a mouse model. Therefore, argentatin C may serve as an alternative therapy for chronic pain management.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Erika K. Harding, Ivana A. Souza, Maria A. Gandini, Vinicius M. Gadotti, Md Yousof Ali, Sun Huang, Flavia T. T. Antunes, Tuan Trang, Gerald W. Zamponi
Summary: Cannabinoids are a potential therapy for chronic pain, but their analgesic efficacy is often not reported in clinical trials. This study found that cannabinoids can produce analgesia by inhibiting voltage gate calcium channels, and different cannabinoids target different types of channels through distinct mechanisms. The cannabinoid CBD binds to and occludes the pore of the Ca(v)3.2 channel, alleviating inflammatory and neuropathic pain.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Md Yousof Ali, Vinicius M. Gadotti, Sun Huang, Agustin Garcia-Caballero, Flavia T. T. Antunes, Hyun Ah Jung, Jae Sue Choi, Gerald W. Zamponi
Summary: Cav3.2 channels are important in pain transmission, and ICA-II can inhibit these channels and has analgesic effects in mice.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Md Yousof Ali, Se Eun Park, Su Hui Seong, Gerald W. Zamponi, Hyun Ah Jung, Jae Sue Choi
Summary: This study found that ursonic acid (UNA) and ursolic acid (ULA), two main compounds in Artemisia montana, have inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) and alpha-glucosidase. UNA also increases glucose uptake and decreases PTP1B expression by activating the IRS-1/PI3K/Akt/GSK-3 signaling pathway, showing potential for the treatment of diabetes and its complications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Physiology
Abdulaziz M. M. Alaklabi, Eder Gambeta, Gerald W. W. Zamponi
Summary: Trigeminal neuralgia is a rare and debilitating disorder that leads to severe pain attacks and poor quality of life. A recent study discovered a new missense mutation in the CACNA1G gene, which encodes the Ca(V)3.1 calcium channel, suggesting its important role in trigeminal pain.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Neurosciences
Vinicius de Maria Gadotti, Flavia Tasmin Techera Antunes, Gerald W. Zamponi
Summary: Spinally delivered ?(9)-THC produces analgesic effects by acting on T-type calcium channels rather than activating spinal cannabinoid receptors.
Article
Neurosciences
Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard, Norbert Weiss
Summary: T-type calcium channelopathies are a group of human disorders caused or exacerbated by mutations in genes encoding T-type calcium channels. A new mutation in the CACNA1H gene encoding the Ca(v)3.2 T-type calcium channel was found in a patient with epilepsy and hearing loss, the first CACNA1H mutation associated with a sensorineural hearing condition. This mutation results in minor gating alterations and enhanced sensitivity to external pH change in the channel.
Article
Neurosciences
Heloisa Alonso-Matielo, Zizhen Zhang, Eder Gambeta, Junting Huang, Lina Chen, Gabriel Oliveira de Melo, Camila Squarzoni Dale, Gerald W. Zamponi
Summary: This study found inhibitory neurons projecting from the posterior insula to the anterior cingulate cortex, and stimulation of these projections did not affect mechanical nociception but induced affective responses.
Article
Neurosciences
Daniel F. Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R. Reed, Adair R. S. Santos, Vinicius M. Gadotti, Gerald W. Zamponi
Summary: The present study aimed to investigate the role of Cav3.2 T-type channels in mediating the antihyperalgesic effects of joint manipulation (JM) therapy. Using a chronic constriction injury model in mice, we demonstrated that JM produced long-lasting mechanical antihyperalgesia, which was abolished in Cav3.2 null mice. Additionally, we found that JM displayed a similar analgesic profile to the fatty acid amide hydrolase inhibitor URB597, suggesting a possible shared mechanism of action involving endocannabinoids. Overall, our findings contribute to the understanding of the analgesic mechanisms of JM.
Review
Physiology
Norbert Weiss, Gerald W. Zamponi
Summary: T-type calcium channels play crucial roles in both neuronal and non-neuronal systems, and their functions depend on the interaction with other proteins. This review provides a comprehensive exploration of the current understanding of T-type channel interactors and highlights their potential for drug-based therapeutic interventions.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
