Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

(2018) Ruby Macdonald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy

(2018) Shanjie Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Insulin resistance causes inflammation in adipose tissue

(2018) Mitsugu Shimobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphodiesterase 4 and 7 inhibitors produce protective effects against high glucose-induced neurotoxicity in PC12 cells via modulation of the oxidative stress, apoptosis and inflammation pathways

(2018) Nazanin Namazi Sarvestani et al.   METABOLIC BRAIN DISEASE

DNA Methylation—a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy

(2018) Manish Mishra et al.   MOLECULAR NEUROBIOLOGY

Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View

(2018) Alice Biosa et al.   MOLECULAR NEUROBIOLOGY

Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication

(2018) Sanaz Nasoohi et al.   MOLECULAR NEUROBIOLOGY

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Diabetes mellitus and Parkinson disease

(2018) Gennaro Pagano et al.   NEUROLOGY

Mapping Txnip: Key connexions in progression of diabetic nephropathy

(2018) Anil Kumar et al.   Pharmacological Reports

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer

(2018) Robert Weil et al.   Frontiers in Immunology

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective effect of tropisetron on high glucose induced apoptosis and oxidative stress in PC12 cells: roles of JNK, P38 MAPKs, and mitochondria pathway

(2017) Azadeh Aminzadeh   METABOLIC BRAIN DISEASE

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

The TBK1-OPTN Axis Mediates Crosstalk Between Mitophagy and the Innate Immune Response: A Potential Therapeutic Target for Neurodegenerative Diseases

(2017) Lu He et al.   Neuroscience Bulletin

53BP1 contributes to regulation of autophagic clearance of mitochondria

(2017) Cha Kyung Youn et al.   Scientific Reports

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

(2017) Chang-Ki Oh et al.   Cell Reports

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

(2016) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Risk of Parkinson Disease in Diabetes Mellitus

(2016) Xuejing Yue et al.   MEDICINE

Involvement of Autophagic Pathway in the Progression of Retinal Degeneration in a Mouse Model of Diabetes

(2016) Ilaria Piano et al.   Frontiers in Cellular Neuroscience

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses

(2015) Huifang Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: Implication of cilostazol for diabetes mellitus-induced dementia

(2015) Kyoung Ja Kwon et al.   NEUROBIOLOGY OF DISEASE

Regulation of mitophagy in ischemic brain injury

(2015) Yang Yuan et al.   Neuroscience Bulletin

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice

(2013) Ling Wang et al.   EXPERIMENTAL NEUROLOGY

Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage

(2013) Rong-Yi Liu et al.   Neuroscience Bulletin

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

(2012) Samuel Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Diabetes, hyperglycaemia, and acute ischaemic stroke

(2012) Merel JA Luitse et al.   LANCET NEUROLOGY

Oxidative stress and macrophage foam cell formation during diabetes mellitus‐induced atherogenesis: Role of insulin therapy

(2012) Marielle Kaplan et al.   PHARMACOLOGY & THERAPEUTICS

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Oxidative Stress, Diabetes, and Diabetic Complications

(2009) Wei Wei et al.   HEMOGLOBIN

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY