Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

Reducing GABAA  5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome

(2013) C. Martinez-Cue et al.   JOURNAL OF NEUROSCIENCE

Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

(2012) M. Martinez de Lagran et al.   CEREBRAL CORTEX

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors

(2012) Jie Lu et al.   HUMAN MOLECULAR GENETICS

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

(2012) Bozena Mazur-Kolecka et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome

(2012) Y. Shi et al.   Science Translational Medicine

Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases

(2012) Youssef Hibaoui et al.   Frontiers in Physiology

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

(2011) B. Hammerle et al.   DEVELOPMENT

The use of mouse models to understand and improve cognitive deficits in Down syndrome

(2011) I. Das et al.   Disease Models & Mechanisms

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6

(2010) Toshiyuki Yamamoto et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes

(2010) Eva Lilienthal et al.   BMC BIOCHEMISTRY

Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

(2010) Sandra Guidi et al.   BRAIN PATHOLOGY

MNB/DYRK1A as a multiple regulator of neuronal development

(2010) Francisco J. Tejedor et al.   FEBS Journal

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

(2010) Joongkyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

(2010) O. Yabut et al.   JOURNAL OF NEUROSCIENCE

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

Human Embryonic Stem Cells as Models for Aneuploid Chromosomal Syndromes

(2010) Juan-Carlos Biancotti et al.   STEM CELLS

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells

(2009) Anita Bhattacharyya et al.   DEVELOPMENTAL NEUROSCIENCE

Phenazopyridine induces and synchronizes neuronal differentiation of embryonic stem cells

(2009) David M. Suter et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cells

(2009) Youssef Hibaoui et al.   JOURNAL OF PINEAL RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

REST and CoREST Modulate Neuronal Subtype Specification, Maturation and Maintenance

(2009) Joseph J. Abrajano et al.   PLoS One

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Monozygotic twins discordant for trisomy 21 and maternal 21q inheritance: A complex series of events

(2008) Sophie Dahoun et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development

(2008) Ariadna Laguna et al.   DEVELOPMENTAL CELL

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH