PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets

Citrullination Is Not a Major Determinant in the Recognition of Peptidylarginine Deiminase 2 and 4 by Autoantibodies in Rheumatoid Arthritis

(2020) Erika Darrah et al.   Arthritis & Rheumatology

Smoking, HLA-genes and serology in rheumatoid arthritis; complex relationships investigated in the Swedish EIRA case-control study

(2019) Anna Karin Hedström et al.   Arthritis & Rheumatology

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts

(2019) Akilan Krishnamurthy et al.   JOURNAL OF IMMUNOLOGY

Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans

(2019) Aisha M. Mergaert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients

(2019) Mandvi Sharma et al.   Journal of Proteomics

Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis

(2019) MK Jonsson et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

(2019) Eduardo Gómez-Bañuelos et al.   Journal of Clinical Medicine

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint

(2018) Jennifer Pieper et al.   JOURNAL OF AUTOIMMUNITY

Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis

(2018) Kari Guderud et al.   JOURNAL OF RHEUMATOLOGY

Mining the Human Tissue Proteome for Protein Citrullination

(2018) Chien-Yun Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis

(2018) M. Kristen Demoruelle et al.   Arthritis & Rheumatology

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

(2018) V. Michael Holers et al.   Nature Reviews Rheumatology

Antibodies targeting protein-arginine deiminase 4 (PAD4) demonstrate diagnostic value in rheumatoid arthritis

(2018) Laura Martinez-Prat et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of baseline peptidylarginine deiminase 4 autoantibodies with favorable response to treatment escalation in rheumatoid arthritis

(2018) Erika Darrah et al.   Arthritis & Rheumatology

Citrullinated Aggrecan Epitopes as Targets of Auto-reactive CD4+ T cells in Patients with Rheumatoid Arthritis

(2018) Cliff Rims et al.   Arthritis & Rheumatology

Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis

(2018) Erika Darrah et al.   Frontiers in Immunology

Sputum Anticitrullinated Protein Antibodies in Patients With Long-standing Rheumatoid Arthritis

(2017) Ari Polachek et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation

(2017) Mandar Bawadekar et al.   JOURNAL OF AUTOIMMUNITY

Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin

(2017) Cecilia Engdahl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The case for periodontitis in the pathogenesis of rheumatoid arthritis

(2017) Jan Potempa et al.   Nature Reviews Rheumatology

Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types

(2017) Fanny Arnoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4

(2017) Nathalie E. Blachère et al.   Arthritis & Rheumatology

Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients

(2017) M. Kristen Demoruelle et al.   Arthritis & Rheumatology

Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils

(2017) Yebin Zhou et al.   Frontiers in Immunology

Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

(2016) Akari Suzuki et al.   BMC MUSCULOSKELETAL DISORDERS

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

(2016) Erika Darrah et al.   JOURNAL OF PROTEOME RESEARCH

Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers

(2016) Dres Damgaard et al.   RHEUMATOLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

(2016) M. F. Konig et al.   Science Translational Medicine

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses

(2016) Joanna Kawalkowska et al.   Scientific Reports

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism

(2015) Gustaf Wigerblad et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features

(2015) Z. Reyes-Castillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases

(2015) Naoto Umeda et al.   CLINICAL RHEUMATOLOGY

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

(2015) Erin Witalison et al.   CURRENT DRUG TARGETS

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Genomic modulators of gene expression in human neutrophils

(2015) Vivek Naranbhai et al.   Nature Communications

Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model

(2015) Yu Seri et al.   Scientific Reports

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

(2015) Julia Spengler et al.   Arthritis & Rheumatology

The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities

(2014) Constance Assohou-Luty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Citrullination regulates pluripotency and histone H1 binding to chromatin

(2014) Maria A. Christophorou et al.   NATURE

Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

(2014) Dres Damgaard et al.   ARTHRITIS RESEARCH & THERAPY

Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor α-Induced Inflammatory Arthritis

(2014) Miriam A. Shelef et al.   Arthritis & Rheumatology

Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

(2013) Benjamin A Fisher et al.   ANNALS OF THE RHEUMATIC DISEASES

Prevalence of Anti-Peptidylarginine Deiminase Type 4 Antibodies in Rheumatoid Arthritis and Unaffected First-degree Relatives in Indigenous North American Populations

(2013) E. D. Ferucci et al.   JOURNAL OF RHEUMATOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Erosive Rheumatoid Arthritis Is Associated with Antibodies That Activate PAD4 by Increasing Calcium Sensitivity

(2013) E. Darrah et al.   Science Translational Medicine

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

(2013) V. Romero et al.   Science Translational Medicine

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

The influence of ACPA status and characteristics on the course of RA

(2012) Annemiek Willemze et al.   Nature Reviews Rheumatology

Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis

(2012) William P. Arend et al.   Nature Reviews Rheumatology

Correction: Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms in peptidylarginine deiminase (PADI) associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis

(2012) Chun Lai Too et al.   ARTHRITIS RESEARCH & THERAPY

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

(2011) Erika Darrah et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide association study of rheumatoid arthritis in Koreans: Population-specific loci as well as overlap with European susceptibility loci

(2011) Jan Freudenberg et al.   ARTHRITIS AND RHEUMATISM

Autodeimination of Protein Arginine Deiminase 4 Alters Protein–Protein Interactions but Not Activity

(2011) Jessica L. Slack et al.   BIOCHEMISTRY

Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders

(2011) Ludvig M Sollid et al.   CURRENT OPINION IN IMMUNOLOGY

The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population

(2011) Chikashi Terao et al.   HUMAN MOLECULAR GENETICS

Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53

(2011) Qin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2

(2011) Qin Guo et al.   Molecular BioSystems

Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate

(2011) Sylvie Pollmann et al.   RHEUMATOLOGY INTERNATIONAL

Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis

(2010) Jason R. Kolfenbach et al.   ARTHRITIS AND RHEUMATISM

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

(2010) Felipe Andrade et al.   ARTHRITIS AND RHEUMATISM

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis

(2010) Natalia Wegner et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Granzyme B cleavage of autoantigens in autoimmunity

(2010) E Darrah et al.   CELL DEATH AND DIFFERENTIATION

Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases

(2010) Marie-Claire Méchin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The rheumatoid arthritis HLA–DRB1 shared epitope

(2010) Joseph Holoshitz   CURRENT OPINION IN RHEUMATOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease

(2009) Byungki Jang et al.   ACTA NEUROPATHOLOGICA

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Rheumatoid arthritis–specific autoantibodies to peptidyl arginine deiminase type 4 inhibit citrullination of fibrinogen

(2009) Isabelle Auger et al.   ARTHRITIS AND RHEUMATISM

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

The expression of PADI4 in synovium of rheumatoid arthritis

(2009) Xiaotian Chang et al.   RHEUMATOLOGY INTERNATIONAL

Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-  blocking agents

(2008) E H Halvorsen et al.   ANNALS OF THE RHEUMATIC DISEASES

Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles

(2008) O Snir et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis

(2008) Michelle L. Harris et al.   ARTHRITIS AND RHEUMATISM

Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis

(2008) Andrew Kinloch et al.   ARTHRITIS AND RHEUMATISM

Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities

(2008) Dorothy D Wood et al.   LABORATORY INVESTIGATION

Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4

(2008) P. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

A functional haplotype and expression of thePADI4gene associated with increased rheumatoid arthritis susceptibility in Chinese

(2008) L. Y. Fan et al.   TISSUE ANTIGENS