Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions

Functionalized cyclopentenes through a tandem NHC-catalyzed dynamic kinetic resolution and ambient temperature decarboxylation: mechanistic insight and synthetic application

(2015) Daniel T. Cohen et al.   CHEMICAL COMMUNICATIONS

N-Heterocyclic Carbene-Catalyzed Diastereoselective and Enantioselective Reaction of 2-Aroylvinylcinnamaldehydes with α,β-Unsaturated Imines: Complete Control and Switch of Diastereoselectivity by N-Substituents of Catalysts

(2015) Zi-Tian Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Access to Oxoquinoline Heterocycles by N-Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone

(2014) Zhenqian Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Cooperative N-Heterocyclic Carbene/Chiral Phosphate Catalysis System for Allenolate Annulations

(2014) Anna Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Functionalization of Carboxylic Anhydrides with β-Alkyl Substituents through Carbene Organocatalysis

(2014) Zhichao Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Formal [3+2] Annulation Reaction of Enals: An Efficient Enantioselective Access to Spiro-Heterocycles

(2014) Chang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters

(2014) Jun-Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

(2014) Min Wang et al.   CHEMICAL COMMUNICATIONS

Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation

(2014) C. Guy Goodman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene Catalyzed Annulation of Enals to Aurone Analogs: Synthesis of Cyclopentene-Fused Spirobenzofuran-3-ones

(2014) K. C. Seetha Lakshmi et al.   ORGANIC LETTERS

A Novel Intramolecular Homoenolate Annulation Leading to the Formation of Cyclopentene-Fused Macrocycles

(2014) K. C. Seetha Lakshmi et al.   ORGANIC LETTERS

A cooperative N-heterocyclic carbene/palladium catalysis system

(2014) Kun Liu et al.   Chemical Science

N-Heterocyclic Carbene Catalyzed [4+3] Annulation of Enals ando-Quinone Methides: Highly Enantioselective Synthesis of Benzo-ε-Lactones

(2013) Hui Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis

(2013) Adel M. ElSohly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of the Key Intermediates of Carbene-Catalyzed Umpolung by NMR Spectroscopy and X-Ray Diffraction: Breslow Intermediates, Homoenolates, and Azolium Enolates

(2013) Albrecht Berkessel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective N-Heterocyclic Carbene Catalyzed Annulation Reactions with Imidazolidinones

(2013) Elizabeth O'Bryan McCusker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene (NHC)-Catalyzed/Lewis Acid Mediated Conjugate Umpolung of Alkynyl Aldehydes for the Synthesis of Butenolides: A Formal [3+2] Annulation

(2013) Jing Qi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalysis with N-Heterocyclic Carbenes under Oxidative Conditions

(2013) Suman De Sarkar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric N-Heterocyclic Carbene Catalyzed Addition of Enals to Nitroalkenes: Controlling Stereochemistry via the Homoenolate Reactivity Pathway To Access δ-Lactams

(2013) Nicholas A. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations

(2013) Javier Izquierdo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Homoenolate Additions to Acyl Phosphonates through Rational Design of a Tailored N-Heterocyclic Carbene Catalyst

(2013) Ki Po Jang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

(2013) Zhenqian Fu et al.   Nature Chemistry

N-heterocyclic carbene catalyzed annulation of benzofuran-2,3-diones and enals: a concise synthesis of spiro-bis-lactone

(2013) Ze-Dong Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-mediated cross-coupling of sugar-derived cyclic nitrones with enals: general and efficient synthesis of polyhydroxylated pyrrolizidines and indolizidines

(2013) Wen-Yuan Xu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene-catalyzed cascade reaction of 2-aroylvinylcinnamaldehydes with 2-aroylvinylchalcones: rapid assembly of six contiguous stereogenic centers with high diastereoselectivity

(2013) Xing-Wen Fan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-Catalyzed Reaction of Enals with Hydroxy Chalcones: Diastereoselective Synthesis of Functionalized Coumarins

(2013) Anup Bhunia et al.   ORGANIC LETTERS

N-Heterocyclic Carbene Catalyzed Reaction of Cinnamils Leading to the Formation of 2,3,8-Triaryl Vinyl Fulvenes: An Uncommon Transformation

(2013) C. R. Sinu et al.   ORGANIC LETTERS

Exploiting Acyl and Enol Azolium Intermediates via N-Hetero- cyclic Carbene-Catalyzed Reactions of α-Reducible Aldehydes

(2012) Harit U. Vora et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed Homoenolate-Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5-Carbon-Synthon δ-Nitroesters

(2012) Biswajit Maji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

(2012) Julien Dugal-Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Dynamic Kinetic Resolutions with N-Heterocyclic Carbenes: Asymmetric Synthesis of Highly Substituted β-Lactones

(2012) Daniel T. Cohen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones

(2012) Atul K. Singh et al.   CHEMICAL COMMUNICATIONS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene-Catalyzed Homoenolate Additions with N-Aryl Ketimines as Electrophiles: Efficient Synthesis of Spirocyclic γ-Lactam Oxindoles

(2012) Bo Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Cascade Reaction Actuated by Nucleophilic Heterocyclic Carbene Catalyzed Intramolecular Addition of Enals via Homoenolate to α,β-Unsaturated Esters: Efficient Synthesis of Coumarin Derivatives

(2012) C. R. Sinu et al.   ORGANIC LETTERS

Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines

(2012) Kun Jiang et al.   ORGANIC LETTERS

Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams

(2012) Hui Lv et al.   ORGANIC LETTERS

A Highly Regio- and Stereoselective Cascade Annulation of Enals and Benzodi(enone)s Catalyzed by N-Heterocyclic Carbenes

(2011) Xinqiang Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins

(2011) Li-Hui Sun et al.   CHEMICAL COMMUNICATIONS

Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene and Brønsted Acid Cooperative Catalysis: Asymmetric Synthesis oftrans-γ-Lactams

(2011) Xiaodan Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel NHC-catalyzed transformation of 2H-chromene-3-carboxaldehydes to 3-methyl-2H-chromen-2-ones

(2011) Vijay Nair et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

(2010) Vijay Nair et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Novel Nucleophilic Heterocyclic Carbene Mediated Stereoselective Conjugate Addition of Enals to Nitrostyrenes via Homoenolate§

(2009) Vijay Nair et al.   ORGANIC LETTERS

Recent advances in carbon–carbon bond-forming reactions involving homoenolates generated by NHC catalysis

(2008) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS