标题
Autophagy system as a potential therapeutic target for neurodegenerative diseases
作者
关键词
Autophagy, Aggregates, Neurodegenerative disease, Therapy
出版物
NEUROCHEMISTRY INTERNATIONAL
Volume -, Issue -, Pages 105308
出版商
Elsevier BV
发表日期
2022-02-16
DOI
10.1016/j.neuint.2022.105308
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular mechanisms and physiological functions of mitophagy
- (2021) Mashun Onishi et al. EMBO JOURNAL
- Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
- (2021) Mathieu Bourdenx et al. CELL
- The cell biology of Parkinson’s disease
- (2021) Nikhil Panicker et al. JOURNAL OF CELL BIOLOGY
- Parkinson's disease
- (2021) Bastiaan R Bloem et al. LANCET
- Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
- (2021) Benjamin Caballero et al. Nature Communications
- Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
- (2021) Soojin Kim et al. Nature Communications
- Tau seeds are subject to aberrant modifications resulting in distinct signatures
- (2021) Jui-Heng Tseng et al. Cell Reports
- α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
- (2021) Morgan G. Stykel et al. Cell Reports
- α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
- (2021) Aysegul Dilsizoglu Senol et al. PLOS BIOLOGY
- Autophagy in Parkinson's Disease
- (2020) Xu Hou et al. JOURNAL OF MOLECULAR BIOLOGY
- ATP13A2 deficiency disrupts lysosomal polyamine export
- (2020) Sarah van Veen et al. NATURE
- β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates
- (2020) Jung-A A. Woo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
- (2020) Natalia Moskal et al. Nature Communications
- Mechanisms governing autophagosome biogenesis
- (2020) Hitoshi Nakatogawa NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
- (2020) Insup Choi et al. Nature Communications
- Secretory Autophagy and Its Relevance in Metabolic and Degenerative Disease
- (2020) Claudio Daniel Gonzalez et al. Frontiers in Endocrinology
- Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein
- (2020) Eunna Chung et al. Science Advances
- NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation
- (2020) Cui-Zan Cai et al. Autophagy
- LRRK 2 activation controls the repair of damaged endomembranes in macrophages
- (2020) Susanne Herbst et al. EMBO JOURNAL
- Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
- (2020) Manish Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
- (2020) M. Catarina Silva et al. Nature Communications
- Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
- (2020) Tadashi Yamamuro et al. Nature Communications
- LAMP2A-mediated autophagy involved in Huntington’s disease progression
- (2020) Seung Ho Choi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress
- (2020) Stephanie Vrijsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease
- (2019) Fiona Bonello et al. HUMAN MOLECULAR GENETICS
- Suppression of autophagic activity by Rubicon is a signature of aging
- (2019) Shuhei Nakamura et al. Nature Communications
- Targetome analysis of chaperone-mediated autophagy in cancer cells
- (2019) Yuqing Hao et al. Autophagy
- Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
- (2019) Rongcan Luo et al. Autophagy
- Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)
- (2019) Philip Wing-Lok Ho et al. Autophagy
- LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10
- (2019) Fieke Wauters et al. Autophagy
- Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control
- (2019) Giansimone Perrino et al. Cell Reports
- Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
- (2019) Farah H. Siddiqi et al. Nature Communications
- The ubiquitin‐conjugating enzyme UBE 2 QL 1 coordinates lysophagy in response to endolysosomal damage
- (2019) Lisa Koerver et al. EMBO REPORTS
- Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease
- (2019) Evelina Valionyte et al. JOURNAL OF MOLECULAR BIOLOGY
- Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice
- (2019) Véronik Lachance et al. Molecular Neurodegeneration
- Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds
- (2019) Zhaoyang Li et al. NATURE
- Celastrol Inhibits Dopaminergic Neuronal Death of Parkinson’s Disease through Activating Mitophagy
- (2019) Ming-Wei Lin et al. Antioxidants
- Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice
- (2018) Zhenri Ou et al. BRAIN BEHAVIOR AND IMMUNITY
- Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
- (2018) Jimena Hebe Martinez et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The coming of age of chaperone-mediated autophagy
- (2018) Susmita Kaushik et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Lysosome trafficking and signaling in health and neurodegenerative diseases
- (2018) Pearl P.Y. Lie et al. NEUROBIOLOGY OF DISEASE
- Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease
- (2018) Diego Grassi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
- (2018) Tammy Ryan et al. Nature Communications
- LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
- (2018) Tomoya Eguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling
- (2018) Cheong-Meng Chong et al. Cell Death & Disease
- Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria
- (2018) Nadia Cummins et al. EMBO JOURNAL
- The Roles of Autophagy in Cancer
- (2018) Chul Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease
- (2018) Christy O.Y. Hung et al. Cell Reports
- Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease
- (2017) Ralph A. Nixon FASEB JOURNAL
- S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse
- (2017) Kun Han et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
- (2017) Vincenzo Sorrentino et al. NATURE
- Polyglutamine tracts regulate beclin 1-dependent autophagy
- (2017) Avraham Ashkenazi et al. NATURE
- A toxic mutant huntingtin species is resistant to selective autophagy
- (2017) Yuhua Fu et al. Nature Chemical Biology
- TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation
- (2017) Sarah Jinn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
- (2017) YouJin Lee et al. Cell Reports
- A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
- (2017) Altea Rocchi et al. PLoS Genetics
- Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases
- (2016) Marco Sardiello Annals of the New York Academy of Sciences
- The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes
- (2016) Zheng Wang et al. MOLECULAR CELL
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
- (2016) Xing Guo et al. Nature Communications
- The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
- (2016) Carla F. Bento et al. Nature Communications
- Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency
- (2016) Kavya Reddy et al. Cell Reports
- Loss of Bin1 Promotes the Propagation of Tau Pathology
- (2016) Sara Calafate et al. Cell Reports
- A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation
- (2015) Jian-Da Wang et al. Autophagy
- Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism
- (2015) Wen-Chuan Shen et al. Autophagy
- Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment
- (2015) Peng-Fei Wei et al. BIOMATERIALS
- Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement
- (2015) Lingling Hou et al. BMC NEUROSCIENCE
- Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
- (2015) Patrick Ejlerskov et al. CELL
- Neuronal Aggregates: Formation, Clearance, and Spreading
- (2015) Junghyun Lim et al. DEVELOPMENTAL CELL
- Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease
- (2015) S. Hwang et al. EMBO Molecular Medicine
- AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease
- (2015) Rafael P. Vázquez-Manrique et al. HUMAN MOLECULAR GENETICS
- shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model
- (2015) Alevtina D. Zharikov et al. JOURNAL OF CLINICAL INVESTIGATION
- PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins
- (2015) David G. McEwan et al. MOLECULAR CELL
- Huntingtin functions as a scaffold for selective macroautophagy
- (2015) Yan-Ning Rui et al. NATURE CELL BIOLOGY
- USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
- (2015) Christian N. Cunningham et al. NATURE CELL BIOLOGY
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
- (2014) V. A. Polito et al. EMBO Molecular Medicine
- Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice
- (2014) Masaru Kurosawa et al. HUMAN MOLECULAR GENETICS
- Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease
- (2014) Jong Kil Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
- (2014) Y. C. Wong et al. JOURNAL OF NEUROSCIENCE
- The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17
- (2014) Peidu Jiang et al. MOLECULAR BIOLOGY OF THE CELL
- Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway
- (2014) Jia-Qing Yan et al. MOLECULAR NEUROBIOLOGY
- The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
- (2014) Baris Bingol et al. NATURE
- Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
- (2014) R. M. Ivatt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potential function for the Huntingtin protein as a scaffold for selective autophagy
- (2014) Joseph Ochaba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52
- (2014) Chulman Jo et al. Nature Communications
- Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder
- (2014) Wei Lu et al. Nature Communications
- Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
- (2014) Eszter Zavodszky et al. Nature Communications
- BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42
- (2013) Jihoon Nah et al. Autophagy
- HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression
- (2013) Ju-Xian Song et al. Autophagy
- Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
- (2013) John W. Steele et al. Autophagy
- Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
- (2013) Ikuko Maejima et al. EMBO JOURNAL
- Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models
- (2013) M. L. Hebron et al. HUMAN MOLECULAR GENETICS
- CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease
- (2013) Alicia Semaka et al. JOURNAL OF MEDICAL GENETICS
- Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
- (2013) Tian-Fang Jiang et al. Journal of Neuroimmune Pharmacology
- Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
- (2013) Andrey S Tsvetkov et al. Nature Chemical Biology
- Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
- (2013) Jaime Anguiano et al. Nature Chemical Biology
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease
- (2013) Laura Rué et al. NEUROBIOLOGY OF DISEASE
- The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
- (2013) Marija Dulovic et al. NEUROBIOLOGY OF DISEASE
- Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
- (2013) David Freeman et al. PLoS One
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- Trafficking and Proteolytic Processing of APP
- (2013) C. Haass et al. Cold Spring Harbor Perspectives in Medicine
- The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1
- (2012) Jun-chao Wu et al. ACTA PHARMACOLOGICA SINICA
- Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
- (2012) Véronique Schaeffer et al. BRAIN
- The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes
- (2012) Eisuke Itakura et al. CELL
- TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
- (2012) Manohar Pilli et al. IMMUNITY
- Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of -Synuclein and LRRK2 in the Brain
- (2012) L. G. Friedman et al. JOURNAL OF NEUROSCIENCE
- Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
- (2012) Keiichi Inoue et al. Molecular Neurodegeneration
- Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
- (2012) Dong Liu et al. NEUROBIOLOGY OF AGING
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PGC-1 Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
- (2012) T. Tsunemi et al. Science Translational Medicine
- Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
- (2011) Raquel Sanchez-Varo et al. ACTA NEUROPATHOLOGICA
- NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
- (2011) Trond Lamark et al. CELL CYCLE
- A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
- (2011) Yuan Tian et al. FASEB JOURNAL
- Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
- (2011) Vinay Choubey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease
- (2011) H. Koga et al. JOURNAL OF NEUROSCIENCE
- Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
- (2011) Gen Matsumoto et al. MOLECULAR CELL
- APOE and Alzheimer disease: a major gene with semi-dominant inheritance
- (2011) E Genin et al. MOLECULAR PSYCHIATRY
- Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
- (2011) Alan S. L. Wong et al. NATURE CELL BIOLOGY
- Autophagy failure in Alzheimer's disease—locating the primary defect
- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
- Cell type-specific localization of optineurin in the striatal neurons of mice: implications for neuronal vulnerability in Huntington's disease
- (2011) S. Okita et al. NEUROSCIENCE
- Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
- (2011) Yuncheng Wu et al. NEUROSIGNALS
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
- (2010) Dun-Sheng Yang et al. BRAIN
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Age at onset in Huntington’s disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7
- (2010) Silke Metzger et al. HUMAN GENETICS
- AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
- (2010) Valérie Vingtdeux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Huntington's disease: from molecular pathogenesis to clinical treatment
- (2010) Christopher A Ross et al. LANCET NEUROLOGY
- The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
- (2010) Maria Filimonenko et al. MOLECULAR CELL
- Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
- (2010) Peter O Bauer et al. NATURE BIOTECHNOLOGY
- Genome-wide association studies: the key to unlocking neurodegeneration?
- (2010) Sonia Gandhi et al. NATURE NEUROSCIENCE
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease
- (2010) Giuseppe Filomeni et al. NEUROBIOLOGY OF AGING
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
- (2010) Leslie Crews et al. PLoS One
- A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
- (2010) A. S. Tsvetkov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice
- (2010) Shuqiu Zheng et al. PLoS Genetics
- Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein
- (2009) Wai Haung Yu et al. AMERICAN JOURNAL OF PATHOLOGY
- Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
- (2009) Hyunkyung Jeong et al. CELL
- IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
- (2009) Leslie Michels Thompson et al. JOURNAL OF CELL BIOLOGY
- Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
- (2009) Tohru Kitada et al. JOURNAL OF NEUROCHEMISTRY
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
- (2009) Suzana Gispert et al. PLoS One
- Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
- (2009) Q. Yang et al. SCIENCE
- Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
- (2008) Lars Bertram et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
- (2008) J. Ramesh Babu et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
- (2008) Andrea Williams et al. Nature Chemical Biology
- Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease
- (2008) Binggui Sun et al. NEURON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started