A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

(2019) Frances Humby et al.   ANNALS OF THE RHEUMATIC DISEASES

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Global, regional and national burden of rheumatoid arthritis 1990–2017: a systematic analysis of the Global Burden of Disease study 2017

(2019) Saeid Safiri et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

(2019) Myles J. Lewis et al.   Cell Reports

Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)

(2019) Gloria Lliso-Ribera et al.   ANNALS OF THE RHEUMATIC DISEASES

Early non-response to certolizumab pegol in rheumatoid arthritis predicts treatment failure at one year. Data from a randomised phase III clinical trial

(2018) Francis Berenbaum et al.   JOINT BONE SPINE

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data

(2018) Dana E. Orange et al.   Arthritis & Rheumatology

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

(2015) Josef S. Smolen et al.   Nature Reviews Rheumatology

Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability

(2015) Bart V. J. Cuppen et al.   RHEUMATOLOGY

Use of Ultrasound-Guided Small Joint Biopsy to Evaluate the Histopathologic Response to Rheumatoid Arthritis Therapy: Recommendations for Application to Clinical Trials

(2015) Frances Humby et al.   Arthritis & Rheumatology

From Synovial Tissue to Peripheral Blood: Myeloid Related Protein 8/14 Is a Sensitive Biomarker for Effective Treatment in Early Drug Development in Patients with Rheumatoid Arthritis

(2014) Ivy Y. Choi et al.   PLoS One

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

(2014) Glynn Dennis et al.   ARTHRITIS RESEARCH & THERAPY

Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

New learnings on the pathophysiology of RA from synovial biopsies

(2013) Costantino Pitzalis et al.   CURRENT OPINION IN RHEUMATOLOGY

Timing and Magnitude of Initial Change in Disease Activity Score 28 Predicts the Likelihood of Achieving Low Disease Activity at 1 Year in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol: A Post-hoc Analysis of the RAPID 1 Trial

(2012) DÉSIRÉE VAN DER HEIJDE et al.   JOURNAL OF RHEUMATOLOGY

Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis

(2010) C. Salliot et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood

(2010) Lisa G. M. van Baarsen et al.   ARTHRITIS AND RHEUMATISM

The Gene Expression Profile in the Synovium as a Predictor of the Clinical Response to Infliximab Treatment in Rheumatoid Arthritis

(2010) Johan Lindberg et al.   PLoS One

The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study

(2009) Ruth Klaasen et al.   ARTHRITIS AND RHEUMATISM

Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis

(2009) Valérie Badot et al.   ARTHRITIS RESEARCH & THERAPY

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor   therapy in rheumatoid arthritis

(2008) J D Canete et al.   ANNALS OF THE RHEUMATIC DISEASES

Power doppler ultrasonographic monitoring of response to anti-tumor necrosis factor therapy in patients with rheumatoid arthritis

(2008) Esperanza Naredo et al.   ARTHRITIS AND RHEUMATISM

The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab)

(2008) M. H. Buch et al.   RHEUMATOLOGY