Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization
出版年份 2022 全文链接
标题
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization
作者
关键词
-
出版物
AGING CELL
Volume 21, Issue 4, Pages -
出版商
Wiley
发表日期
2022-03-28
DOI
10.1111/acel.13596
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus
- (2021) Maheedhar Kodali et al. AGING CELL
- Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice
- (2021) Tatiana Dandolini Saccon et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Empagliflozin protects against atherosclerosis progression by modulating lipid profiles and sympathetic activity
- (2021) Yihai Liu et al. Lipids in Health and Disease
- Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway
- (2021) Shuo Zhang et al. Stem Cells International
- Metformin inhibits chronic kidney disease‐induced DNA damage and senescence of mesenchymal stem cells
- (2021) Hyoungnae Kim et al. AGING CELL
- Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function
- (2021) Qun Chen et al. Aging-US
- Metformin Attenuates ROS via FOXO3 Activation in Immune Cells
- (2021) Jelka Hartwig et al. Frontiers in Immunology
- Moving geroscience from the bench to clinical care and health policy
- (2021) Felipe Sierra et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Acarbose improved survival for Apc +/Min mice
- (2020) Sherry G. Dodds et al. AGING CELL
- Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
- (2020) Xiaofeng Feng et al. Aging-US
- Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice
- (2020) Marcelo B. Cavalcante et al. Aging-US
- Cardiovascular risk following metformin treatment in patients with type 2 diabetes mellitus: Results from meta-analysis
- (2020) Kui Zhang et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome/goblet cell/mucin axis
- (2020) Shokouh Ahmadi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells
- (2020) Huilan Wang et al. Frontiers in Oncology
- Benefits of Metformin in Attenuating the Hallmarks of Aging
- (2020) Ameya S. Kulkarni et al. Cell Metabolism
- Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
- (2020) Leena P. Bharath et al. Cell Metabolism
- SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in db/db Mice, a Model of Type 2 Diabetes
- (2020) Anton I. Korbut et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The effect of metformin on lung cancer risk and survival in patients with type 2 diabetes mellitus: A meta‐analysis
- (2020) Kang Xiao et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis
- (2020) Jian-Bo Zhou et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin
- (2020) Arantzazu Sierra-Ramirez et al. Aging-US
- Acarbose protects from central and peripheral metabolic imbalance induced by benzene exposure
- (2020) L.K. Debarba et al. BRAIN BEHAVIOR AND IMMUNITY
- SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition
- (2020) Issei Tomita et al. Cell Metabolism
- Ageing‐associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca 2+ homeostasis and promotes cardiac dysfunction
- (2020) Yusuf Olgar et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Aspirin protects melanocytes and keratinocytes against UVB-induced DNA damage in vivo
- (2020) Hafeez Rahman et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway
- (2020) Xia Zhao et al. Oxidative Medicine and Cellular Longevity
- Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis
- (2020) Xiaoqi Zhu et al. Aging-US
- Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study
- (2020) Katherine Samaras et al. DIABETES CARE
- Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging
- (2020) Young-Kyoung Ryu et al. NEUROPHARMACOLOGY
- Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure
- (2020) Milton Packer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dapagliflozin in Patients with Chronic Kidney Disease
- (2020) Hiddo J.L. Heerspink et al. NEW ENGLAND JOURNAL OF MEDICINE
- Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
- (2020) Jasper Iske et al. Nature Communications
- Canagliflozin extends lifespan in genetically heterogeneous male but not female mice
- (2020) Richard A. Miller et al. JCI Insight
- Acarbose has sex-dependent and independent effects on age-related physical function, cardiac health and lipid biology
- (2020) Jonathan J Herrera et al. JCI Insight
- Acarbose ameliorates spontaneous type‑2 diabetes in db/db mice by inhibiting PDX‑1 methylation
- (2020) Diyi Zhou et al. Molecular Medicine Reports
- Autophagy-mediated metabolic effects of aspirin
- (2020) Francesca Castoldi et al. Cell Death Discovery
- Association of metformin use with ovarian cancer incidence and prognosis: a systematic review and meta-analysis
- (2019) Jinghua Shi et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- Rapamycin and Alzheimer’s disease: Time for a clinical trial?
