The Role of Post-Translational Modifications on the Structure and Function of Tau Protein

Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner

(2022) Francesca Parolini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Lys 280 ➔ Gln mutation mimicking disease‐linked acetylation of Lys 280 in tau extends the structural core of fibrils and modulates their catalytic properties

(2021) Harish Kumar et al.   PROTEIN SCIENCE

Implications of Glycosylation in Alzheimer’s Disease

(2021) Henriette Haukedal et al.   Frontiers in Neuroscience

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

(2021) Carolina Alquezar et al.   Frontiers in Neurology

Isoform-selective decrease of glycogen synthase kinase-3 beta (GSK-3β) reduces synaptic tau phosphorylation, trans-cellular spreading and aggregation

(2021) Ana Claudia Amaral et al.   iScience

Tau Oligomers Neurotoxicity

(2021) Grazyna Niewiadomska et al.   Life-Basel

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

(2021) Peter E. A. Ash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-Induced Structural Reorganization in Tau-Paired Helical Filaments

(2021) Lata Rani et al.   ACS Chemical Neuroscience

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

(2021) Yang Shi et al.   ACTA NEUROPATHOLOGICA

Reducing acetylated tau is neuroprotective in brain injury

(2021) Min-Kyoo Shin et al.   CELL

TBK1 interacts with tau and enhances neurodegeneration in tauopathy

(2021) Measho H. Abreha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

Tau seeds are subject to aberrant modifications resulting in distinct signatures

(2021) Jui-Heng Tseng et al.   Cell Reports

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

(2021) Sang-Gyun Kang et al.   BMC BIOLOGY

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo

(2021) Taro Saito et al.   HUMAN MOLECULAR GENETICS

Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model

(2021) Chengchen Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity

(2021) Bin Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation

(2021) Jitao Wen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease

(2021) Maria Bichmann et al.   Molecular Neurodegeneration

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

(2021) Yuxing Xia et al.   Scientific Reports

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

(2021) François-Xavier Cantrelle et al.   Frontiers in Molecular Neuroscience

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

(2021) Chen Lyu et al.   Frontiers in Molecular Biosciences

Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease

(2021) Trae Carroll et al.   Biology-Basel

Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions

(2020) Yanxian Lin et al.   ACS Chemical Neuroscience

Semisynthetic and Enzyme-Mediated Conjugate Preparations Illuminate the Ubiquitination-Dependent Aggregation of Tau Protein

(2020) Francesca Munari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Effect of Phosphorylation and O-GlcNAcylation on Proline-Rich Domains of Tau

(2020) Lata Rani et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Differences Between Human and Murine Tau at the N-terminal End

(2020) Félix Hernández et al.   Frontiers in Aging Neuroscience

Zinc promotes liquid–liquid phase separation of tau protein

(2020) Virender Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies

(2020) Francesca Munari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Truncation of tau selectively facilitates its pathological activities

(2020) Jianlan Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death

(2020) Mengyu Liu et al.   MOLECULAR NEUROBIOLOGY

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

(2020) Nicholas M. Kanaan et al.   Nature Communications

Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates

(2020) Adriana Savastano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration

(2020) Yelena Losev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The structure and phase of tau: from monomer to amyloid filament

(2020) Yifan Zeng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The proline-rich domain promotes Tau liquid–liquid phase separation in cells

(2020) Xuemei Zhang et al.   JOURNAL OF CELL BIOLOGY

Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

(2020) Joanna Abi Habib et al.   Scientific Reports

Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster

(2020) Iason Keramidis et al.   Frontiers in Molecular Neuroscience

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

(2020) Friedel Drepper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of cysteines in accelerating Tau filament formation

(2020) Hariharakrishnan Chidambaram et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau

(2020) Yanxian Lin et al.   JOURNAL OF MOLECULAR BIOLOGY

The two Cysteines of Tau protein are functionally distinct and contribute differentially to its pathogenicity in vivo

(2020) Engie Prifti et al.   JOURNAL OF NEUROSCIENCE

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

(2020) Solomiia Boyko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine-Cysteine Interaction

(2019) Carlos Areche et al.   ChemistryOpen

Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity

(2019) Yelena Losev et al.   Scientific Reports

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation

(2019) Alessandro Didonna et al.   JOURNAL OF AUTOIMMUNITY

Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions

(2019) Solomiia Boyko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

(2019) Yanxian Lin et al.   eLife

Liquid–Liquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules

(2019) Anupa Majumdar et al.   Journal of Physical Chemistry Letters

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

(2019) Dailu Chen et al.   Nature Communications

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease

(2019) Carol J. Huseby et al.   JOURNAL OF ALZHEIMERS DISEASE

A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation

(2019) Deepa Ajit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau's N-terminal domain

