N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

Direct and Enantioselective Synthesis of N−H-Free 1,5-Benzodiazepin-2-ones by an N-Heterocyclic Carbene Catalyzed [3+4] Annulation Reaction

(2018) Chao Fang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes

(2018) Changgui Zhao et al.   Nature Communications

Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

(2017) Pei-Zhi Zhang et al.   GREEN CHEMISTRY

Organocatalytic Direct N-Acylation of Amides with Aldehydes under Oxidative Conditions

(2017) Chenguang Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Esters as Alkynyl Acyl Ammonium and Azolium Precursors: A Formal [2 + 3] Annulation with Amidomalonates via Lewis Base/Lewis Acid Cooperative Catalysis

(2017) Jing Cao et al.   ORGANIC LETTERS

Formal [3 + 4] Annulation of α,β-Unsaturated Acyl Azoliums: Access to Enantioenriched N–H-Free 1,5-Benzothiazepines

(2017) Chao Fang et al.   ORGANIC LETTERS

N-Heterocyclic Carbene Catalysis via the α,β-Unsaturated Acyl Azolium

(2017) Changhe Zhang et al.   ACS Catalysis

Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions

(2016) Xingxing Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family

(2016) Cristina Tintori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

(2016) I. A. Novakov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene Catalyzed Synthesis of δ-Sultones via α,β-Unsaturated Sulfonyl Azolium Intermediates

(2015) Andrei Ungureanu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Cooperative N-Heterocyclic Carbene/Chiral Phosphate Catalysis System for Allenolate Annulations

(2014) Anna Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid

(2014) Zijun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates

(2014) Anna Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

An Odorless, One-Pot Synthesis of Thioesters from Organic Halides, Thiourea and Benzoyl Chlorides in Water

(2013) Guo-ping Lu et al.   ADVANCED SYNTHESIS & CATALYSIS

An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis

(2013) Adel M. ElSohly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides

(2013) Jiajia Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations

(2013) Shuji Yonezawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene (NHC)-Catalyzed/Lewis Acid Mediated Conjugate Umpolung of Alkynyl Aldehydes for the Synthesis of Butenolides: A Formal [3+2] Annulation

(2013) Jing Qi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters by Using Cascade Reactions Catalyzed by an N-Heterocyclic Carbene

(2013) Bing Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

(2013) Zhenqian Fu et al.   Nature Chemistry

N-Heterocyclic Carbene-Catalyzed Stereoselective Cascade Reaction: Synthesis of Functionalized Tetrahydroquinolines

(2013) Hai-Rui Zhang et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Formal [3+2] Annulation of Alkynyl Aldehydes with Nitrosobenzenes: A Highly Regioselective Umpolung Strategy

(2013) Runfeng Han et al.   ACS Catalysis

N-Heterocyclic-Carbene-Catalyzed Asymmetric Oxidative Hetero-Diels-Alder Reactions with Simple Aliphatic Aldehydes

(2012) Xiaodan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Oxidative γ-Addition of Enals to Trifluoromethyl Ketones: Enantioselectivity Control via Lewis Acid/N-Heterocyclic Carbene Cooperative Catalysis

(2012) Junming Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles

(2012) Ding Du et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Annulation of α-Cyano-1,4-diketones with Ynals

(2012) Fedor Romanov-Michailidis et al.   ORGANIC LETTERS

Cu(OAc)2-Catalyzed Tandem Blaise/Pinner-Type Reaction for One-Pot Synthesis of Pyrimidin-4-ones

(2012) Yu Sung Chun et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

(2011) Li-Tao Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

(2011) Jing Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substituted N -aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors

(2011) Balekudru Devadas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor

(2011) Kazuyoshi Aso et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

Vilsmeier Reaction of 3-Aminopropenamides: One-Pot Synthesis of Pyrimidin-4(3H)-ones

(2011) Rui Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Expedient Synthesis ofN-Acyl Anthranilamides and β-Enamine Amides by the Rh(III)-Catalyzed Amidation of Aryl and Vinyl C–H Bonds with Isocyanates

(2011) Kevin D. Hesp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

EnantioselectiveN-Heterocyclic Carbene-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes by Redox Oxidation

(2011) Zi-Qiang Rong et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Reaction of Alkynyl Aldehydes with 1,3-Keto Esters or 1,3-Diketones

(2010) Zhi-Qiang Zhu et al.   ADVANCED SYNTHESIS & CATALYSIS

NHC-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes by Redox Activation

(2010) Suman De Sarkar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives

(2010) Feng Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Heterocyclic Carbene-Catalyzed Conjugate Additions of Alcohols

(2010) Eric M. Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CooperativeN-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates

(2010) Benoit Cardinal-David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Enantioselective Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes

(2010) Juthanat Kaeobamrung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative catalysis by carbenes and Lewis acids in a highly stereoselective route to γ-lactams

(2010) Dustin E. A. Raup et al.   Nature Chemistry

Titanium(IV) Isopropoxide Mediated Synthesis of Pyrimidin-4-ones

(2010) Joshi M. Ramanjulu et al.   ORGANIC LETTERS

Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer

(2009) William B. Parker   CHEMICAL REVIEWS

An Unexpected N-Heterocyclic Carbene-Catalyzed Annulation of Enals and Nitroso Compounds†

(2009) Limin Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene-Catalyzed Generation of α,β-Unsaturated Acyl Imidazoliums: Synthesis of Dihydropyranones by their Reaction with Enolates

(2009) Sarah J. Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A facile synthesis of pyrimidin-4-ones

(2009) Cheng Guo   TETRAHEDRON LETTERS

Asymmetric Dimerization of Disubstituted Ketenes Catalyzed by N-Heterocyclic Carbenes

(2008) Hui Lv et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Amination of Homoenolates Catalyzed byN-Heterocyclic Carbenes

(2008) Audrey Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Synthesis ofN-Phenylisoxazolidin-5-ones and a One-Pot Synthesis of β-Amino Acid Esters

(2008) Jayasree Seayad et al.   ORGANIC LETTERS