APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
出版年份 2022 全文链接
标题
APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
作者
关键词
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出版物
MOLECULAR PSYCHIATRY
Volume 27, Issue 4, Pages 1970-1989
出版商
Springer Science and Business Media LLC
发表日期
2022-02-23
DOI
10.1038/s41380-022-01454-5
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
- (2021) Valentina N. Lagomarsino et al. NEURON
- Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation
- (2020) Jan Tomasz Czermiński et al. DEVELOPMENTAL CELL
- Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics
- (2020) Blandine Ponroy Bally et al. HUMAN MOLECULAR GENETICS
- A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients
- (2020) Dorte B. Bekker-Jensen et al. MOLECULAR & CELLULAR PROTEOMICS
- Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
- (2020) Erik C. B. Johnson et al. NATURE MEDICINE
- Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome
- (2020) Alexandra Botté et al. Acta Neuropathologica Communications
- Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
- (2020) Lingyan Ping et al. Scientific Data
- Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
- (2020) Lenora Higginbotham et al. Science Advances
- Alzheimer‐like pathology in trisomy 21 cerebral organoids amenable to pharmacological inhibition reveals BACE2 as a gene‐dose‐sensitive AD‐suppressor in human brain
- (2020) Ivan Alic et al. Alzheimers & Dementia
- Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
- (2020) Yusuke Fukuda et al. JOURNAL OF CELL BIOLOGY
- OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome
- (2019) Ranjie Xu et al. Cell Stem Cell
- Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions
- (2019) Maria Sobol et al. MOLECULAR NEUROBIOLOGY
- A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
- (2019) Evgeny Shlevkov et al. Cell Reports
- Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
- (2019) Yi-Chen Hsieh et al. Cell Reports
- Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP
- (2018) Frances K Wiseman et al. BRAIN
- Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
- (2018) Daniel J. Colacurcio et al. FREE RADICAL BIOLOGY AND MEDICINE
- Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21
- (2018) Patrick K. Gonzales et al. PLoS One
- Near-atomic model of microtubule-tau interactions
- (2018) Elizabeth H. Kellogg et al. SCIENCE
- Competition between microtubule-associated proteins directs motor transport
- (2018) Brigette Y. Monroy et al. Nature Communications
- Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons
- (2018) Hai-Qin Huo et al. Stem Cell Reports
- The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons
- (2018) Dmitry A. Ovchinnikov et al. Stem Cell Reports
- Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
- (2018) Lingyan Ping et al. Scientific Data
- DYRK1A and cognition: A lifelong relationship
- (2018) Maria L. Arbones et al. PHARMACOLOGY & THERAPEUTICS
- Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease
- (2018) Christy O.Y. Hung et al. Cell Reports
- Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro
- (2017) Bruno H. S. Araujo et al. MOLECULAR NEUROBIOLOGY
- Differential analysis of RNA-seq incorporating quantification uncertainty
- (2017) Harold Pimentel et al. NATURE METHODS
- BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon
- (2017) Ginny G. Farías et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams
- (2017) Abdullah R. Chaudhary et al. TRAFFIC
- Neurofilaments and Neurofilament Proteins in Health and Disease
- (2017) Aidong Yuan et al. Cold Spring Harbor Perspectives in Biology
- Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
- (2017) Christina R. Muratore et al. Stem Cell Reports
- A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
- (2017) Nicholas T. Seyfried et al. Cell Systems
- Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities
- (2016) Tracy L Young-Pearse et al. CURRENT OPINION IN NEUROBIOLOGY
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Near-optimal probabilistic RNA-seq quantification
- (2016) Nicolas L Bray et al. NATURE BIOTECHNOLOGY
- Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination
- (2016) Jose Luis Olmos-Serrano et al. NEURON
- RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer’s disease
- (2015) Helen Wong et al. ACTA NEUROPATHOLOGICA
- Functions of neurofilaments in synapses
- (2015) A Yuan et al. MOLECULAR PSYCHIATRY
- Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo
- (2015) A Yuan et al. MOLECULAR PSYCHIATRY
- Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration
- (2015) Aoife Murray et al. STEM CELLS
- Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease
- (2014) Chadwick M. Hales et al. BRAIN PATHOLOGY
- The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
- (2014) Christina R. Muratore et al. HUMAN MOLECULAR GENETICS
- Domains of genome-wide gene expression dysregulation in Down’s syndrome
- (2014) Audrey Letourneau et al. NATURE
- RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells
- (2014) Heshan Peiris et al. Oxidative Medicine and Cellular Longevity
- RCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal Apoptosis
- (2014) Xiulian Sun et al. PLoS One
- Synaptojanin 1 Mutation in Parkinson’s Disease Brings Further Insight into the Neuropathological Mechanisms
- (2014) Valérie Drouet et al. Biomed Research International
- Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters
- (2013) Beata Machnicka et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21
- (2013) Youssef Hibaoui et al. EMBO Molecular Medicine
- Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model
- (2013) Li Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Translating dosage compensation to trisomy 21
- (2013) Jun Jiang et al. NATURE
- Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
- (2013) Yingsha Zhang et al. NEURON
- TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites
- (2013) Myrrhe van Spronsen et al. NEURON
- U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
- (2013) B. Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deficits in human trisomy 21 iPSCs and neurons
- (2013) J. P. Weick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recent developments of protein kinase inhibitors as potential AD therapeutics
- (2013) Volkmar Tell et al. Frontiers in Cellular Neuroscience
- Modeling neurogenesis impairment in down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells
- (2012) Huai-En Lu et al. EXPERIMENTAL CELL RESEARCH
- Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
- (2012) Jack-Christophe Cossec et al. HUMAN MOLECULAR GENETICS
- Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory
- (2012) Katherine R. Martin et al. HUMAN MOLECULAR GENETICS
- Reduction of Synaptojanin 1 Ameliorates Synaptic and Behavioral Impairments in a Mouse Model of Alzheimer's Disease
- (2012) L. B. J. McIntire et al. JOURNAL OF NEUROSCIENCE
- Role of common and rare APP DNA sequence variants in Alzheimer disease
- (2012) B. V. Hooli et al. NEUROLOGY
- Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology
- (2012) James A. Briggs et al. STEM CELLS
- Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation
- (2011) Xiulian Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A
- (2011) W. Qian et al. NUCLEIC ACIDS RESEARCH
- Link Between DYRK1A Overexpression and Several-Fold Enhancement of Neurofibrillary Degeneration With 3-Repeat Tau Protein in Down Syndrome
- (2010) Jerzy Wegiel et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Cognitive deficits and associated neurological complications in individuals with Down's syndrome
- (2010) Ira T Lott et al. LANCET NEUROLOGY
- Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series
- (2010) Daniel McNaughton et al. NEUROBIOLOGY OF AGING
- Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease
- (2009) K Kasuga et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies
- (2009) J. O. Korbel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
- (2008) Fei Liu et al. FASEB JOURNAL
- Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome
- (2008) Jianhua Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
- (2008) S. V. Voronov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
- (2008) R. Dixit et al. SCIENCE
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