- (2019) Matt Kaeberlein et al. Science Translational Medicine
- Frailty index as a biomarker of lifespan and healthspan: focus on pharmacological interventions
- (2019) Dushani L. Palliyaguru et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Metformin was associated with lower all-cause mortality in type 2 diabetes with acute coronary syndrome: A Nationwide registry with propensity score-matched analysis
- (2019) Chien-Boon Jong et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Acarbose improves health and lifespan in aging HET3 mice
- (2019) David E. Harrison et al. AGING CELL
- Metformin prescription and aortic aneurysm: systematic review and meta-analysis
- (2019) Xinyu Yu et al. HEART
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- (2019) Vlado Perkovic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice
- (2019) Byron J Smith et al. BMC MICROBIOLOGY
- Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
- (2019) Joseph M. Schinaman et al. Scientific Reports
- Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial
- (2019) R. Grace Walton et al. AGING CELL
- Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
- (2019) John J.V. McMurray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Rapamycin for longevity: opinion article
- (2019) Mikhail V. Blagosklonny Aging-US
- Testing the Geroscience Hypothesis: Early Days
- (2019) Stephen B Kritchevsky et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
- (2018) Ameya S Kulkarni et al. AGING CELL
- Gene Expression-Based Drug Repurposing to Target Ageing
- (2018) Handan Melike Dönertaş et al. AGING CELL
- A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects
- (2018) Ellen Kraig et al. EXPERIMENTAL GERONTOLOGY
- Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα
- (2018) Sujyoti Chandra et al. JOURNAL OF NEUROSCIENCE
- SGLT-2 Inhibitors and Cardiovascular Risk
- (2018) Matthew A. Cavender et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- TORC1 inhibition enhances immune function and reduces infections in the elderly
- (2018) Joan B. Mannick et al. Science Translational Medicine
- Aspirin Recapitulates Features of Caloric Restriction
- (2018) Federico Pietrocola et al. Cell Reports
- Metformin and Risk of Hypertension in Taiwanese Patients With Type 2 Diabetes Mellitus
- (2018) Chin‐Hsiao Tseng Journal of the American Heart Association
- Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
- (2018) Hao Zhou et al. Redox Biology
- N-acetyl L-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging
- (2018) Geetika Garg et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis
- (2018) Jared M. Campbell et al. JOURNAL OF ALZHEIMERS DISEASE
- Chronic treatment with the ACE inhibitor enalapril attenuates the development of frailty and differentially modifies pro-and anti-inflammatory cytokines in aging male and female C57BL/6 mice
- (2018) Kaitlyn Keller et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
- (2018) John J. McNeil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
- (2018) NEW ENGLAND JOURNAL OF MEDICINE
- N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model
- (2018) Aurore Marie et al. Aging and Disease
- Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice
- (2018) Clara Correia-Melo et al. AGING CELL
- Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells
- (2018) Xiaokun Lin et al. BIOSCIENCE REPORTS
- A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats
- (2018) Aysegul Durak et al. Cardiovascular Diabetology
- Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel
- (2018) Xiaoli Zhang et al. NEUROLOGICAL RESEARCH
- Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
- (2018) Stephen D. Wiviott et al. NEW ENGLAND JOURNAL OF MEDICINE
- N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model
- (2018) Jamileth More et al. Frontiers in Aging Neuroscience
- mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
- (2017) Vivian A. Paschoal et al. IMMUNOBIOLOGY
- Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
- (2017) Gordon K. Wilcock et al. JOURNAL OF ALZHEIMERS DISEASE
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
- (2017) Bruce Neal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Angiotensin II receptor blockers induce autophagy in prostate cancer cells
- (2017) Yunseo Woo et al. Oncology Letters
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial
- (2017) Rury R Holman et al. Lancet Diabetes & Endocrinology
- Long-term use of angiotensin-converting enzyme inhibitors protects against bone loss in African-American elderly men
- (2017) Nahid Rianon et al. Archives of Osteoporosis
- NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model
- (2017) Nancy L. Nadon et al. EBioMedicine
- Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease
- (2017) Viktor Martyanov et al. PLoS One
- Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
- (2017) Zheng-Mei Xiong et al. Scientific Reports
- Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer
- (2016) Randy Strong et al. AGING CELL
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- Rapamycin alleviates oxidative stress-induced damage in rat erythrocytes
- (2016) Abhishek Kumar Singh et al. Biochemistry and Cell Biology
- Risks of cardiovascular diseases associated with dipeptidyl peptidase-4 inhibitors and other antidiabetic drugs in patients with type 2 diabetes: a nation-wide longitudinal study
- (2016) Huang-Tz Ou et al. Cardiovascular Diabetology
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- N -acetylcysteine protects memory decline induced by streptozotocin in mice
- (2016) Michael Costa et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Cardiovascular safety of glucose-lowering agents as add-on medication to metformin treatment in type 2 diabetes: report from the Swedish National Diabetes Register
- (2016) Nils Ekström et al. DIABETES OBESITY & METABOLISM
- The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE −/− mice fed a western diet
- (2016) Ji Hye Han et al. DIABETOLOGIA
- Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial
- (2016) José A. Luchsinger et al. JOURNAL OF ALZHEIMERS DISEASE
- Cardiovascular and cerebrovascular outcomes of long-term angiotensin receptor blockade: meta-analyses of trials in essential hypertension
- (2016) Leo Akioyamen et al. Journal of the American Society of Hypertension
- Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience
- (2016) Derek M. Huffman et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients Without Heart Failure? Insights From 254,301 Patients From Randomized Trials
- (2016) Sripal Bangalore et al. MAYO CLINIC PROCEEDINGS
- The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/−Mice
- (2016) Weiling Leng et al. MEDIATORS OF INFLAMMATION
- Articulating the Case for the Longevity Dividend
- (2016) S. Jay Olshansky Cold Spring Harbor Perspectives in Medicine
- Metformin: A Hopeful Promise in Aging Research
- (2016) Marta G. Novelle et al. Cold Spring Harbor Perspectives in Medicine
- Effect of Acarbose on Long-Term Prognosis in Acute Coronary Syndromes Patients with Newly Diagnosed Impaired Glucose Tolerance
- (2016) Peng Yun et al. Journal of Diabetes Research
- Systematic Review with Network Meta-Analysis: Antidiabetic Medication and Risk of Hepatocellular Carcinoma
- (2016) Yao-Yao Zhou et al. Scientific Reports
- Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria
- (2015) Zheng-Mei Xiong et al. AGING CELL
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice
- (2015) Jing-Jing Tong et al. BEHAVIOURAL BRAIN RESEARCH
- Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8
- (2015) Wen-Wen Yan et al. BRAIN RESEARCH
- Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers therapy and colorectal cancer: a systematic review and meta-analysis
- (2015) Yi-Ning Dai et al. CANCER CAUSES & CONTROL
- Impact of renin–angiotensin system inhibitors on mortality and major cardiovascular endpoints in hypertension: A number-needed-to-treat analysis
- (2015) Jasper J. Brugts et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effects of blood pressure lowering on outcome incidence in hypertension
- (2015) Costas Thomopoulos et al. JOURNAL OF HYPERTENSION
- Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model
- (2015) Aya Zakaria et al. MOLECULAR NEUROBIOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
- (2015) Bernard Zinman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders
- (2014) S. Gandini et al. Cancer Prevention Research
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
- (2014) C. A. Bannister et al. DIABETES OBESITY & METABOLISM
- Advances in Geroscience: Impact on Healthspan and Chronic Disease
- (2014) J. B. Burch et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis
- (2014) Chin Cheng et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium
- (2014) O V Leontieva et al. Cell Death & Disease
- Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
- (2013) David E. Harrison et al. AGING CELL
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
- (2013) Richard A. Miller et al. AGING CELL
- Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts
- (2013) Bidisha Saha et al. AGING CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin
- (2013) E. M. Moore et al. DIABETES CARE
- Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
- (2013) Suzanne Oparil et al. HYPERTENSION
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Rapamycin Reduces Reactive Oxygen Species in Cultured Human Corneal Endothelial Cells
- (2012) Young Joo Shin et al. CURRENT EYE RESEARCH
- The Critical Role of Metabolic Pathways in Aging
- (2012) N. Barzilai et al. DIABETES
- Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease
- (2012) J. Hong et al. DIABETES CARE
- Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials
- (2012) R. J. Stevens et al. DIABETOLOGIA
- Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158 998 patients
- (2012) L. C. van Vark et al. EUROPEAN HEART JOURNAL
- Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan
- (2012) Chin-Hsiao Tseng EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC)
- (2012) Jinmiao Liu et al. HUMAN REPRODUCTION
- A Meta-Analysis Reporting Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients Without Heart Failure
- (2012) Gianluigi Savarese et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study
- (2012) Patrick Imfeld et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
- (2012) Ömer H. Yilmaz et al. NATURE
- N-acetylcysteine reverses existing cognitive impairment and increased oxidative stress in glutamate transporter type 3 deficient mice
- (2012) L. Cao et al. NEUROSCIENCE
- Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice
- (2012) Masato Hosokawa et al. PLoS One
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis
- (2012) D. Caldeira et al. BMJ-British Medical Journal
- Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers and Diabetes: A Meta-Analysis of Placebo-Controlled Clinical Trials
- (2011) G. Tocci et al. AMERICAN JOURNAL OF HYPERTENSION
- Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals
- (2011) Meei-Shyuan Lee et al. BMC CANCER
- Effects of renin–angiotensin system blockades on cardiovascular outcomes in patients with diabetes mellitus: A systematic review and meta-analysis
- (2011) Yoko M. Nakao et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes
- (2011) Hermann Haller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice
- (2010) Chong Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice
- (2010) K. Flurkey et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
- (2010) Richard A. Miller et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events
- (2010) NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair
- (2010) Honghong Chen et al. RADIATION RESEARCH
- Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension
- (2009) Kaycee M. Sink et al. ARCHIVES OF INTERNAL MEDICINE
- Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats
- (2009) Edson Lucas Santos et al. BIOCHEMICAL PHARMACOLOGY
- Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16
- (2009) G. W.D. Landman et al. DIABETES CARE
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
- (2008) Randy Strong et al. AGING CELL
- Systemic exposure of everolimus after stent implantation: A pharmacokinetic study
- (2008) Marcus Wiemer et al. AMERICAN HEART JOURNAL
- Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging
- (2008) Hélène Bulckaen et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Effects of Losartan in Women With Hypertension and Left Ventricular Hypertrophy
- (2008) Ingrid Os et al. HYPERTENSION
- Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
- (2007) Hani Atamna et al. FASEB JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started