Article
Ophthalmology
Alexander Kolesnikov, Jennings Luu, Hui Jin, Krzysztof Palczewski, Vladimir J. Kefalov
Summary: This study examined the effects of PP2A deficiency in the absence of GRK1 or Arr1 on rod photoreceptor viability. The results showed that while PP2A is not necessary for the survival of rods, its deletion accelerates the degeneration caused by the absence of either GRK1 or Arr1.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Neurosciences
Meng- Zhao, Houting Lv, Na Yang, Guang-Hua Peng
Summary: The study investigated the mechanism of retinal photoreceptor degeneration by establishing a stable retinitis pigmentosa (RP) model. It was found that activation of mTOR may be associated with RP, and the use of mTOR inhibitor rapamycin improved retinal function and photoreceptor thickness and morphology, possibly by activating autophagy to protect retinal photoreceptors.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hao-Yu Tsai, Henkie Isahwan Ahmad Mulyadi Lai, Zhang-Yuan Chen, Tai-Chi Lin, Winnie Khor, Wen-Chuan Kuo, Jia-Pu Syu, Ping-Hsing Tsai, Yi-Ping Yang, Yueh Chien, Shih-Jen Chen, De-Kuang Hwang, Shih-Hwa Chiou, Shih-Jie Chou
Summary: Inhibition of DUSP6 activity promotes autophagy flux and restores retinal damage caused by oxidative stress. DUSP6 inhibitor shows potential therapeutic effects in treating retinal degeneration.
Article
Biochemistry & Molecular Biology
Merry Gunawan, Choonbing Low, Kurt Neo, Siawey Yeo, Candice Ho, Veluchamy A. Barathi, Anita Sookyee Chan, Najam A. Sharif, Masaaki Kageyama
Summary: This study showed that autophagy may not be an effective intrinsic protective mechanism for retinal damage induced by insults, including impaired proteasomal activity. Activation of autophagy beyond normal levels is required to alleviate the cytotoxic effect of proteasomal inhibition, suggesting the need for further research on the precise roles of different forms of autophagy in rescuing retinal neurons under various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Min Ji Yoon, Boyoon Choi, Eun Jin Kim, Jiyeon Ohk, Chansik Yang, Yeon-Gil Choi, Jinyoung Lee, Chanhee Kang, Hyun Kyu Song, Yoon Ki Kim, Jae-Sung Woo, Yongcheol Cho, Eui-Ju Choi, Hosung Jung, Chungho Kim
Summary: The study reveals that UXT functions as an autophagy adaptor for p62-dependent aggrephagy, delaying motor neuron degeneration in a Xenopus model. Additionally, the cooperative relationship between molecular chaperones and the aggrephagy machinery is demonstrated for efficient removal of misfolded protein aggregates.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Ning Zhao, Ning Li, Tao Wang
Summary: Chronic endoplasmic reticulum (ER) stress is the main cause of degenerative diseases such as autosomal dominant retinitis pigmentosa. Through genetic screening, it was found that PERK signaling plays a crucial role in maintaining the balance of mutant and wild-type rhodopsin, preventing autophagy and suppressing retinal degeneration. These findings suggest that promoting PERK activity could be a potential treatment for ER stress-related neuropathies.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Charles F. Zorumski, Yukitoshi Izumi
Summary: In this study, it was found that both AlloP and its enantiomer ent-AlloP have neuroprotective effects in ex vivo and in vivo rat models of ocular hypertension, with ent-AlloP being more effective in activating autophagy while having little effect on GABA receptors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Paul-Alexandre Dechelle-Marquet, Xavier Guillonneau, Florian Sennlaub, Cecile Delarasse
Summary: This article discusses the potential involvement of P2X7 in the development of AMD and uveitis, as a sensor for high concentrations of released ATP, and its participation in various physiological and pathological processes.
Review
Neurosciences
Fangyuan Zhen, Tongdan Zou, Ting Wang, Yongwei Zhou, Shuqian Dong, Houbin Zhang
Summary: Rhodopsin is a light-sensitive receptor that initiates the phototransduction cascade. Mutations in the rhodopsin-encoding gene are the leading cause of retinitis pigmentosa. The high allelic heterogeneity suggests complex pathogenic mechanisms related to protein misfolding and dysfunction.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Guang-Ping Zou, Tao Wang, Jin-Xing Xiao, Xiao-Yu Wang, Li-Ping Jiang, Fang-Fang Tou, Zhi-Ping Chen, Xin-Hui Qu, Xiao-Jian Han
Summary: Age-related macular degeneration, a common cause of blindness in the elderly, is primarily attributed to oxidative stress and dysregulated autophagy in retinal pigment epithelium cells. Lactate has been found to act as a signaling molecule that protects against oxidative stress. This study aimed to investigate the protective effect of lactate against oxidative stress-induced retinal degeneration. The results showed that lactate alleviated oxidative stress-induced cell death and retinal degeneration by activating autophagy and preserving mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Villarejo-Zori, Juan Ignacio Jimenez-Loygorri, Juan Zapata-Munoz, Katharina Bell, Patricia Boya
Summary: Autophagy is a crucial quality control mechanism in cells, particularly in non-dividing cells like neurons. The retina, a light-sensitive tissue in the eye, is exposed to various stressors and requires autophagy for maintaining homeostasis. Understanding the role of autophagy in retinal function and eye diseases may lead to potential therapeutic strategies.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Cell Biology
Xiaoyin Ma, Shuxian Han, Youjia Liu, Yu Chen, Pingping Li, Xiaoyan Liu, Lifu Chang, Ying-ao Chen, Feng Chen, Qiang Hou, Ling Hou
Summary: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) is involved in the pathogenesis of proliferative vitreoretinopathy (PVR). In this study, downregulation of death-associated protein-like 1 (DAPL1) expression in PVR membranes was observed, and DAPL1 deficiency promoted EMT in RPE cells in mice. Overexpression of DAPL1 inhibited EMT in both physiological and retinal-detachment states, and attenuated the severity of experimental PVR in a rabbit model. Mechanistically, DAPL1 promoted P21 phosphorylation and stabilization through NF kappa B (RelA) in RPE cells, and knockdown of P21 partially neutralized the inhibitory effect of DAPL1 on EMT and enhanced the severity of experimental PVR.
CELL DEATH & DISEASE
(2023)
Editorial Material
Neurosciences
Roberto Pinelli, Michela Ferrucci, Francesca Biagioni, Violet Bumah, Elena Scaffidi, Stefano Puglisi-Allegra, Francesco Fornai
Summary: Defective autophagy in the RPE is involved in AMD, and curcumin can protect RPE cells from damage induced by the autophagy inhibitor 3-MA by activating autophagy.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Yan Wang, Vanessa Hull, Sarah Sternbach, Brad Popovich, Travis Burns, Jennifer McDonough, Fuzheng Guo, David Pleasure
Summary: Canavan disease is a rare genetic disorder caused by ASPA mutations, leading to excessive accumulation of NAA in the brain and abnormal formation of intramyelinic cells. The sodium-dependent dicarboxylate transporter NaDC3, encoded by SLC13A3, plays a crucial role in the pathogenesis of Canavan disease.
ANNALS OF NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Md Entaz Bahar, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Trang Minh Pham, Omar Elashkar, Kazi-Marjahan Akter, Dong-Hee Kim, Jinsung Yang, Deok Ryong Kim
Summary: Intervertebral disc degeneration (IVDD) is a common cause of low back pain, and autophagy plays an important role in its pathogenesis. While some studies have shown that autophagy can protect against and delay disc degeneration, further research is needed to determine its role in intervertebral cell integrity and establish it as a therapeutic target for IVDD.
Article
Genetics & Heredity
Takashi Okumura, Takeshi Sasamura, Momoko Inatomi, Shunya Hozumi, Mitsutoshi Nakamura, Ryo Hatori, Kiichiro Taniguchi, Naotaka Nakazawa, Emiko Suzuki, Reo Maeda, Tomoko Yamakawa, Kenji Matsuno
Article
Neurosciences
Atsushi Sugie, Satoko Hakeda-Suzuki, Emiko Suzuki, Marion Silies, Mai Shimozono, Christoph Moehl, Takashi Suzuki, Gaia Tavosanis
Article
Cell Biology
Shinji Ihara, Sohei Nakayama, Yoshiko Murakami, Emiko Suzuki, Masayo Asakawa, Taroh Kinoshita, Hitoshi Sawa
JOURNAL OF CELL SCIENCE
(2017)
Article
Neurosciences
Minoru Nakayama, Emiko Suzuki, Shin-ichi Tsunoda, Chihiro Hama
JOURNAL OF NEUROSCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Yoichiro Tamori, Emiko Suzuki, Wu-Min Deng
Article
Cell Biology
Miki Yamamoto-Hino, Eri Katsumata, Emiko Suzuki, Yusuke Maeda, Taroh Kinoshita, Satoshi Goto
JOURNAL OF CELL SCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Munal Babu Kandel, Saki Yamamoto, Ryosuke Midorikawa, Jyoji Morise, Yoshihiko Wakazono, Shogo Oka, Kogo Takamiya
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Rieko Ajima, Emiko Suzuki, Yumiko Saga
Article
Biochemistry & Molecular Biology
Wen-Ting Yang, Yu-Chiao Li, Chiao-Ming Lin, Wei-Chun Tang, Bi-Chang Chen, Emiko Suzuki, Jui-Chou Hsu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Ryosuke Midorikawa, Daisuke Takakura, Jyoji Morise, Yoshihiko Wakazono, Nana Kawasaki, Shogo Oka, Kogo Takamiya
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Biology
Eri Arimoto, Yutaro Kawashima, Taein Choi, Mami Unagami, Shintaro Akiyama, Mizuki Tomizawa, Hiroyuki Yano, Emiko Suzuki, Masaki Sone
Article
Biochemistry & Molecular Biology
Jyoji Morise, Saki Yamamoto, Ryosuke Midorikawa, Kogo Takamiya, Motohiro Nonaka, Hiromu Takematsu, Shogo Oka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Kohei Kawaguchi, Miki Yamamoto-Hino, Nina Matsuyama, Emiko Suzuki, Satoshi Goto
Summary: The study reveals that glycosylphosphatidylinositol-anchored proteins are attached by GPI transamidase, with subunits showing different localizations in cells, such as PIGK mainly in the endoplasmic reticulum and the other four subunits in the nuclear envelope and ER. The localization ratio of PIGS varies between cell types and developmental stages, indicating potential diverse functions of these subunits in GPI attachment.
Article
Multidisciplinary Sciences
Mikiko Oka, Emiko Suzuki, Akiko Asada, Taro Saito, Koichi M. Iijima, Kanae Ando
Summary: Brain neurons play a significant role in organismal aging, with decreased ATP concentration, glucose content, and mitochondrial quality found in aged flies. By increasing neuronal glucose uptake, ATP levels can be maintained, locomotor deficits can be suppressed, and life span can be extended, especially during dietary restriction.
Article
Cell Biology
Michiko Sekiya, Akiko Maruko-Otake, Stephen Hearn, Yasufumi Sakakibara, Naoki Fujisaki, Emiko Suzuki, Kanae Ando, Koichi M. Iijima
DEVELOPMENTAL CELL
(2017)