Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy

The rapidly evolving view of lysosomal storage diseases

(2021) Giancarlo Parenti et al.   EMBO Molecular Medicine

Autophagy regulation by acetylation—implications for neurodegenerative diseases

(2021) Sung Min Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Dysfunction of chaperone-mediated autophagy in human diseases

(2021) Zhaozhong Liao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery

(2021) Anna K. Riebisch et al.   Pathogens

Mechanisms of mitochondrial cell death

(2021) Shashank Dadsena et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial outer membrane permeabilization at the single molecule level

(2021) Shashank Dadsena et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GSK3B induces autophagy by phosphorylating ULK1

(2021) Hye Young Ryu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Identification of autophagy‐related long non‐coding RNA prognostic signature for breast cancer

(2021) Qianxue Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of chaperone‑mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer

(2021) Ying Xuan et al.   Molecular Medicine Reports

p53 dynamics vary between tissues and are linked with radiation sensitivity

(2021) Jacob Stewart-Ornstein et al.   Nature Communications

Chaperone‐mediated autophagy affects tumor cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma

(2021) Dujuan Cao et al.   Thoracic Cancer

Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma

(2021) Jaione Auzmendi-Iriarte et al.   Frontiers in Aging Neuroscience

Identification and validation of an autophagy-related long non-coding RNA signature as a prognostic biomarker for patients with lung adenocarcinoma

(2021) Aimin Jiang et al.   Journal of Thoracic Disease

Identification and Validation of an Autophagy-Related lncRNA Signature for Patients With Breast Cancer

(2021) Ruyue Zhang et al.   Frontiers in Oncology

Chaperone Mediated Autophagy Substrates and Components in Cancer

(2021) Javiera Rios et al.   Frontiers in Oncology

Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis

(2021) Surinder M. Soond et al.   Pharmaceutics

Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR

(2021) Patricia Cruz‐Ruiz et al.   AGING CELL

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?

(2021) Geetika Garg et al.   Expert Opinion on Drug Discovery

Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19

(2021) Gustavo José da Silva Pereira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling: An Old Chap with New Roles

(2021) Jordan L. Morris et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel autophagy‐related lncRNA survival model for lung adenocarcinoma

(2021) Liwei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

(2021) Anne Slomp et al.   Cell Death & Disease

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

(2021) Hu Zhu et al.   Scientific Reports

The Unfolded Protein Response and Autophagy on the Crossroads of Coronaviruses Infections

(2021) Elisa B. Prestes et al.   Frontiers in Cellular and Infection Microbiology

Cellular Responses to the Efferocytosis of Apoptotic Cells

(2021) Charles Yin et al.   Frontiers in Immunology

A Signature of Autophagy-Related Long Non-coding RNA to Predict the Prognosis of Breast Cancer

(2021) Xiaoping Li et al.   Frontiers in Genetics

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

(2021) Komudi Singh et al.   Frontiers in Genetics

Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

(2021) Georgios Konstantinidis et al.   Cells

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

(2021) Yabin Zhang et al.   Cell Discovery

E3 Ubiquitin Ligase ASB17 Promotes Apoptosis by Ubiquitylating and Degrading BCLW and MCL1

(2021) Ge Yang et al.   Biology-Basel

Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism

(2021) Mehrshad Sadria et al.   Cell Communication and Signaling

Membrane supply and remodeling during autophagosome biogenesis

(2021) Rubén Gómez-Sánchez et al.   CURRENT OPINION IN CELL BIOLOGY

Beclin-1, an autophagy-related protein, is associated with the disease severity of COVID-19

(2021) Hamza Malik Okuyan et al.   LIFE SCIENCES

Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin

(2021) Michele Lai et al.   Scientific Reports

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

(2021) Hin Chu et al.   Science Advances

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

(2020) Ren-Qi Yao et al.   Autophagy

Microautophagy regulates proteasome homeostasis

(2020) Jianhui Li et al.   CURRENT GENETICS

The Rheb-TORC1 signaling axis functions as a developmental checkpoint

(2020) Tam Duong et al.   DEVELOPMENT

FLIP(L): the pseudo‐caspase

(2020) Peter Smyth et al.   FEBS Journal

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

(2020) Arjen J. Jakobi et al.   Nature Communications

LncRNAs as Therapeutic Targets for Autophagy-involved Cardiovascular Diseases: A Review of Molecular Mechanism and Therapy Strategy

(2020) Lihui Jin et al.   CURRENT MEDICINAL CHEMISTRY

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation and targeting of ATG8 protein lipidation

(2020) Sascha Martens et al.   Cell Discovery

Autophagy Regulation by the Translation Machinery and Its Implications in Cancer

(2020) Pilar Sarah Acevo-Rodríguez et al.   Frontiers in Oncology

Autophagosomes are formed at a distinct cellular structure

(2020) David M. Hollenstein et al.   CURRENT OPINION IN CELL BIOLOGY

Establishment and validation of a novel autophagy-related gene signature for patients with breast cancer

(2020) Jun-Xian Du et al.   GENE

COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks

(2020) Markus Blaess et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles

(2020) Sonia Emanuele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p62 overexpression promotes neoplastic stromal cell proliferation and is associated with the recurrence of giant cell tumor of bone

(2020) Shu Liu et al.   Oncology Letters

Canonical and Noncanonical Autophagy as Potential Targets for COVID-19

(2020) Melissa Bello-Perez et al.   Cells

Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques

(2020) Valentina Sora et al.   Frontiers in Cell and Developmental Biology

SIRT1 directly activates autophagy in human chondrocytes

(2020) Pradeep K. Sacitharan et al.   Cell Death Discovery

Coronavirus interactions with the cellular autophagy machinery

(2020) Katelyn Miller et al.   Autophagy

The lysosomal membrane ‐ export of metabolites and beyond

(2020) Sönke Rudnik et al.   FEBS Journal

Inhibition of class I PI3K enhances chaperone-mediated autophagy

(2020) S. Joseph Endicott et al.   JOURNAL OF CELL BIOLOGY

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma

(2020) Weige Zhou et al.   Biomed Research International

The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer

(2020) Marina Andrade-Tomaz et al.   Cells

Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

(2020) Nicole Wesch et al.   Cells

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

(2020) Nikita V. Ivanisenko et al.   Cell Death Discovery

ESCRT machinery plays a role in microautophagy in yeast

(2020) Shamsul Morshed et al.   BMC Molecular and Cell Biology

Starvation Responses Throughout the Caenorhabditiselegans Life Cycle

(2020) L. Ryan Baugh et al.   GENETICS

A Molecular Perspective on Sirtuin Activity

(2020) Carla S. S. Teixeira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel autophagy‐related lncRNA prognostic risk model for breast cancer

(2020) Xiaoying Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature

(2020) Wei Ma et al.   Journal of Translational Medicine

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

(2020) Xingyan Li et al.   Nature Communications

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

(2020) Kirill Gorshkov et al.   ACS Infectious Diseases

Taming the Autophagy as a Strategy for Treating COVID-19

(2020) Blanca Estela García-Pérez et al.   Cells

Autophagy in cardiovascular diseases: role of noncoding RNAs

(2020) Jinning Gao et al.   Molecular Therapy-Nucleic Acids

Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells

(2019) Alexander Agrotis et al.   Autophagy

Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells

(2019) Jeff Ji et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

(2019) Snahel Patel et al.   CELL DEATH AND DIFFERENTIATION

ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint

(2019) Fengjie Yuan et al.   NUCLEIC ACIDS RESEARCH

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

(2019) In Hye Lee   EXPERIMENTAL AND MOLECULAR MEDICINE

Metabolic regulation of lifespan from a C. elegans perspective

(2019) Kathrine B. Dall et al.   Genes and Nutrition

Regulation of Apoptotic Cell Clearance During Resolution of Inflammation

(2019) Simone Arienti et al.   Frontiers in Pharmacology

Mechanisms of Autophagy in Metabolic Stress Response

(2019) Angelina S. Gross et al.   JOURNAL OF MOLECULAR BIOLOGY

The Roles of Sirtuin Family Proteins in Cancer Progression

(2019) Erhu Zhao et al.   Cancers

Age-associated and tissue-specific decline in autophagic activity in the nematode C. elegans

(2018) Jessica T. Chang et al.   Autophagy

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in C. elegans development

(2018) Nicholas J. Palmisano et al.   DEVELOPMENTAL BIOLOGY

Targeting BCL-2 regulated apoptosis in cancer

(2018) Kirsteen J. Campbell et al.   Open Biology

Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death

(2018) Abdullah-Al Masum et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Design and synthesis of a luminescent iridium complex-peptide hybrid (IPH) that detects cancer cells and induces their apoptosis

(2018) Abdullah-Al Masum et al.   BIOORGANIC & MEDICINAL CHEMISTRY

So many roads: the multi-faceted regulation of autophagy induction

(2018) Angel F. Corona Velazquez et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Interconnection between DNA damage senescence inflammation and cancer

(2017) Udo S Gaipl   Frontiers in Bioscience-Landmark

Evidence for ESCRT- and clathrin-dependent microautophagy

(2017) Masahide Oku et al.   JOURNAL OF CELL BIOLOGY

Autophagosome Maturation and Fusion

(2017) Fulvio Reggiori et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA Damage in Stem Cells

(2017) Ilio Vitale et al.   MOLECULAR CELL

Pore formation by dimeric Bak and Bax: an unusual pore?

(2017) Rachel T. Uren et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Autophagy is a major regulator of beta cell insulin homeostasis

(2016) Yael Riahi et al.   DIABETOLOGIA

Mitochondrial DNA damage induced autophagy cell death and disease

(2016) Bennett Van Houten   Frontiers in Bioscience-Landmark

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

(2016) Beth Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNARE-mediated membrane fusion in autophagy

(2016) Yongyao Wang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy

(2016) Yijian Rao et al.   Nature Communications

Caspase-mediated cleavage of Beclin1 inhibits autophagy and promotes apoptosis induced by S1 in human ovarian cancer SKOV3 cells

(2015) Xiaoning Li et al.   APOPTOSIS

The integration of autophagy and cellular trafficking pathways via RAB GAPs

(2015) Andreas Kern et al.   Autophagy

Molecular interactions of theSaccharomyces cerevisiaeAtg1 complex provide insights into assembly and regulatory mechanisms

(2015) Leon H Chew et al.   Autophagy

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1

(2015) Mohammad Siddiqui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-mediated crosstalk between autophagy and apoptosis: Mutual adjustment or matter of dominance

(2015) ShrawanKumar Singh et al.   Journal of Cancer Research and Therapeutics

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

Xenophagy in herpes simplex virus replication and pathogenesis

(2014) Diane Alexander et al.   Autophagy

Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused

(2014) Daniel J Klionsky et al.   Autophagy

Regulation of autophagy by the Rab GTPase network

(2014) X Ao et al.   CELL DEATH AND DIFFERENTIATION

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

(2014) Haijian Wu et al.   International Journal of Biological Sciences

The C-terminal Domain of the Long Form of Cellular FLICE-inhibitory Protein (c-FLIPL) Inhibits the Interaction of the Caspase 8 Prodomain with the Receptor-interacting Protein 1 (RIP1) Death Domain and Regulates Caspase 8-dependent Nuclear Factor κB (NF-κB) Activation

(2014) Iyo Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Autosis: a new addition to the cell death tower of babel

(2014) C Muñoz-Pinedo et al.   Cell Death & Disease

Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site

(2013) Ikuko Koyama-Honda et al.   Autophagy

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

(2013) Laurence Lamy et al.   CANCER CELL

Autophagy and genomic integrity

(2013) A T Vessoni et al.   CELL DEATH AND DIFFERENTIATION

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

(2013) Qian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Complex between Atg7 and Caspase-9

(2013) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Autophagy via p53-Mediated Disruption of ULK1 in a SCA7 Polyglutamine Disease Model

(2013) Xin Yu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy

(2013) A. I. Fogel et al.   MOLECULAR AND CELLULAR BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Look people, “Atg” is an abbreviation for “autophagy-related.” That’s it.

(2012) Daniel J Klionsky   Autophagy

mTOR: The Master Regulator

(2012)   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

(2012) V Pagliarini et al.   CELL DEATH AND DIFFERENTIATION

Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion

(2012) Eduardo Cebollero et al.   CURRENT BIOLOGY

Modification by Ubiquitin-Like Proteins: Significance in Apoptosis and Autophagy Pathways

(2012) Umar-Faruq Cajee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

(2012) Min You et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis

(2012) Orsolya Kapuy et al.   Molecular BioSystems

Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis

(2011) Hua Li et al.   Autophagy

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

(2011) Elaine A. Dunlop et al.   Autophagy

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1

(2011) H. Li et al.   CANCER RESEARCH

SnapShot: Caspases

(2011) Guy S. Salvesen et al.   CELL

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Mechanisms of mitochondria and autophagy crosstalk

(2011) Angelika S. Rambold et al.   CELL CYCLE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction

(2011) E Pourkarimi et al.   CELL DEATH AND DIFFERENTIATION

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Aspartyl Aminopeptidase Is Imported from the Cytoplasm to the Vacuole by Selective Autophagy inSaccharomyces cerevisiae

(2011) Masaki Yuga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Quality control autophagy: A joint effort of ubiquitin, protein deacetylase and actin cytoskeleton

(2010) Joo-Yong Lee et al.   Autophagy

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

Crossing paths: interactions between the cell death machinery and growth factor survival signals

(2010) Gabriela Brumatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question

(2010) Franky Van Herreweghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy-mediated antigen processing in CD4+ T cell tolerance and immunity

(2010) Ludger Klein et al.   FEBS LETTERS

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Focusing on Autophagy

(2010)   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

(2010) M Djavaheri-Mergny et al.   ONCOGENE

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

Atg4D at the interface between autophagy and apoptosis

(2009) Virginie M.S. Betin et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic targeting of apoptosis pathways in cancer

(2009) David S Ziegler et al.   CURRENT OPINION IN ONCOLOGY

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

(2009) Anne Simonsen et al.   JOURNAL OF CELL BIOLOGY

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

An Initial Step of GAS-Containing Autophagosome-Like Vacuoles Formation Requires Rab7

(2009) Hitomi Yamaguchi et al.   PLoS Pathogens

Enhancing Immunity Through Autophagy

(2008) Christian Münz   Annual Review of Immunology

Caspase activation cascades in apoptosis

(2008) Susan E. Logue et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bcl-2-family proteins and hematologic malignancies: history and future prospects

(2008) J. C. Reed   BLOOD

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation

(2008) Tomoko Kawamata et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

A Brief History of Apoptosis: From Ancient to Modern Times

(2008) Aristidis Diamantis et al.   Oncology Research and Treatment

The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae

(2007) Heesun Cheong et al.   MOLECULAR BIOLOGY OF THE CELL