SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in db/db Mice, a Model of Type 2 Diabetes

Interplay of adenosine monophosphate‐activated protein kinase/sirtuin‐1 activation and sodium influx inhibition mediates the renal benefits of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes: A novel conceptual framework

(2020) Milton Packer   DIABETES OBESITY & METABOLISM

Autophagy Function and Regulation in Kidney Disease

(2020) Gur P. Kaushal et al.   Biomolecules

Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy

(2019) Eun-Jung Lee et al.   Nutrients

Autophagy in Chronic Kidney Diseases

(2019) Tien-An Lin et al.   Cells

Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon

(2019) Keizo Kanasaki et al.   Frontiers in Pharmacology

LC3-positive structures are prominent in autophagy-deficient cells

(2019) Gautam Runwal et al.   Scientific Reports

Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride

(2019) Yung-Ho Hsu et al.   Cells

Kr�ppel‑like factor�4 ameliorates diabetic kidney disease by activating autophagy via the mTOR pathway

(2019) Jianguang Gong et al.   Molecular Medicine Reports

More than just an enzyme: Dipeptidyl peptidase-4 (DPP-4) and its association with diabetic kidney remodelling

(2019) Shreyasi Gupta et al.   PHARMACOLOGICAL RESEARCH

The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells

(2019) Mai Shi et al.   CELLULAR SIGNALLING

Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells

(2018) Chenke Xu et al.   BIOCHEMICAL PHARMACOLOGY

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

(2018) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

SGLT2 inhibition and kidney protection

(2018) Josselin Nespoux et al.   CLINICAL SCIENCE

Renal outcomes with dipeptidyl peptidase-4 inhibitors

(2018) A.J. Scheen et al.   DIABETES & METABOLISM

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

Methods in renal research: Measurement of autophagic flux in the renal cortex ex vivo

(2018) Gavin C. Higgins et al.   NEPHROLOGY

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

(2018) Yingmei Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice

(2018) Wenbin Zheng et al.   International Journal of Endocrinology

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy

(2018) Ji Hee Lim et al.   Cell Death & Disease

Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy

(2018) Silvia Maestroni et al.   ACTA DIABETOLOGICA

Dysregulation of lncRNAs GM5524 and GM15645 involved in high‑glucose‑induced podocyte apoptosis and autophagy in diabetic nephropathy

(2018) Yamin Feng et al.   Molecular Medicine Reports

Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat

(2018) Chih-Chao Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats

(2018) Yi Zhou et al.   CARDIOVASCULAR DRUGS AND THERAPY

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk

(2018) Julio Rosenstock et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tips for Studies with Quantitative Morphology (Morphometry and Stereology)

(2017) Carlos Alberto Mandarim-de-Lacerda et al.   INTERNATIONAL JOURNAL OF MORPHOLOGY

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Viability of primary cultured podocytes is associated with extracellular high glucose-dependent autophagy downregulation

(2017) Irena Audzeyenka et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Apelin involved in progression of diabetic nephropathy by inhibiting autophagy in podocytes

(2017) Yu Liu et al.   Cell Death & Disease

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

(2017) Haoran Dai et al.   Journal of Diabetes Research

Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy

(2017) Na Liu et al.   Journal of Diabetes Research

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus

(2016) Yu. S. Gavrilova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Podocytes: the Weakest Link in Diabetic Kidney Disease?

(2016) Jamie S. Lin et al.   Current Diabetes Reports

SGLT2 Inhibitors and the Diabetic Kidney

(2016) Paola Fioretto et al.   DIABETES CARE

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance

(2016) Wei Xin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging role of podocyte autophagy in the progression of diabetic nephropathy

(2015) Mako Yasuda-Yamahara et al.   Autophagy

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats

(2015) Hiromichi Murase et al.   Cardiovascular Diabetology

Insulin signaling

(2015) Richard Coward et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

(2015) Chenglong Dong et al.   EXPERIMENTAL CELL RESEARCH

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

(2015) Lili Zhou et al.   Nature Reviews Nephrology

Autophagy in renal diseases

(2015) Stéphanie De Rechter et al.   PEDIATRIC NEPHROLOGY

To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells

(2014) Eeva-Liisa Eskelinen   Autophagy

Liraglutide inhibits autophagy and apoptosis induced by high glucose through GLP-1R in renal tubular epithelial cells

(2014) X ZHAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Blood pressure and glucose independent renoprotective effects of dipeptidyl peptidase-4 inhibition in a mouse model of type-2 diabetic nephropathy

(2014) Yuliya Sharkovska et al.   JOURNAL OF HYPERTENSION

Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation

(2014) Zhong-Hui Wang et al.   TheScientificWorldJOURNAL

Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy

(2013) J. Guzman et al.   DIABETES

mTOR Signaling in Autophagy Regulation in the Kidney

(2013) Ken Inoki   SEMINARS IN NEPHROLOGY

Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis

(2013) Yan Ding et al.   SEMINARS IN NEPHROLOGY

Techniques in Electron Microscopy of Animal Tissue

(2013) N. F. Cheville et al.   VETERINARY PATHOLOGY

Neuroendocrine regulation of autophagy by leptin

(2011) Shoaib Ahmad Malik et al.   CELL CYCLE

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell