A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats

(2018) Piangkwan Sa-nguanmoo et al.   BIOMEDICINE & PHARMACOTHERAPY

Potential mechanisms responsible for cardioprotective effects of sodium–glucose co-transporter 2 inhibitors

(2018) Sarayut Lahnwong et al.   Cardiovascular Diabetology

Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance

(2018) Yusuf Olgar et al.   EXPERIMENTAL GERONTOLOGY

Beneficial Effect of the SGLT2 Inhibitor Empagliflozin on Glucose Homeostasis and Cardiovascular Parameters in the Cohen Rosenthal Diabetic Hypertensive (CRDH) Rat

(2018) Firas Younis et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Cytosolic increased labile Zn 2+ contributes to arrhythmogenic action potentials in left ventricular cardiomyocytes through protein thiol oxidation and cellular ATP depletion

(2018) Sinan Degirmenci et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts

(2017) Tsung-Ming Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury

(2017) Pongpan Tanajak et al.   JOURNAL OF ENDOCRINOLOGY

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

(2017) Alyssa Faria et al.   PHARMACOLOGY & THERAPEUTICS

Interplay Between Cytosolic Free Zn2+ and Mitochondrion Morphological Changes in Rat Ventricular Cardiomyocytes

(2016) Deniz Billur et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis

(2016) Christian Sonesson et al.   Cardiovascular Diabetology

Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome

(2016) Hiroaki Kusaka et al.   Cardiovascular Diabetology

ROS and intracellular ion channels

(2016) Kirill Kiselyov et al.   CELL CALCIUM

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits

(2016) Antonius Baartscheer et al.   DIABETOLOGIA

Mitochondrial Dynamics in Diabetic Cardiomyopathy

(2015) Chad A. Galloway et al.   ANTIOXIDANTS & REDOX SIGNALING

Intracellular Zn2+ Increase in Cardiomyocytes Induces both Electrical and Mechanical Dysfunction in Heart via Endogenous Generation of Reactive Nitrogen Species

(2015) Erkan Tuncay et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Profiling of cardiac β-adrenoceptor subtypes in the cardiac left ventricle of rats with metabolic syndrome: Comparison with streptozotocin-induced diabetic rats

(2015) Esma N. Okatan et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intracellular Na+Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+–Glucose Cotransport

(2015) Rebekah Lambert et al.   Journal of the American Heart Association

Nitric oxide and mitochondria in metabolic syndrome

(2015) Larisa Litvinova et al.   Frontiers in Physiology

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Targeting Mitochondria for Cardiac Protection

(2013) Sauri Hernandez-Resendiz et al.   CURRENT DRUG TARGETS

Cardiac Dysfunction and Oxidative Stress in the Metabolic Syndrome: an Update on Antioxidant Therapies

(2013) Olesya Ilkun et al.   CURRENT PHARMACEUTICAL DESIGN

Intracellular Levels of Na+ and TTX-sensitive Na+ Channel Current in Diabetic Rat Ventricular Cardiomyocytes

(2012) Ayca Bilginoglu et al.   Cardiovascular Toxicology

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin E in Oxidant Stress-Related Cardiovascular Pathologies: Focus on Experimental Studies

(2011) Belma Turan et al.   CURRENT PHARMACEUTICAL DESIGN

Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant

(2011) Tanecia Mitchell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Role of Antioxidants in Diabetes-Induced Cardiac Dysfunction

(2010) Guy Vassort et al.   Cardiovascular Toxicology

High prevalence of early repolarization in short QT syndrome

(2010) Hiroshi Watanabe et al.   HEART RHYTHM

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Relationship of Hemoglobin A1C and Mortality in Heart Failure Patients With Diabetes

(2009) David Aguilar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

(2008) S. Han et al.   DIABETES