Recent Progress toward the Construction of Axially Chiral Molecules Catalyzed by an N-heterocyclic Carbene

N‐Heterocyclic Carbene‐Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C‐N Axial Chirality

(2021) Tingting Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Axially Chiral Compounds

(2021) Bing‐Chao Da et al.   CHINESE JOURNAL OF CHEMISTRY

NHC‐Catalyzed Desymmetrization of N‐Aryl Maleimides Leading to the Atroposelective Synthesis of N‐Aryl Succinimides

(2021) Soumen Barik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to Allene‐Containing Molecules via Enantioselective Reactions of Azolium Cumulenolate Intermediates

(2021) Yongtao Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Axially Chiral Benzothiophene/Benzofuran‐Fused Biaryls by N‐Heterocyclic Carbene Catalyzed Arene Formation

(2021) Chun‐Lin Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of Silicon‐Stereogenic Dihydrodibenzosilines: Silicon Central‐to‐Axial Chirality Relay

(2021) Yonghong Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Atroposelective Synthesis of Axially Chiral 4-Aryl α-Carbolines via N-Heterocyclic Carbene Catalysis

(2021) Rui Ma et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Asymmetric Synthesis of Cyclopentenones

(2021) Zhizhou Chen et al.   ORGANIC LETTERS

Carbene-Catalyzed Atroposelective Annulation and Desymmetrization of Urazoles

(2021) Jiamiao Jin et al.   ORGANIC LETTERS

A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions

(2021) Fangfang Guo et al.   ACS Catalysis

An axial-to-axial chirality transfer strategy for atroposelective construction of C–N axial chirality

(2021) Ze-Shui Liu et al.   Chem

Carbene‐Catalyzed Asymmetric Construction of Atropisomers

(2021) Runjiang Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atroposelective Synthesis of Conjugated Diene-Based Axially Chiral Styrenes via Pd(II)-Catalyzed Thioether-Directed Alkenyl C–H Olefination

(2021) Liang Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Axially Chiral Styrenes through Pd-Catalyzed Asymmetric C−H Olefination Enabled by an Amino Amide Transient Directing Group

(2020) Hong Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Research progress on the catalytic enantioselective synthesis of axially chiral allenes by chiral organocatalysts

(2020) Xin Jiang et al.   CURRENT ORGANIC CHEMISTRY

Organocatalyzed Kinetic Resolution of α-Functionalized Ketones: The Malonate Unit Leads the Way

(2020) Jian Liu et al.   ACS Catalysis

Atroposelective Synthesis of Axially Chiral Styrenes via an Asymmetric C–H Functionalization Strategy

(2020) Liang Jin et al.   Chem

Catalytic, Enantioselective C2-Functionalization of 3-Aminobenzofurans Using N-Heterocyclic Carbenes

(2020) Shilpa Barik et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Based Catalysis Enabling Cross-Coupling Reactions

(2020) Hirohisa Ohmiya   ACS Catalysis

Atroposelective Access to Oxindole-Based Axially Chiral Styrenes via the Strategy of Catalytic Kinetic Resolution

(2020) Chun Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Discovery of Multifunctional Chiral P Ligands for the Catalytic Construction of Quaternary Carbon/Silicon and Multiple Stereogenic Centers

(2020) Fei Ye et al.   ACCOUNTS OF CHEMICAL RESEARCH

NHC-Catalyzed Generation of α,β-Unsaturated Acylazoliums for the Enantioselective Synthesis of Heterocycles and Carbocycles

(2019) Santigopal Mondal et al.   ACCOUNTS OF CHEMICAL RESEARCH

Allenation of Terminal Alkynes with Aldehydes and Ketones

(2019) Xin Huang et al.   ACCOUNTS OF CHEMICAL RESEARCH

NHC-Catalyzed Atroposelective Acylation of Phenols: Access to Enantiopure NOBIN Analogs by Desymmetrization

(2019) Shenci Lu et al.   ORGANIC LETTERS

NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

(2019) Gongming Yang et al.   Nature Communications

Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition

(2019) Ke Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereo- and Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade

(2019) Shenci Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Synthesis of Indole-Based Chiral Heterocycles: Strategies, Reactions, and Outreach

(2019) Yu-Chen Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

(2018) Yong-Bin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Remote Enantioselective Functionalizations

(2018) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent encounters with atropisomerism in drug discovery

(2018) Peter W. Glunz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

(2018) Yangxi Xie et al.   CHEMICAL COMMUNICATIONS

Stereoselective arene formation

(2018) Achim Link et al.   CHEMICAL SOCIETY REVIEWS

Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor

(2018) Jayaraman Chandrasekhar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Enantioselective [5 + 2] Annulations through Cooperative N-Heterocyclic Carbene (NHC) Organocatalysis and Palladium Catalysis

(2018) Santanu Singha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes

(2018) Changgui Zhao et al.   Nature Communications

Catalyst-Controlled Stereoselective Synthesis of Atropisomers

(2018) Bouthayna Zilate et al.   ACS Catalysis

N-Heterocyclic Carbene-Catalyzed in situ Activation of Alkynyl Acids for C-S Bond Formation: Access to Imidazo[2,1-b][1,3]thiazinones

(2018) Ding Du et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective N-Heterocyclic Carbene-Catalyzed Kinetic Resolution of Anilides

(2018) Jianbo Bie et al.   ORGANIC LETTERS

Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity

(2018) Anthony J. Metrano et al.   ACCOUNTS OF CHEMICAL RESEARCH

Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form

(2017) Hidetsugu Tabata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

(2017) Vivek S. Raut et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal–Knorr Reaction

(2017) Lei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic asymmetric arylation of indoles enabled by azo groups

(2017) Liang-Wen Qi et al.   Nature Chemistry

Organocatalytic atroposelective synthesis of axially chiral styrenes

(2017) Sheng-Cai Zheng et al.   Nature Communications

Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

(2017) Yong-Bin Wang et al.   Nature Communications

N-Heterocyclic Carbene Catalysis via the α,β-Unsaturated Acyl Azolium

(2017) Changhe Zhang et al.   ACS Catalysis

Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights

(2016) Guoxiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphoric Acid-Catalyzed Asymmetric Synthesis of SPINOL Derivatives

(2016) Shaoyu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Enantioselective Umpolung Annulations

(2016) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives

(2016) Jin-Zheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction

(2016) Ji-Wei Zhang et al.   Nature Communications

Chiral Monophosphorus Ligands for Asymmetric Catalytic Reactions

(2016) Wenzhen Fu et al.   ACS Catalysis

Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines

(2015) Ophélie Quinonero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins

(2015) Leming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Stronger Brønsted Acids: Recent Progress

(2015) Takahiko Akiyama et al.   CHEMICAL REVIEWS

Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions

(2015) Rajeev S. Menon et al.   CHEMICAL SOCIETY REVIEWS

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

(2015) J. Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

Catalytic Kinetic Resolution of Biaryl Compounds

(2015) Gaoyuan Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2-Naphthols

(2015) Ye-Hui Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A twist of nature – the significance of atropisomers in biological systems

(2015) Jamie E. Smyth et al.   NATURAL PRODUCT REPORTS

Highly enantioselective sulfa-Michael addition reactions using N-heterocyclic carbene as a non-covalent organocatalyst

(2015) Jiean Chen et al.   Chemical Science

N-Heterocyclic carbene catalysed redox isomerisation of esters to functionalised benzaldehydes

(2015) Lisa Candish et al.   Chemical Science

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid

(2014) Dao-Juan Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Resolution of 1,1′-Biaryl-2,2′-Diols and Amino Alcohols through NHC-Catalyzed Atroposelective Acylation

(2014) Shenci Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric catalysis with N-heterocyclic carbenes as non-covalent chiral templates

(2014) Jiean Chen et al.   Nature Communications

Conquering three-carbon axial chirality of allenes

(2014) Juntao Ye et al.   Organic Chemistry Frontiers

P,N ligands in asymmetric catalysis

(2013) Michael P. Carroll et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Synthesis of Multisubstituted Biaryl Skeleton by Chiral Phosphoric Acid Catalyzed Desymmetrization/Kinetic Resolution Sequence

(2013) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Internal Redox Reaction of Alkynals: An Efficient Synthesis of Allenoates

(2012) Yu-Ming Zhao et al.   ORGANIC LETTERS

Extending NHC-Catalysis: Coupling Aldehydes with Unconventional Reaction Partners

(2011) Akkattu T. Biju et al.   ACCOUNTS OF CHEMICAL RESEARCH

How easy are the syntheses of allenes?

(2011) Shichao Yu et al.   CHEMICAL COMMUNICATIONS

Low-loading asymmetric organocatalysis

(2011) Francesco Giacalone et al.   CHEMICAL SOCIETY REVIEWS

Assessing Atropisomer Axial Chirality in Drug Discovery and Development

(2011) Steven R. LaPlante et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

The Challenge of Atropisomerism in Drug Discovery

(2009) Jonathan Clayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of chiral biaryl natural products by asymmetric biaryl coupling

(2009) Marisa C. Kozlowski et al.   CHEMICAL SOCIETY REVIEWS

Chiral Diphosphine and Monodentate Phosphorus Ligands on a Spiro Scaffold for Transition-Metal-Catalyzed Asymmetric Reactions

(2008) Jian-Hua Xie et al.   ACCOUNTS OF CHEMICAL RESEARCH