Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?
出版年份 2021 全文链接
标题
Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume -, Issue -, Pages 1-13
出版商
Informa UK Limited
发表日期
2021-04-22
DOI
10.1080/17460441.2021.1915980
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
- (2020) Nicola Mautone et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
- (2020) Monica Locatelli et al. Scientific Reports
- Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence
- (2019) Wioleta Grabowska et al. BIOGERONTOLOGY
- Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3
- (2019) Xingrun Zhang et al. Cell Discovery
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
- (2018) Luis Rajman et al. Cell Metabolism
- Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration
- (2018) Sandeep Singh et al. LIFE SCIENCES
- Impact of curcumin on sirtuins: A review
- (2018) Elham Zendedel et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Role of SIRT3 in the Brain Under Physiological and Pathological Conditions
- (2018) Elena Sidorova-Darmos et al. Frontiers in Cellular Neuroscience
- Natural polyphenols as sirtuin 6 modulators
- (2018) Minna Rahnasto-Rilla et al. Scientific Reports
- Cyclic tripeptide-based potent human SIRT7 inhibitors
- (2018) Shengchao Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
- (2018) Yijie Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development
- (2018) Weijie You et al. JOURNAL OF MEDICINAL CHEMISTRY
- SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle
- (2018) Aishwarya Iyer-Bierhoff et al. Cell Reports
- Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation
- (2018) Elisabet Cuyàs et al. Frontiers in Endocrinology
- Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)
- (2017) James Boslett et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
- (2017) Arang Kim et al. Nutrition Research and Practice
- Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
- (2017) Vinodkumar B. Pillai et al. Oncotarget
- Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial
- (2017) Robert K. Naviaux et al. Annals of Clinical and Translational Neurology
- Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules
- (2016) Weijie You et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling
- (2016) Yanping Miao et al. BRAIN RESEARCH BULLETIN
- NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
- (2016) Evandro Fei Fang et al. Cell Metabolism
- Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7
- (2016) Qiang Guan et al. EXPERIMENTAL GERONTOLOGY
- High-throughput screening of Sirtuin family of genes in breast cancer
- (2016) Mehri Igci et al. GENE
- Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans
- (2016) Jheelam Banerjee et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
- (2016) Mei T. Tran et al. NATURE
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- (2016) Michael S. Bonkowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- DNA repair targeted therapy: The past or future of cancer treatment?
- (2016) Navnath S. Gavande et al. PHARMACOLOGY & THERAPEUTICS
- The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer
- (2016) Wenhui Zhou et al. Cell Reports
- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- (2016) Orsolya M. Palacios et al. Aging-US
- A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth ofMycobacterium smegmatis
- (2015) Yongcong Tan et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- The role of sirtuins in cardiac disease
- (2015) Shouji Matsushima et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer
- (2015) Surinder Kumar et al. ANTIOXIDANTS & REDOX SIGNALING
- Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells
- (2015) Sang Chon Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease
- (2015) Sigurd D. Süssmuth et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells
- (2015) Min Gyeong Cheon et al. CANCER LETTERS
- The complex role of SIRT6 in carcinogenesis
- (2015) Batia Lerrer et al. CARCINOGENESIS
- SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice
- (2015) Louise Lantier et al. DIABETES
- Polymorphisms Falling Within Putative miRNA Target Sites in the 3′UTR Region ofSIRT2andDRD2Genes Are Correlated With Human Longevity
- (2015) Paolina Crocco et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
- (2015) R. Scott Turner et al. NEUROLOGY
- Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism
- (2015) Pedro Gomes et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Differential expression of sirtuins in the aging rat brain
- (2015) Nady Braidy et al. Frontiers in Cellular Neuroscience
- Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
- (2015) Tobias Rumpf et al. Nature Communications
- Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
- (2015) Vinodkumar B. Pillai et al. Nature Communications
- Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
- (2015) An Hu et al. Scientific Reports
- Huntington disease
- (2015) Gillian P. Bates et al. Nature Reviews Disease Primers
- SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
- (2014) Evi M. Mercken et al. AGING CELL
- Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
- (2014) Qinru Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chromone: A Valid Scaffold in Medicinal Chemistry
- (2014) Alexandra Gaspar et al. CHEMICAL REVIEWS
- The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
- (2014) Melroy X. Miranda et al. EUROPEAN HEART JOURNAL
- New assays and approaches for discovery and design of Sirtuin modulators
- (2014) Mike Schutkowski et al. Expert Opinion on Drug Discovery
- Sirtuin inhibitors as anticancer agents
