New insights into the role of autophagy in retinal and eye diseases

Retinal Inflammation, Cell Death and Inherited Retinal Dystrophies

(2021) Lorena Olivares-González et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy activation and photoreceptor survival in retinal detachment

(2021) Jianhui Xiao et al.   EXPERIMENTAL EYE RESEARCH

Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy

(2021) Thaddaeus Mutugi Nthiga et al.   JOURNAL OF CELL BIOLOGY

The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration

(2021) Elsayed Metwally et al.   TRENDS IN NEUROSCIENCES

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

(2021) James R. Tribble et al.   Redox Biology

Acute ischemic optic nerve disease: Pathophysiology, clinical features and management

(2020) E. Augstburger et al.   JOURNAL FRANCAIS D OPHTALMOLOGIE

Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes

(2020) Cun-Jin Su et al.   Neuroscience Bulletin

Dysregulated metabolic pathways in age-related macular degeneration

(2020) Meng Zhang et al.   Scientific Reports

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Light‐responsive microRNA miR‐211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance

(2020) Federica Naso et al.   EMBO JOURNAL

The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models

(2020) Ines Rosignol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

(2020) Iswariyaraja Sridevi Gurubaran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina

(2020) Xiaoping Qi et al.   Cells

MTOR‐initiated metabolic switch and degeneration in the retinal pigment epithelium

(2020) Young‐Mi Go et al.   FASEB JOURNAL

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

(2020) Samuel Abokyi et al.   Oxidative Medicine and Cellular Longevity

Retinal energy metabolism in health and glaucoma

(2020) Robert J. Casson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies

(2020) Kamil Kruczek et al.   STEM CELLS

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

(2020) Marta Zaninello et al.   Nature Communications

Age related retinal Ganglion cell susceptibility in context of autophagy deficiency

(2020) Katharina Bell et al.   Cell Death Discovery

Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury

(2020) Jing-Yao Song et al.   Aging-US

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Mitochondrial Fusion: The Machineries In and Out

(2020) Song Gao et al.   TRENDS IN CELL BIOLOGY

Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling

(2020) Rui Zhang et al.   Cell Death & Disease

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

(2020) Husvinee Sundaramurthi et al.   Frontiers in Cell and Developmental Biology

Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

(2020) Passley Hargrove-Grimes et al.   PLoS Genetics

Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma

(2020) April Nettesheim et al.   Journal of Clinical Medicine

Progress in developing rodent models of age-related macular degeneration (AMD)

(2020) Sudha Priya Soundara Pandi et al.   EXPERIMENTAL EYE RESEARCH

Loss of MPC1 reprograms retinal metabolism to impair visual function

(2019) Allison Grenell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Inhibited Photoreceptor Necroptosis and Protected the Retina by Activation of Autophagy in Experimental Retinal Detachment

(2019) Jie Ding et al.   CURRENT EYE RESEARCH

A comparative map of macroautophagy and mitophagy in the vertebrate eye

(2019) Thomas G. McWilliams et al.   Autophagy

Autophagy in Xenopus laevis rod photoreceptors is independently regulated by phototransduction and misfolded RHOP23H

(2019) Runxia H Wen et al.   Autophagy

Autophagy in Neurons

(2019) Andrea K.H. Stavoe et al.   Annual Review of Cell and Developmental Biology

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Critical review: Typical and atypical optic neuritis

(2019) Anne Abel et al.   SURVEY OF OPHTHALMOLOGY

Mendelian genes in primary open angle glaucoma

(2019) Nathan C. Sears et al.   EXPERIMENTAL EYE RESEARCH

Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis

(2019) Jeany Q Li et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Update on the genetics of primary open-angle glaucoma

(2019) Hannah Youngblood et al.   EXPERIMENTAL EYE RESEARCH

Clinical implications of recent advances in primary open-angle glaucoma genetics

(2019) Hélène Choquet et al.   EYE

Selective Autophagy Receptors in Neuronal Health and Disease

(2019) Owen Conway et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

(2019) Shoji Notomi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATG conjugation systems in autophagy

(2019) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

Inhibiting autophagy reduces retinal degeneration caused by protein misfolding

(2018) Jingyu Yao et al.   Autophagy

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Leber’s hereditary optic neuropathy (LHON)-associated ND5 12338T > C mutation altered the assembly and function of complex I, apoptosis and mitophagy

(2018) Juanjuan Zhang et al.   HUMAN MOLECULAR GENETICS

Sodium Iodate Disrupted the Mitochondrial-Lysosomal Axis in Cultured Retinal Pigment Epithelial Cells

(2018) Ying-Cheng Lin et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells

(2018) George Inana et al.   Journal of Translational Medicine

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration

(2018) Monika Fleckenstein et al.   OPHTHALMOLOGY

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2018) Anthea Di Rita et al.   Frontiers in Cellular Neuroscience

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

(2018) Ghanshyam Swarup et al.   Frontiers in Immunology

Too sweet: Problems of protein glycation in the eye

(2018) Eloy Bejarano et al.   EXPERIMENTAL EYE RESEARCH

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

Mitophagy activation repairs Leber’s hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survival

(2018) Lokendra Kumar Sharma et al.   HUMAN MOLECULAR GENETICS

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

(2018) Arthur A. Bergen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

(2018) Szabolcs Felszeghy et al.   Redox Biology

Autophagy and mechanotransduction in outflow pathway cells

(2017) Joshua Hirt et al.   EXPERIMENTAL EYE RESEARCH

Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell

(2017) Lei Lei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy

(2017) Mariame Selma Kane et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

(2017) Sayantan Datta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

(2017) Nady Golestaneh et al.   Cell Death & Disease

Standard Assays for the Study of Autophagy in the Ex Vivo Retina

(2017) et al.   Cells

Lysosomal cell death mechanisms in aging

(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation

(2016) Daisuke Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Survival or death: a dual role for autophagy in stress-induced pericyte loss in diabetic retinopathy

(2016) Dongxu Fu et al.   DIABETOLOGIA

Autophagy in light-induced retinal damage

(2016) Yu Chen et al.   EXPERIMENTAL EYE RESEARCH

Why autophagy is good for retinal ganglion cells?

(2016) P Boya   EYE

Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration

(2016) Fuxiang Ye et al.   FREE RADICAL BIOLOGY AND MEDICINE

OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy

(2016) Manon F Moulis et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

(2016) Chunyan Liao et al.   NEUROLOGY

Autophagy in the eye: Development, degeneration, and aging

(2016) Patricia Boya et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mitophagy in mitosis: More than a myth

(2015) Lorena Esteban-Martínez et al.   Autophagy

Deletion of autophagy inducerRB1CC1results in degeneration of the retinal pigment epithelium

(2015) Jingyu Yao et al.   Autophagy

Autophagy supports color vision

(2015) Zhenqing Zhou et al.   Autophagy

Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress

(2015) Huanqi Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Erratum: AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2015) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Autophagy supports survival and phototransduction protein levels in rod photoreceptors

(2015) Z Zhou et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment

(2015) Shameka J. Shelby et al.   EXPERIMENTAL EYE RESEARCH

Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium

(2015) Lindsay Perusek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Autophagic flux determination in vivo and ex vivo

(2015) Lorena Esteban-Martínez et al.   METHODS

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Toxic optic neuropathies: an updated review

(2014) Andrzej Grzybowski et al.   ACTA OPHTHALMOLOGICA

Utilizing flow cytometry to monitor autophagy in living mammalian cells

(2014) Elena Shvets et al.   Autophagy

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells

(2014) Niina Piippo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium

(2014) Lei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors

(2014) Olga S. Sizova et al.   CELLULAR SIGNALLING

Cancer-like metabolism of the mammalian retina

(2014) Soo Khai Ng et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Retinal cell death and current strategies in retinal neuroprotection

(2014) Nicholas D. Chinskey et al.   CURRENT OPINION IN OPHTHALMOLOGY

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

The Complex Role of Neuroinflammation in Glaucoma

(2014) I. Soto et al.   Cold Spring Harbor Perspectives in Medicine

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Noncanonical autophagy: one small step for LC3, one giant leap for immunity

(2013) Payal Mehta et al.   CURRENT OPINION IN IMMUNOLOGY

Retinal neurogenesis

(2013) L. Centanin et al.   DEVELOPMENT

The cell stress machinery and retinal degeneration

(2013) Dimitra Athanasiou et al.   FEBS LETTERS

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation

(2013) Ying Dai et al.   HUMAN MOLECULAR GENETICS

Deletion of Autophagy-related 5 (Atg5) andPik3c3Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation

(2013) Hideaki Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Protects the Retina from Light-induced Degeneration

(2013) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics

(2013) Marcel V Alavi et al.   Molecular Neurodegeneration

Recycling in sight

(2013) Patricia Boya et al.   NATURE

Photoreceptor cell death and rescue in retinal detachment and degenerations

(2013) Yusuke Murakami et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration

(2013) Y Kitaoka et al.   Cell Death & Disease

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

(2012) Patricia Vázquez et al.   Autophagy

An explanation for the Warburg effect in the adult mammalian retina

(2012) Robert J Casson et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

Dominant optic atrophy

(2012) Guy Lenaers et al.   Orphanet Journal of Rare Diseases

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

LHON: Mitochondrial Mutations and More

(2011) E. Kirches   CURRENT GENOMICS

Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease

(2011) H. Koga et al.   JOURNAL OF NEUROSCIENCE

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

Effect of neurotrophin-4 on endoplasmic reticulum stress-related neuronal apoptosis in diabetic and high glucose exposed rat retinas

(2011) Toshiyuki Oshitari et al.   NEUROSCIENCE LETTERS

Age-Related Retinopathy in NRF2-Deficient Mice

(2011) Zhenyang Zhao et al.   PLoS One

The bisretinoids of retinal pigment epithelium

(2011) Janet R. Sparrow et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

(2011) R Russo et al.   Cell Death & Disease

Autophagy-Dependent Rhodopsin Degradation Prevents Retinal Degeneration in Drosophila

(2010) R. Midorikawa et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is not universally required for phosphatidyl-serine exposure and apoptotic cell engulfment during neural development

(2009) María A. Mellén et al.   Autophagy

TOR-mediated autophagy regulates cell death inDrosophilaneurodegenerative disease

(2009) Tao Wang et al.   JOURNAL OF CELL BIOLOGY

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration

(2009) Ai Ling Wang et al.   PLoS One

Retinal light damage: Mechanisms and protection

(2009) Daniel T. Organisciak et al.   PROGRESS IN RETINAL AND EYE RESEARCH

How autophagy is related to programmed cell death during the development of the nervous system

(2008) Patricia Boya et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium

(2008) M A Mellén et al.   CELL DEATH AND DIFFERENTIATION

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

(2008) Tuomas Ryhänen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE