Alternative splicing within the Wnt signaling pathway: role in cancer development

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling

(2014) Andreas Herbst et al.   BMC GENOMICS

Wnt signaling pathway: Implications for therapy in lung cancer and bone metastasis

(2014) Yongming Xi et al.   CANCER LETTERS

Casein Kinase 1 Epsilon Expression Predicts Poorer Prognosis in Low T-Stage Oral Cancer Patients

(2014) Shu-Hui Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

(2014) Birgit Schittek et al.   Molecular Cancer

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition

(2014) Nate P. Hoverter et al.   NUCLEIC ACIDS RESEARCH

A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events

(2014) Angela N. Brooks et al.   PLoS One

The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer

(2014) Jacqueline Stockley et al.   RNA Biology

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells

(2014) V. Goncalves et al.   RNA

New insights into the regulation of Axin function in canonical Wnt signaling pathway

(2014) Xiaomin Song et al.   Protein & Cell

ROR1, an embryonic protein with an emerging role in cancer biology

(2014) Nicholas Borcherding et al.   Protein & Cell

Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer

(2013) Dawn T Bravo et al.   BMC CANCER

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

(2013) J P Dijksterhuis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

The Tyrosine Kinase Receptor ROR1 Is Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) Cells

(2013) Mohammad Hojjat-Farsangi et al.   PLoS One

WNT5A Encodes Two Isoforms with Distinct Functions in Cancers

(2013) Matthieu Bauer et al.   PLoS One

The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction

(2013) J. Green et al.   Cold Spring Harbor Perspectives in Biology

An Emerging Strategy for Cancer Treatment Targeting Aberrant Glycogen Synthase Kinase 3β

(2012) Katsuyoshi Miyashita et al.   Anti-Cancer Agents in Medicinal Chemistry

The balance between two isoforms of LEF-1 regulates colon carcinoma growth

(2012) Shu-Hong Wang et al.   BMC GASTROENTEROLOGY

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Dominant-negative isoforms of Tcf/Lef proteins in development and disease

(2012) Tomas Vacik et al.   CELL CYCLE

Wnt, Osteosarcoma, and Future Therapy

(2012) B. H. Hoang   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells

(2012) A H Daneshmanesh et al.   LEUKEMIA

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression

(2012) Britta Wallmen et al.   NUCLEIC ACIDS RESEARCH

A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation

(2012) Shree Harsha Vijaya Chandra et al.   PLoS One

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

(2012) Hema Dave et al.   PLoS One

Wnt Signaling

(2012) R. Nusse   Cold Spring Harbor Perspectives in Biology

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation

(2011) X. Jin et al.   CANCER RESEARCH

Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells

(2011) Orkhontuya Tsedensodnom et al.   EXPERIMENTAL CELL RESEARCH

The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

(2011) Taj D. King et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

β-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance

(2011) Tobias Sinnberg et al.   PLoS One

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

(2011) M. L. Angus-Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DEGRADE, MOVE, REGROUP: signaling control of splicing proteins

(2011) Florian Heyd et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genome-wide approaches for cancer gene discovery

(2011) Paul M. Lizardi et al.   TRENDS IN BIOTECHNOLOGY

Diversity of axin in signaling pathways and its relation to colorectal cancer

(2010) Nighat Parveen et al.   MEDICAL ONCOLOGY

Alternative Splicing of SLC39A14 in Colorectal Cancer is Regulated by the Wnt Pathway

(2010) Kasper Thorsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

(2010) Andreas Weise et al.   NUCLEIC ACIDS RESEARCH

International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors

(2010) G. Schulte   PHARMACOLOGICAL REVIEWS

CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity

(2010) So Young Kim et al.   PLoS One

Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: Identification of a 7.2-kb microdeletion using oligonucleotide tiling microarray

(2009) Satoshi Narumi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

(2009) Laura Arce et al.   BMC CANCER

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Large intron 14 rearrangement in APC results in splice defect and attenuated FAP

(2009) Thérèse M. F. Tuohy et al.   HUMAN GENETICS

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

(2009) Vânia Gonçalves et al.   HUMAN MOLECULAR GENETICS

Analysis of Rare APC Variants at the mRNA Level

(2009) Astrid Kaufmann et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Internally Truncated LRP5 Receptor Presents a Therapeutic Target in Breast Cancer

(2009) Peyman Björklund et al.   PLoS One

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

Wnt signaling inside the nucleus

(2008) Miki Shitashige et al.   CANCER SCIENCE

Unique Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Human B-Cell Chronic Lymphocytic Leukemia

(2008) S. Baskar et al.   CLINICAL CANCER RESEARCH

WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome

(2008) P. D. Da Forno et al.   CLINICAL CANCER RESEARCH

Alternative Splicing and Tumor Progression

(2008) Claudia Ghigna et al.   CURRENT GENOMICS

The Role of LEF/TCF Factors in Neoplastic Transformation

(2008) Mohamed El-Tanani et al.   CURRENT MOLECULAR MEDICINE

Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo

(2008) C Brockschmidt et al.   GUT

A missense mutation in the APC tumor suppressor gene disrupts an ASF/SF2 splicing enhancer motif and causes pathogenic skipping of exon 14

(2008) Vânia Gonçalves et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The  -catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression

(2008) V. Goncalves et al.   RNA

Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression

(2008) Peng-Chieh Chen et al.   PLoS Genetics

The Groucho/TLE/Grg family of transcriptional co-repressors

(2008) Barbara H Jennings et al.   GENOME BIOLOGY