- (2014) Jing Hu et al. Future Medicinal Chemistry
- Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”
- (2013) Diego Albani et al. AGE
- SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex
- (2013) Yolanda Olmos et al. ANTIOXIDANTS & REDOX SIGNALING
- SIRT5 desuccinylates and activates SOD1 to eliminate ROS
- (2013) Zhi-Feng Lin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats
- (2013) R. A. Kireev et al. BIOGERONTOLOGY
- Caloric restriction and its mimetics
- (2013) Shin-Hae Lee et al. BMB Reports
- SIRT1 and SIRT2: emerging targets in neurodegeneration
- (2013) Gizem Donmez et al. EMBO Molecular Medicine
- SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
- (2013) Yang Yang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
- (2013) Jessica L. Feldman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Vitexin Inhibits Inflammatory Pain in Mice by Targeting TRPV1, Oxidative Stress, and Cytokines
- (2013) Sergio M. Borghi et al. JOURNAL OF NATURAL PRODUCTS
- Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
- (2013) M. Gertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- (2012) Qi Zhang et al. EMBO Molecular Medicine
- Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review
- (2012) Venkat Koushik Pulla et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors
- (2012) Takayoshi Suzuki et al. JOURNAL OF MEDICINAL CHEMISTRY
- Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging
- (2012) Gaoxiang Jia et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
- (2012) Nagalingam R Sundaresan et al. NATURE MEDICINE
- A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
- (2012) Melanie Gertz et al. PLoS One
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
- (2011) Antero Salminen et al. AGEING RESEARCH REVIEWS
- Flavonoids as inhibitors of human CD38
- (2011) Esther Kellenberger et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
- (2011) Michele M. Maxwell et al. HUMAN MOLECULAR GENETICS
- AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
- (2011) Antero Salminen et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- (2011) Hyunkyung Jeong et al. NATURE MEDICINE
- Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
- (2011) Yuncheng Wu et al. NEUROSIGNALS
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
- (2011) N. R. Sundaresan et al. Science Signaling
- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- Regulation of SIRT1 in cellular functions: Role of polyphenols
- (2010) Sangwoon Chung et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
- (2010) Hyun-Seok Kim et al. CANCER CELL
- Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion
- (2010) Chiao-Po Hsu et al. CIRCULATION
- Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
- (2010) Tsutomu Sasaki et al. ENDOCRINOLOGY
- Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms
- (2010) Nobuko Matsushita et al. GENES TO CELLS
- SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells
- (2010) Nargis Nasrin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
- (2010) Barrie Peck et al. MOLECULAR CANCER THERAPEUTICS
- Genomic instability — an evolving hallmark of cancer
- (2010) Simona Negrini et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
- (2010) Shin-ichiro Imai et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
- (2009) J. Mark Davis et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity
- (2009) Yingjia Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Sirtuins inhibitors: The approach to affinity and selectivity
- (2009) Yana Cen BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
- (2009) Takashi Nakagawa et al. CELL
- Human longevity and 11p15.5: a study in 1321 centenarians
- (2009) Francesco Lescai et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)
- (2009) Kilian Huber et al. JOURNAL OF MEDICINAL CHEMISTRY
- The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
- (2009) Diego Albani et al. JOURNAL OF NEUROCHEMISTRY
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- (2009) Carles Cantó et al. NATURE
- SIRT1 and insulin resistance
- (2009) Fengxia Liang et al. Nature Reviews Endocrinology
- High Histone Deacetylase 7 (HDAC7) Expression Is Significantly Associated with Adenocarcinomas of the Pancreas
- (2008) Mehdi Ouaïssi et al. ANNALS OF SURGICAL ONCOLOGY
- Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator
- (2008) Sonia Lain et al. CANCER CELL
- Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice
- (2008) Rui-Hong Wang et al. CANCER CELL
- The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
- (2008) Yasukazu Nakahata et al. CELL
- Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
- (2008) Olesya Vakhrusheva et al. CIRCULATION RESEARCH
- Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease
- (2008) Judit Pallos et al. HUMAN MOLECULAR GENETICS
- SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1
- (2008) Fan Lan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode
- (2008) Robert C. Neugebauer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
- (2008) G. Ramadori et al. JOURNAL OF NEUROSCIENCE
- SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
- (2008) N. R. Sundaresan et al. MOLECULAR AND CELLULAR BIOLOGY
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
- (2008) Yi Liu et al. NATURE
- Paths of Convergence: Sirtuins in Aging and Neurodegeneration
- (2008) Li Gan et al. NEURON
- Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
- (2008) E Lara et al. ONCOGENE
- The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
- (2008) Ron Firestein et al. PLoS One
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started