Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival

Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

(2020) Raul Krauss et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

(2020) Junjun Zhao et al.   eLife

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions

(2019) Julia K. Nussbacher et al.   NEURON

Molecular anatomy of the architectural NEAT1 noncoding RNA: The domains, interactors, and biogenesis pathway required to build phase‐separated nuclear paraspeckles

(2019) Tetsuro Hirose et al.   Wiley Interdisciplinary Reviews-RNA

A new crystal structure and small-angle X-ray scattering analysis of the homodimer of human SFPQ

(2019) Thushara Welwelwela Hewage et al.   Acta Crystallographica Section F-Structural Biology Communications

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The travels of mRNAs in neurons: do they know where they are going?

(2019) Sulagna Das et al.   CURRENT OPINION IN NEUROBIOLOGY

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Hot-spot KIF5A mutations cause familial ALS

(2018) David Brenner et al.   BRAIN

Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1)

(2018) T Quyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal mRNA transport and translation at a glance

(2018) Pabitra K. Sahoo et al.   JOURNAL OF CELL SCIENCE

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

(2018) Raphaelle Luisier et al.   Nature Communications

Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin

(2018) Mandira Dutta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

(2018) Stefano Pernigo et al.   eLife

Wide phenotypic spectrum in axonal Charcot–Marie–Tooth neuropathy type 2 patients with KIF5A mutations

(2017) Da Eun Nam et al.   Genes & Genomics

Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development

(2017) Swapna Thomas-Jinu et al.   NEURON

Paclitaxel Reduces Axonal Bclw to Initiate IP 3 R1-Dependent Axon Degeneration

(2017) Sarah E. Pease-Raissi et al.   NEURON

Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport

(2017) Roderick P. Tas et al.   NEURON

Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia

(2017) Scott Jennings et al.   PLoS One

multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data

(2017) William M. Alexander et al.   PROTEOMICS

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

(2017) Natalia Salvadores et al.   Frontiers in Neuroscience

Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites

(2016) J. Lipka et al.   EMBO JOURNAL

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability

(2016) Katharina E Cosker et al.   NATURE NEUROSCIENCE

The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function

(2016) Yosuke Tanaka et al.   NEURON

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

(2015) Lauren A. Barclay et al.   MOLECULAR CELL

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

(2015) Bin Wang et al.   Cell Reports

Vaccinia Virus Protein Complex F12/E2 Interacts with Kinesin Light Chain Isoform 2 to Engage the Kinesin-1 Motor Complex

(2015) David C. J. Carpentier et al.   PLoS Pathogens

Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons

(2014) P. D. Campbell et al.   JOURNAL OF NEUROSCIENCE

Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy

(2014) Y.-T. Liu et al.   NEUROLOGY

Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation

(2013) Sebastian Baumann et al.   EMBO REPORTS

Delineation of the TRAK binding regions of the kinesin-1 motor proteins

(2013) Thomas S. Randall et al.   FEBS LETTERS

Target-Derived Neurotrophins Coordinate Transcription and Transport of Bclw to Prevent Axonal Degeneration

(2013) K. E. Cosker et al.   JOURNAL OF NEUROSCIENCE

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance

(2012) Byung C. Yoon et al.   CELL

Molecular Motor KIF5A Is Essential for GABAA Receptor Transport, and KIF5A Deletion Causes Epilepsy

(2012) Kazuo Nakajima et al.   NEURON

Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms

(2012) Haizhong Zhu et al.   PLoS One

Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model

(2012) Petra Füger et al.   PLoS Genetics

Sensory Neuropathy Attributable to Loss of Bcl-w

(2011) S. L. Courchesne et al.   JOURNAL OF NEUROSCIENCE

The Translocation Selectivity of the Kinesins that Mediate Neuronal Organelle Transport

(2011) Chun-fang Huang et al.   TRAFFIC

Kinesin I Transports Tetramerized Kv3 Channels through the Axon Initial Segment via Direct Binding

(2010) M. Xu et al.   JOURNAL OF NEUROSCIENCE

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

The complete peptide dictionary - A meta-proteomics resource

(2010) Manor Askenazi et al.   PROTEOMICS

Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells

(2009) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

multiplierz: an extensible API based desktop environment for proteomics data analysis

(2009) Jignesh R Parikh et al.   BMC BIOINFORMATICS

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

mzAPI: a new strategy for efficiently sharing mass spectrometry data

(2009) Manor Askenazi et al.   NATURE METHODS

Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity

(2008) Bettina Ebbing et al.   HUMAN MOLECULAR GENETICS