Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics

Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige

(2021) Subhashis Natua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PTBP1 is necessary for dendritic cells to regulate T cell homeostasis and antitumour immunity

(2021) Guangfeng Geng et al.   IMMUNOLOGY

Alternative splicing modulates cancer aggressiveness: role in EMT/metastasis and chemoresistance

(2021) Debanwita Roy Burman et al.   MOLECULAR BIOLOGY REPORTS

MYC‐Protein Arginine Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma

(2021) Yuhong Luo et al.   HEPATOLOGY

A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements

(2021) Lisa Fish et al.   SCIENCE

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

(2021) Sydney X. Lu et al.   CELL

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

(2021) Yichen Xu et al.   CELL

AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

(2021) Georgios I. Laliotis et al.   Nature Communications

Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity

(2021) Dirk Brehmer et al.   MOLECULAR CANCER THERAPEUTICS

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis–mediated Th17 responses and autoimmunity

(2020) Lindsay M. Webb et al.   JOURNAL OF CLINICAL INVESTIGATION

Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets

(2020) Yongbo Wang et al.   Science China-Life Sciences

Phytochemicals modulate cancer aggressiveness: A review depicting the anticancer efficacy of dietary polyphenols and their combinations

(2020) Tulika Mitra et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Roles and mechanisms of alternative splicing in cancer — implications for care

(2020) Sophie C. Bonnal et al.   Nature Reviews Clinical Oncology

Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer

(2020) Antonietta Rosella Farina et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression

(2020) Tanja Eberhart et al.   Frontiers in Cell and Developmental Biology

The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells

(2020) James E. Melnyk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeutics

(2020) Cláudia Bessa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Splicing factors: Insights into their regulatory network in alternative splicing in cancer

(2020) Jun-Xian Du et al.   CANCER LETTERS

Treating Disease at the RNA Level with Oligonucleotides

(2019) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy

(2019) Tomoki Yamano et al.   Oncotarget

hnRNPM induces translation switch under hypoxia to promote colon cancer development

(2019) Tsung-Ming Chen et al.   EBioMedicine

Alternative Splicing in Tumors — A Path to Immunogenicity?

(2019) Jill E. Slansky et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA Splicing: A New Paradigm in Host–Pathogen Interactions

(2019) Komal Chauhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer

(2019) Bo Gong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Antisense Oligonucleotides Are Coming of Age

(2019) C. Frank Bennett   Annual Review of Medicine

Alternative Splicing in Angiogenesis

(2019) Elizabeth Bowler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency

(2019) Ignacio García-Tuñón et al.   PLoS One

Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature

(2019) Paolo A Lorenzini et al.   RNA

Immunotherapy of hepatocellular carcinoma: strategies for combinatorial intervention

(2019) Mengxin Tian et al.   Science China-Life Sciences

The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy

(2019) Richard D. Paucek et al.   TRENDS IN IMMUNOLOGY

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

(2019) Andrew Fedoriw et al.   CANCER CELL

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

(2019) Polina Denichenko et al.   Nature Communications

Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase

(2019) Takahiro Hayasaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting mRNA processing as an anticancer strategy

(2019) Joana Desterro et al.   NATURE REVIEWS DRUG DISCOVERY

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

(2019) Akihide Yoshimi et al.   NATURE

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Altered RNA Processing in Cancer Pathogenesis and Therapy

(2019) Esther A. Obeng et al.   Cancer Discovery

Understanding aberrant RNA splicing to facilitate cancer diagnosis and therapy

(2019) Xuesen Dong et al.   ONCOGENE

RNA-based therapeutics for colorectal cancer: Updates and future directions

(2019) Jingwen Liu et al.   PHARMACOLOGICAL RESEARCH

Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment

(2019) Zijun Zhao et al.   Science China-Life Sciences

Splicing Dysregulation as Oncogenic Driver and Passenger Factor in Brain Tumors

(2019) Pamela Bielli et al.   Cells

Alternative splicing and cancer metastasis: prognostic and therapeutic applications

(2018) Diego M. Marzese et al.   CLINICAL & EXPERIMENTAL METASTASIS

The role of alternative splicing in cancer drug resistance

(2018) Zahava Siegfried et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

FGF9-induced ovarian cancer cell invasion involves VEGF-A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming

(2018) Rahul Bhattacharya et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice

(2018) Tomohito Doke et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

(2018) Michael Seiler et al.   NATURE MEDICINE

Alternative splicing in cancers: From aberrant regulation to new therapeutics

(2018) Xiaowei Song et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

(2018) Reyka G. Jayasinghe et al.   Cell Reports

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

(2018) Sushant Bangru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

Splicing in immune cells—mechanistic insights and emerging topics

(2017) Annalisa Schaub et al.   INTERNATIONAL IMMUNOLOGY

Novel splice-switching oligonucleotide promotesBRCA1aberrant splicing and susceptibility to PARP inhibitor action

(2017) Lindsay D. Smith et al.   INTERNATIONAL JOURNAL OF CANCER

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Alternative splicing as a regulator of development and tissue identity

(2017) Francisco E. Baralle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

(2017) Sarah J. Ross et al.   Science Translational Medicine

Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing

(2017) Jiawei Zhao et al.   Scientific Reports

Alternate splicing of transcripts shape macrophage response to Mycobacterium tuberculosis infection

(2017) Haroon Kalam et al.   PLoS Pathogens

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

(2017) Anzhalika Sidarovich et al.   eLife

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

(2017) Felicia Fei-Lei Chung et al.   Scientific Reports

Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells

(2017) Jian Han et al.   Scientific Reports

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins

(2016) Mahbod Sahebi et al.   GENE

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

(2016) Qing Tang et al.   GENES & DEVELOPMENT

A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

(2016) Dror Hollander et al.   GENOME RESEARCH

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

(2016) Endre Sebestyén et al.   GENOME RESEARCH

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function

(2016) Chioniso P. Masamha et al.   RNA

Splicing-factor alterations in cancers

(2016) Olga Anczuków et al.   RNA

Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

(2016) Isabel Meininger et al.   Nature Communications

Alternative splicing within the Wnt signaling pathway: role in cancer development

(2016) B. Sumithra et al.   CELLULAR ONCOLOGY

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

(2016) Dennis Liang Fei et al.   PLoS Genetics

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

(2016) Federico A. De Maio et al.   PLoS Pathogens

RNA-binding protein hnRNPLL as a critical regulator of lymphocyte homeostasis and differentiation

(2016) Xing Chang   Wiley Interdisciplinary Reviews-RNA

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

(2015) Eunhee Kim et al.   CANCER CELL

hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies

(2015) Miguel Gallardo et al.   CANCER CELL

A Chemical Genetics Approach for the Functional Assessment of Novel Cancer Genes

(2015) Q. Zhou et al.   CANCER RESEARCH

The Natural ProductN-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes

(2015) Kerstin A. Effenberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia

(2015) Egle Jakubauskiene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth

(2015) Michael Dewaele et al.   JOURNAL OF CLINICAL INVESTIGATION

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

(2015) M Larrayoz et al.   LEUKEMIA

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

Intron retention is a widespread mechanism of tumor-suppressor inactivation

(2015) Hyunchul Jung et al.   NATURE GENETICS

The RNA-binding protein HuR is essential for the B cell antibody response

(2015) Manuel D Diaz-Muñoz et al.   NATURE IMMUNOLOGY

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

(2015) S Calabretta et al.   ONCOGENE

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

Pro-apoptotic effects of splice-switching oligonucleotides targeting Bcl-x pre-mRNA in human glioma cell lines

(2015) ZHAOHUI LI et al.   ONCOLOGY REPORTS

Disease-associated mutation inSRSF2misregulates splicing by altering RNA-binding affinities

(2015) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

(2015) David Hong et al.   Science Translational Medicine

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update

(2015) Sheng Yan   WORLD JOURNAL OF GASTROENTEROLOGY

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome

(2015) Vikas Madan et al.   Nature Communications

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

(2015) Rachel B. Darman et al.   Cell Reports

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma

(2014) M V Gammons et al.   BRITISH JOURNAL OF CANCER

The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression

(2014) Yang Wang et al.   CANCER CELL

U2AF1mutations alter splice site recognition in hematological malignancies

(2014) Janine O. Ilagan et al.   GENOME RESEARCH

CD20 alternative splicing isoform generates immunogenic CD4 helper T epitopes

(2014) Charline Vauchy et al.   INTERNATIONAL JOURNAL OF CANCER

Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy

(2014) M. A. Lanaspa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer

(2014) Ioannis Sanidas et al.   MOLECULAR CELL

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

(2014) Mads A Jensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

(2014) Julian Swierczynski   WORLD JOURNAL OF GASTROENTEROLOGY

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells

(2014) Yang Gao et al.   Scientific Reports

Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

(2013) Chandraiah Lagisetti et al.   ACS Chemical Biology

Dynamic Integration of Splicing within Gene Regulatory Pathways

(2013) Ulrich Braunschweig et al.   CELL

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

(2013) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity

(2013) Lesly De Arras et al.   GENETICS

The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells

(2013) Rong Jia et al.   IMMUNOLOGY LETTERS

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

(2013) D. S. Hong et al.   INVESTIGATIONAL NEW DRUGS

Regulation of alternative splicing by local histone modifications: potential roles for RNA-guided mechanisms

(2013) H.-L. Zhou et al.   NUCLEIC ACIDS RESEARCH

Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer

(2013) Xinyu Wu et al.   PLoS One

Differential splicing across immune system lineages

(2013) A. Ergun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misregulation of Pre-mRNA Alternative Splicing in Cancer

(2013) J. Zhang et al.   Cancer Discovery

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

(2013) Lesly De Arras et al.   PLoS Genetics

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

(2012) Rong Jia et al.   International Journal of Biological Sciences

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Argonaute proteins couple chromatin silencing to alternative splicing

(2012) Maya Ameyar-Zazoua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing

(2012) Marco Preußner et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

(2012) A. Cassago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PKM2: A gatekeeper between growth and survival

(2011) Isaac Harris et al.   CELL RESEARCH

Asyn-anticonformational difference allows SRSF2 to recognize guanines and cytosines equally well

(2011) Gerrit M Daubner et al.   EMBO JOURNAL

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner

(2011) H.-L. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis of spliceosomal small nuclear ribonucleoproteins

(2011) Utz Fischer et al.   Wiley Interdisciplinary Reviews-RNA

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA

(2010) M. Chen et al.   CANCER RESEARCH

Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation

(2010) Karen E. Matsukuma et al.   HUMAN PATHOLOGY

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

(2010) Gabriel A. Roybal et al.   NUCLEIC ACIDS RESEARCH

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

The anti-angiogenic isoforms of VEGF in health and disease

(2009) Yan Qiu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

(2009) Christine P. Diggle et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Biased Chromatin Signatures around Polyadenylation Sites and Exons

(2009) Noah Spies et al.   MOLECULAR CELL

Differential chromatin marking of introns and expressed exons by H3K36me3

(2009) Paulina Kolasinska-Zwierz et al.   NATURE GENETICS

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

(2008) Yimin Hua et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mammalian Long-Chain Acyl-CoA Synthetases

(2008) Eric Soupene et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Alternative splicing in the NF-κB signaling pathway

(2008) Joshua R. Leeman et al.   GENE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

A role for ubiquitin in the spliceosome assembly pathway

(2008) Priya Bellare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY