Chemo-Enzymatic Modification of the 5′ Cap To Study mRNAs

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

(2021) Melissa Dülmen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible‐Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases

(2021) Aileen Peters et al.   CHEMBIOCHEM

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation

(2021) Radoslaw Wojcik et al.   Pharmaceutics

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

(2020) Alison Galloway et al.   Open Biology

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Tag‐free internal RNA labeling and photocaging based on mRNA methyltransferases

(2020) Anna Ovcharenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions

(2020) Freideriki Michailidou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells

(2019) Lea Anhäuser et al.   NUCLEIC ACIDS RESEARCH

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

(2019) Jan Mauer et al.   Nature Chemical Biology

Combining chemical synthesis and enzymatic methylation to access short RNAs with various 5′ caps

(2019) Nils Muthmann et al.   CHEMBIOCHEM

Enzymatic Synthesis of Base-Functionalized Nucleic Acids for Sensing, Cross-linking, and Modulation of Protein–DNA Binding and Transcription

(2019) Michal Hocek   ACCOUNTS OF CHEMICAL RESEARCH

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA

(2019) Bastian Linder et al.   Cold Spring Harbor Perspectives in Biology

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

A benzophenone-based photocaging strategy for the N7 position of guanosine

(2019) Lea Anhäuser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic or In Vivo Installation of Propargyl Groups in Combination with Click Chemistry for the Enrichment and Detection of Methyltransferase Target Sites in RNA

(2018) Katja Hartstock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

(2018) Ilona Kocmik et al.   CELL CYCLE

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

(2018) Hanxiao Sun et al.   CELL RESEARCH

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation

(2017) F. Muttach et al.   Chemical Science

Modifying the 5′-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells

(2016) Josephin M. Holstein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore

(2016) György Dormán et al.   CHEMICAL REVIEWS

One-pot modification of 5′-capped RNA based on methionine analogs

(2016) Fabian Muttach et al.   METHODS

A Biocatalytic Cascade for Versatile One-Pot Modification of mRNA Starting from Methionine Analogues

(2015) Fabian Muttach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic modification of 5′-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels–Alder reaction

(2015) Josephin Marie Holstein et al.   Chemical Science

A sensitive mass spectrum assay to characterize engineered methionine adenosyltransferases with S-alkyl methionine analogues as substrates

(2014) Rui Wang et al.   ANALYTICAL BIOCHEMISTRY

Bioorthogonal site-specific labeling of the 5′-cap structure in eukaryotic mRNAs

(2014) Josephin Marie Holstein et al.   CHEMICAL COMMUNICATIONS

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

A Chemo-Enzymatic Approach for Site-Specific Modification of the RNA Cap

(2013) Daniela Schulz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photo-induced covalent cross-linking for the analysis of biomolecular interactions

(2013) George W. Preston et al.   CHEMICAL SOCIETY REVIEWS

A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells

(2013) Rui Wang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation

(2013) K. Islam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and evaluation of fluorescent cap analogues for mRNA labelling

(2013) Marcin Ziemniak et al.   RSC Advances

Current Chemical Biology Approaches to Interrogate Protein Methyltransferases

(2012) Minkui Luo   ACS Chemical Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Profiling Genome-Wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells

(2012) Rui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

An enzyme-coupled high-throughput assay for screening RNA methyltransferase activity inE. Colicell lysate

(2012) Daniela Schulz et al.   RNA Biology

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

2′-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family

(2011) Maria Werner et al.   NUCLEIC ACIDS RESEARCH

Enzymatic Site-Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling

(2010) Wibke Peters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase

(2010) François Bélanger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Enzymology of RNA cap synthesis

(2010) Agnidipta Ghosh et al.   Wiley Interdisciplinary Reviews-RNA

Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1

(2009) Thomas Monecke et al.   NUCLEIC ACIDS RESEARCH