(2019) Kristen M. McKibben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

(2019) Mahmood Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

(2019) Yann Fichou et al.   Frontiers in Neuroscience

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

(2019) Ebru Ercan-Herbst et al.   Acta Neuropathologica Communications

Blocking the Thiol at Cysteine-322 Destabilizes Tau Protein and Prevents Its Oligomer Formation

(2018) Hui Chen et al.   ACS Chemical Neuroscience

The Binding Mode of a Tau Peptide with Tubulin

(2018) Harindranath Kadavath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Acetylation Disfavors Tau Phase Separation

(2018) Josephine Ferreon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An N-terminal motif unique to primate tau enables differential protein–protein interactions

(2018) Kristie Stefanoska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease

(2018) Measho H. Abreha et al.   PROTEOMICS

Pathological Changes of Tau Related to Alzheimer’s Disease

(2018) Dandan Chu et al.   ACS Chemical Neuroscience

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Tau Abnormalities and the Potential Therapy in Alzheimer’s Disease

(2018) Hasan A.M.M. Almansoub et al.   JOURNAL OF ALZHEIMERS DISEASE

Phosphorylation of serine 305 in tau inhibits aggregation

(2018) Kevin H. Strang et al.   NEUROSCIENCE LETTERS

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

(2017) Marianna Karina Gorsky et al.   Scientific Reports

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

(2016) Cheng-Xin Gong et al.   Alzheimers & Dementia

Modification of Tau by 8-Nitroguanosine 3′,5′-Cyclic Monophosphate (8-Nitro-cGMP)

(2016) Jun Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action

(2016) H. Eric Feinstein et al.   JOURNAL OF NEUROCHEMISTRY

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

(2016) Marianna Karina Gorsky et al.   Scientific Reports

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

(2015) Yoshiyuki Soeda et al.   Nature Communications

Identification of disulfide cross-linked tau dimer responsible for tau propagation

(2015) Dohee Kim et al.   Scientific Reports

Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

(2015) Shaolong Zhu et al.   PLoS One

The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology

(2014) María del Carmen Cárdenas-Aguayo et al.   ACS Chemical Neuroscience

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

(2014) Amina Kamah et al.   BIOCHEMISTRY

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA Protein Granules ModulatetauIsoform Expression and Induce Neuronal Sprouting

(2014) Katharina Moschner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

(2014) Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation

(2014) Yin Luo et al.   Journal of Physical Chemistry Letters

Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation

(2014) Julius Bruch et al.   PLoS One

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau-induced neurodegeneration: mechanisms and targets

(2014) Cindy Beharry et al.   Neuroscience Bulletin

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

(2013) Rachel M. Bailey et al.   ACTA NEUROPATHOLOGICA

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

(2013) David J. Irwin et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation

(2013) Elias Akoury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The role of protein glycosylation in Alzheimer disease

(2013) Sophia Schedin-Weiss et al.   FEBS Journal

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

(2013) Alex Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

The microtubule-associated tau protein has intrinsic acetyltransferase activity

(2013) Todd J Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases

(2013) Valeriy Duka et al.   PLoS One

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering

(2013) Martin Schwalbe et al.   STRUCTURE

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations

(2012) Abhinav Nath et al.   BIOPHYSICAL JOURNAL

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

(2012) Denise Orozco et al.   EMBO REPORTS

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

(2012) Susanne Wegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

The Dynamic Structure of Filamentous Tau

(2011) Stefan Bibow et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy

(2011) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes

(2011) Martin Sadowski et al.   IUBMB LIFE

Tau Protein Assembles into Isoform- and Disulfide-dependent Polymorphic Fibrils with Distinct Structural Properties

(2011) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competing Interactions Stabilize Pro- and Anti-aggregant Conformations of Human Tau

(2011) Susanne Wegmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Kinetic Roles of the Inducer Heparin and of Rod-like Protofibrils during Amyloid Fibril Formation by Tau Protein

(2011) Gayathri Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau

(2011) Stefan Bibow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

(2011) Caroline Smet-Nocca et al.   Molecular BioSystems

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

(2010) Scott A. Yuzwa et al.   AMINO ACIDS

Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions

(2010) Tilman Grune et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

Pseudophosphorylation of tau protein directly modulates its aggregation kinetics

(2010) Edward Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Comprehensive lysine acetylomes emerging from bacteria to humans

(2010) Go-Woon Kim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis

(2008) K. J. Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA