RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

Structure-Dependent Binding of hnRNPA1 to Telomere RNA

(2017) Xiao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The CD44s splice isoform is a central mediator for invadopodia activity

(2016) Pu Zhao et al.   JOURNAL OF CELL SCIENCE

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

(2016) Chun Kit Kwok et al.   NATURE METHODS

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

(2016) Erin G Conlon et al.   eLife

Learning the Sequence Determinants of Alternative Splicing from Millions of Random Sequences

(2015) Alexander B. Rosenberg et al.   CELL

Alternative CD44 splicing identifies epithelial prostate cancer cells from the mesenchymal counterparts

(2015) James R. Hernandez et al.   MEDICAL ONCOLOGY

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

Building Robust Transcriptomes with Master Splicing Factors

(2014) Mohini Jangi et al.   CELL

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

(2014) Y. Xu et al.   GENES & DEVELOPMENT

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

Identification and characterization of RNA guanine-quadruplex binding proteins

(2014) Annekathrin von Hacht et al.   NUCLEIC ACIDS RESEARCH

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Helicases DDX5 and DDX17 Dynamically Orchestrate Transcription, miRNA, and Splicing Programs in Cell Differentiation

(2014) Etienne Dardenne et al.   Cell Reports

TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)nRepeat of theC9orf72Gene and Blocks Interaction of RNA-binding Proteins

(2013) Bita Zamiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biophysical characterization of G-quadruplex forming FMR1 mRNA and of its interactions with different fragile X mental retardation protein isoforms

(2013) A. C. Blice-Baum et al.   RNA

Misregulation of Pre-mRNA Alternative Splicing in Cancer

(2013) J. Zhang et al.   Cancer Discovery

Alternative RNA splicing and cancer

(2013) Sali Liu et al.   Wiley Interdisciplinary Reviews-RNA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

RNA G-Quadruplexes: G-quadruplexes with “U” Turns

(2012) Tani Agarwal et al.   CURRENT PHARMACEUTICAL DESIGN

Snail Represses the Splicing Regulator Epithelial Splicing Regulatory Protein 1 to Promote Epithelial-Mesenchymal Transition

(2012) Lauren M. Reinke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circular dichroism and guanine quadruplexes

(2012) Michaela Vorlíčková et al.   METHODS

The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells

(2012) Mark J. Morris et al.   NUCLEIC ACIDS RESEARCH

The high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA

(2012) Brighton Samatanga et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Translational repression of cyclin D3 by a stable G-quadruplex in its 5′ UTR: implications for cell cycle regulation

(2012) Heng-You Weng et al.   RNA Biology

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

G-quadruplexes in RNA biology

(2012) Stefania Millevoi et al.   Wiley Interdisciplinary Reviews-RNA

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage

(2011) A. Decorsiere et al.   GENES & DEVELOPMENT

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

(2011) Rhonda L. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

Research Progress of RNA Quadruplex

(2011) Xiaohui Ji et al.   Nucleic Acid Therapeutics

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

(2010) Virginie Marcel et al.   CARCINOGENESIS

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Analysis and design of RNA sequencing experiments for identifying isoform regulation

(2010) Yarden Katz et al.   NATURE METHODS

Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs

(2010) Cyril Dominguez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU

(2010) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

Shedding Light on the Interaction between TMPyP4 and Human Telomeric Quadruplexes

(2009) Luigi Martino et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Splice site strength–dependent activity and genetic buffering by poly-G runs

(2009) Xinshu Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA

(2009) N. Ofer et al.   NUCLEIC ACIDS RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

(2008) M. Sultan et al.   SCIENCE

Formation and temperature stability of G-quadruplex structures studied by electronic and vibrational circular dichroism spectroscopy combined with ab initio calculations

(2007) Jakub Nový et al.   BIOPOLYMERS