Article
Immunology
Tianwen Yin, Peiliang Wang, Jinming Yu, Feifei Teng
Summary: Treatment-related lymphopenia (TRL) is an independent predictor of poor outcomes in patients with esophageal squamous cell carcinoma (ESCC) receiving anti-PD-1 therapy. Radiotherapy (RT) is a key factor affecting TRL. A shorter time interval of <33.5 days between RT and anti-PD-1 therapy can lead to a poor prognosis by increasing the occurrence of TRL.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Tiago F. Outeiro, Peter Heutink, Erwan Bezard, Angela M. Cenci
Summary: Parkinson's disease is primarily characterized by movement disorders associated with the loss of dopaminergic neurons. However, it is now understood as a complex condition with multiple nonmotor features, involving various protein inclusions. Familial forms of PD have provided insights into the molecular pathways leading to neurodegeneration, adding complexity to the issue. Models using patient-derived cells and animal models, combined with current technological tools, are proposed to expand understanding and identify therapeutic strategies for PD.
MOVEMENT DISORDERS
(2021)
Article
Microbiology
Michelle Coleman, Blair Armistead, Austyn Orvis, Phoenicia Quach, Alyssa Brokaw, Claire Gendrin, Kavita Sharma, Jason Ogle, Sean Merillat, Matthew Dacanay, Tsung-Yen Wu, Jeff Munson, Audrey Baldessari, Jay Vornhagen, Anna Furuta, Shayla Nguyen, Kristina M. Adams Waldorf, Lakshmi Rajagopal
Summary: Invasive bacterial infections during pregnancy, such as Group B streptococci (GBS), can lead to preterm birth, stillbirth, and fetal injury. Using a nonhuman primate model, researchers found that GBS expressing hyaluronidase can cause microbial invasion into the amniotic cavity and preterm labor, shedding light on virulence factors and potential therapeutic strategies. Understanding how bacteria evade host defenses during pregnancy is crucial for developing preventive therapies against adverse outcomes.
Article
Biology
Ziqi Yu, Xiaoyang Han, Wenjing Xu, Jie Zhang, Carsten Marr, Dinggang Shen, Tingying Peng, Xiao-Yong Zhang, Jianfeng Feng
Summary: This study proposes a domain-adaptive and semi-supervised deep neural network called Brain Extraction Net (BEN) for extracting brain tissues across species, MRI modalities, and MR scanners. Compared to conventional toolboxes, BEN demonstrates superior robustness, accuracy, and generalizability.
Article
Medicine, Research & Experimental
Young-Seo Yoon, Han-Jun Hwang, Jae-Min Kim, Kyung-Sook Chung, Seo-Yun Jang, So-Won Heo, Su-Yeon Lee, Soo-Yeon Kim, Hyeon-A. Song, Seung-Jae Hong, Hyo-Jin An, Sang-Wook Park, Jhong-Jae Im, Dong-Ho Oh, Ah-Ram Lee, Kyung-Tae Lee
Summary: The aim of this study was to evaluate the synergic anti-nociceptive and anti-inflammatory effects of DW-1021, an ionic complex of pelubiprofen and tramadol, compared to the administration of pelubiprofen or tramadol alone. The results showed that DW-1021 exhibited strong synergistic antinociceptive efficacy in nociceptive and inflammation-induced nociceptive models. It had a better pain-relieving effect than pelubiprofen but not as much as tramadol, and a stronger anti-inflammatory effect than tramadol but less than pelubiprofen.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Surgery
Suk Kyun Hong, Dongkyu Han, Sun-Kyung Lee, Jiyeon Kim, Eung-Soo Hwang, Haeryoung Kim, Jae-Il Lee, Kwangpyo Hong, Eui Soo Han, Jae-Hyung Cho, Jeong-Moo Lee, YoungRok Choi, Kwang-Woong Lee, Nam-Joon Yi, Jaeseok Yang, Kyung-Suk Suh
Summary: The study showed that using MD-3 as an alternative to traditional immunosuppressants significantly prolonged liver allograft survival in transplanted monkeys, while also effectively suppressing inflammatory cell infiltration and T cell responses.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Simon Eschweiler, James Clarke, Ciro Ramirez-Suastegui, Bharat Panwar, Ariel Madrigal, Serena J. Chee, Ioannis Karydis, Edwin Woo, Aiman Alzetani, Somaia Elsheikh, C. J. Hanley, G. J. Thomas, Peter S. Friedmann, Tilman Sanchez-Elsner, Ferhat Ay, Christian H. Ottensmeier, Pandurangan Vijayanand
Summary: Studies have shown the importance of T-FR cells within tumor tissues in enhancing the efficacy of anti-PD-1 therapy. Depleting or blocking T-FR cells can improve the effectiveness of anti-PD-1 treatment and contribute to better survival outcomes in melanoma patients.
Article
Medicine, Research & Experimental
Yumei Gao, Simeng Hu, Ruoyan Li, Shanzhao Jin, Fengjie Liu, Xiangjun Liu, Yingyi Li, Yicen Yan, Weiping Liu, Jifang Gong, Shuxia Yang, Ping Tu, Lin Shen, Fan Bai, Yang Wang
Summary: This study demonstrated that PD-1 acts as a tumor suppressor for malignant T cells with oncogenic TCR activation, based on the analysis of a patient with advanced cutaneous T cell lymphoma who experienced hyperprogression upon anti-PD-1 treatment. PD-1 blockade led to the activation and proliferation of CD4+ malignant T cells, which exhibited functional PD-1 expression and an exhausted status. Somatic amplification of PRKCQ in the malignant T cells resulted in an oncogenic activation of the TCR signaling pathway.
Review
Oncology
Y. Jansen, A. A. M. van der Veldt, G. Awada, B. Neyns
Summary: Emerging data suggest that immune checkpoint blockade (ICB) therapy can be safely stopped in patients with metastatic melanoma, with an acceptable risk of disease progression. Disease control can be maintained after discontinuation, reducing the risk of adverse events and financial burden. The depth of response is a predictor of prolonged response, and 18F-FDG-PET/CT can be useful for partial responders.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shaul Schreiber, Lee Keidan, Chaim G. G. Pick
Summary: About 30% of major depression disorder patients fail to achieve remission, hence being diagnosed with treatment-resistant major depression (TRD). Opium had been used effectively to treat depression for centuries, but its use was discounted due to addiction and other hazards. In a series of previous studies, we evaluated the effects of eight antidepressant medications and their interaction with the opioid system. Controlled clinical studies are needed to establish the efficacy of opiate antidepressants augmentation for treatment-resistant depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jayane Lais Dias Quintao, Amanda Cristina Reis Gonzaga, Giovane Galdino, Thiago Roberto Lima Romero, JosianeFernandes Silva, VirginiaSoares Lemos, Gabriel Henrique Campolina-Silva, Cleida Aparecida de Oliveira, GermanAnarturo Bohorquez Mahecha, IgorDimitri Gama Duarte
Summary: Tissue injury leads to the release of inflammatory mediators and nociceptive substances, contributing to hyperalgesia. The study investigated the involvement of inflammatory mediators in the modulation of inflammatory pain by the opioid system, finding that TNF-alpha, CXCL-1, and IL-beta cause hyperalgesia and the release of endogenous opioid peptides for pain control.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Benjamin C. Creelan, Chao Wang, Jamie K. Teer, Eric M. Toloza, Jiqiang Yao, Sungjune Kim, Ana M. Landin, John E. Mullinax, James J. Saller, Andreas N. Saltos, David R. Noyes, Leighann B. Montoya, Wesley Curry, Shari A. Pilon-Thomas, Alberto A. Chiappori, Tawee Tanvetyanon, Frederic J. Kaye, Zachary J. Thompson, Sean J. Yoder, Bin Fang, John M. Koomen, Amod A. Sarnaik, Dung-Tsa Chen, Jose R. Conejo-Garcia, Eric B. Haura, Scott J. Antonia
Summary: Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) in combination with nivolumab showed potential safety and clinical activity in patients with advanced non-small cell lung cancer, indicating a promising new treatment strategy for metastatic lung cancer.
Article
Neurosciences
Yuling Yang, Zhiyun Chen, Jing Zhou, Shize Jiang, Guoxiang Wang, Li Wan, Jiangning Yu, Min Jiang, Yulong Wang, Jie Hu, Xu Liu, Yun Wang
Summary: Neuronal PD-1 plays an important role in epilepsy, and anti-PD-1 treatment protects against seizures by suppressing sodium channel function, identifying anti-PD-1 treatment as a novel therapeutic strategy for epilepsy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Haixia Long, Qingzhu Jia, Liuyang Wang, Wenfeng Fang, Zhongyu Wang, Tao Jiang, Fei Zhou, Zheng Jin, Jiani Huang, Li Zhou, Chunyan Hu, Xinxin Wang, Jin Zhang, Yujie Ba, Yujie Gong, Xianghua Zeng, Dong Zeng, Xingxing Su, Peter B. Alexander, Li Wang, Limei Wang, Yisong Y. Wan, Xiao-Fan Wang, Li Zhang, Qi-Jing Li, Bo Zhu
Summary: This study reveals a mechanism by which tumors exploit anemia-triggered erythropoiesis for myeloid transdifferentiation and immunosuppression.
Article
Chemistry, Multidisciplinary
Mengshi Jiang, Bing Qin, Lihua Luo, Xiang Li, Yingying Shi, Junlei Zhang, Zhenyu Luo, Chunqi Zhu, Guannan Guan, Yongzhong Du, Jian You
Summary: The study compared three methods of alleviating tumor hypoxia in terms of biosafety, efficacy and clinical applicability, with Hb@lipo standing out as a promising oxygen carrier. The combination therapy with PD-1 antibody showed a distinct synergistic suppression effect on tumors with more M1 macrophages.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Energy & Fuels
Sibo Zhao, Zihua Wang, Chun Chang, Pan Li, Guizhuan Xu, Shusheng Pang
Summary: A two-stage alcoholysis method was developed for converting furfural residue into levulinic acid and methyl levulinate, achieving a maximum total yield of 25.64%. Pretreatment of the residue with HCOOH/H2O2 increased the cellulose content and resulted in a maximum total yield of 44.96%, which was 16.09% higher than isothermal alcoholysis.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Business, Finance
Zhiwen Zhang, Zilong Wang, Shan Liang
Summary: The study analyzed the misallocation of resources in innovation in China's high-tech industry sector and constructed a model for measuring the misallocation at the department level. The empirical findings showed that there is a misallocation of innovation resources in the high-tech industry sector, with government intervention and an increase in the share of SOEs in the industry exacerbating the misallocation.
ASIA-PACIFIC JOURNAL OF ACCOUNTING & ECONOMICS
(2023)
Article
Engineering, Manufacturing
Zilong Wang, JiaCheng Zhou, Fang Liu, Yuqin Wu, Nu Yan
Summary: The purpose of this study is to investigate the microstructure and properties of Sn-3.5Ag and Sn-3.5Ag-0.5Sb lead-free solder alloys with and without a rotating magnetic field (RMF). The results showed that the application of RMF had a significant effect on the microstructure and mechanical properties of the solder alloys. The thermal characteristics of the alloys were also improved under the RMF.
SOLDERING & SURFACE MOUNT TECHNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Zi-Long Wang, Jia-Rui Zheng, Rui-Feng Yang, Lin-Xiang Huang, Hong-Song Chen, Bo Feng
Summary: In the era of antiviral therapy, the goal of treating chronic hepatitis B has shifted to achieving serological clearance of HBs surface antigen (HBsAg), which signifies the elimination or inactivity of the HBV genome. HBsAg loss improves immune function recovery and can potentially lead to complete cure of CHB. High-sensitivity HBsAg detection may serve as a surrogate for complete cure.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lixuan Li, Pupu Li, Jing Guo, Yifei Wu, Qian Zeng, Nan Li, Xiaoting Huang, Yongshen He, Wen Ai, Wuping Sun, Tao Liu, Donglin Xiong, Lizu Xiao, Yanyan Sun, Qiming Zhou, Haixia Kuang, Zilong Wang, Changyu Jiang
Summary: This study found that the expression of oxytocin receptors (OXTR) is upregulated in chemotherapy-induced neuropathic pain (CINP), and activation of OXTR can alleviate CINP symptoms by inhibiting neural excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Geosciences, Multidisciplinary
Ziwei Wang, Laiming Huang, Ming 'an Shao
Summary: Understanding the distribution and factors influencing soil organic carbon (SOC) is crucial for assessing soil carbon sink potential and ecosystem quality. However, studying SOC content and stock under different land use types in the alpine region of Qinghai-Tibetan Plateau is challenging. This study investigated the distribution and controls of SOC in the Tibet alpine region, finding that soil properties and environmental conditions play a role in SOC spatial distribution under various land use patterns.
Review
Engineering, Environmental
Zixin Wang, Fan Rong, Zhao Li, Wei Li, Kuljeet Kaur, Yin Wang
Summary: This review presents the application of gas therapy in wound treatment, including the design and fabrication of GSM-releasing nanoplatforms, different synthetic strategies, and the study of single gas therapy and combined therapy. In addition, the characteristics of nanoplatforms capable of releasing multiple gas molecules are discussed. Finally, the future development and challenges of this treatment method for wound closure are discussed.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Xiang Li, Shifeng Yin, Lei Cai, Zilong Wang, Chengyong Zeng, HaoJie Jiang, Jie Cheng, Wei Lu
Summary: Developing lightweight and high absorption capacity electromagnetic wave absorbing materials is an effective solution to electromagnetic wave pollution. This study successfully synthesized MXene/NCS hybrid materials with good absorption performance, and provided new ideas for designing and synthesizing lightweight and efficient electromagnetic wave absorbing materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Anesthesiology
Kenta Furutani, Ouyang Chen, Aidan McGinnis, Yuqing Wang, Charles N. Serhan, Trond Vidar Hansen, Ru-Rong Ji
Summary: The article demonstrates that 3-oxa-PD1 effectively reduces both acute and chronic itch in mouse models by regulating synaptic transmission and astroglial LCN2 production. Stable SPM analogs like 3-oxa-PD1 could be useful in treating pruritus associated with different skin injuries.
Article
Chemistry, Multidisciplinary
Xiaohui Guo, Weiqiang Hong, Yunong Zhao, Tong Zhu, Long Liu, Hongjin Li, Ziwei Wang, Dandan Wang, Zhihong Mai, Tianxu Zhang, Jinyang Yang, Fengzhe Zhang, Yun Xia, Qi Hong, Yaohua Xu, Feng Yan, Ming Wang, Guozhong Xing
Summary: This study proposes a high-performance dual-mode stretchable strain sensor (DMSSS) based on biomimetic scorpion foot slit microstructures and multi-walled carbon nanotubes/graphene/silicone rubber/Fe3O4 nanocomposites. The sensor exhibits a large strain detection range, ultra-low detection limit of strain, and superior durability. It can accurately sense strain and magnetic stimuli, and can be applied in sign language pose recognition, non-contact sensing, human-computer interaction, and electronic skin.
Article
Chemistry, Multidisciplinary
Mingrui Liao, Haoning Gong, Xuebo Quan, Ziwei Wang, Xuzhi Hu, Zheng Chen, Zongyi Li, Huayang Liu, Lin Zhang, Andrew J. J. McBain, Thomas A. A. Waigh, Jian Zhou, Jian Ren Lu
Summary: This study characterizes the interaction of short cationic antimicrobial peptides (AMPs) with bacterial outer and inner membranes and their impact on antimicrobial efficacy. The results show that different AMPs form distinct intramembrane nanoaggregates, with smaller sizes and greater extent of insertion correlating with better antimicrobial efficacy and faster killing.
Article
Neurosciences
Fabiana C. Dias, Zilong Wang, Garrett Scapellato, Yong Chen
Summary: Co-application of QX-314, a positively charged, membrane-impermeable lidocaine derivative, with the TRPV4 selective agonist GSK101, can suppress the excitability of trigeminal ganglion (TG) neurons. In mouse models of temporomandibular joint inflammation and masseter muscle injury, co-administration of QX-314 and GSK101 into the TG significantly attenuated pain. These findings suggest that TRPV4-expressing TG neurons may represent a potential therapeutic target for temporomandibular disorders (TMD) pain.
Article
Medicine, Research & Experimental
Ouyang Chen, Qianru He, Qingjian Han, Kenta Furutani, Yun Gu, Madelynne Olexa, Ru-Rong Ji
Summary: Our understanding of neuropathic itch is limited due to a lack of relevant animal models. In this study, we established a mouse model of chronic itch by inoculating cutaneous T cell lymphoma (CTCL) in mice. The model exhibited lymphoma growth, immune cell accumulation, and persistent pruritus. We observed time-dependent changes in nerve innervations and identified different mechanisms underlying acute, chronic, and neuropathic itch.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Organic
Jianlin Zou, Hongye Li, Zilong Wang, Min Ye
Summary: This passage describes the identification of two efficient and selective glycosyltransferases from Sophora japonica L. One enzyme, Sj3GT, can regio-selectively catalyze 3O-glucosylation of quercetin to produce isoquercitrin, while the other enzyme, Sj6RhaT, further catalyzes its 6-O-rhamnosylation to generate rutin. It is noteworthy that Sj6RhaT exhibits high sugar donor selectivity towards UDP-rhamnose.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Engineering, Environmental
Xinkai Xie, Yuxiao Fang, Cheng Lu, Yi Tao, Li Yin, Yibo Zhang, Zixin Wang, Shiyan Wang, Jianwen Zhao, Xin Tu, Xuhui Sun, Eng Gee Lim, Chun Zhao, Yina Liu, Zhen Wen
Summary: This study investigates the contact electrification mechanism of triboelectric nanogenerators (TENGs) and presents a solution to enhance the stability of the surface potential by embedding a high-permittivity electron blocking layer (HPEBL) into the TENG. The performance of the HPEBL-based TENG is characterized and the dielectric behavior of LaZrO thin films is analyzed. The results demonstrate the potential applications of HPEBL in improving the output performance of TENGs.
CHEMICAL ENGINEERING JOURNAL
(2023)