Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Neuregulin‐1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase‐1 in myocardial ischaemia‐reperfusion injury

(2021) Fuhua Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease

(2020) Qi Mao et al.   ACTA PHARMACOLOGICA SINICA

Protective effect of Hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α

(2020) Mehrnaz Mehrabani et al.   Biochemistry and Cell Biology

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

HIF‑1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia‑reperfusion injury in a rat MCAO model

(2020) Jun Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease

(2020) Pascaline Aimé et al.   NEUROBIOLOGY OF DISEASE

Hypoxia preconditioning protects neuronal cells against traumatic brain injury through stimulation of glucose transport mediated by HIF-1α/GLUTs signaling pathway in rat

(2020) Xiaogang Wu et al.   NEUROSURGICAL REVIEW

Physical exercise in the prevention and treatment of Alzheimer's disease

(2020) Adrian De la Rosa et al.   Journal of Sport and Health Science

HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

(2020) Guangping Zhang et al.   Aging-US

Treatment and management of cognitive dysfunction in patients with multiple sclerosis

(2020) John DeLuca et al.   Nature Reviews Neurology

Long-term changes in metabolic brain network drive memory impairments in rats following neonatal hypoxia-ischemia

(2020) Pamella Nunes Azevedo et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Loss of hypoxia-inducible factor 1α affects hypoxia tolerance in larval and adult zebrafish ( Danio rerio )

(2020) Milica Mandic et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neurovascular Unit Dysfunction and Neurodegenerative Disorders

(2020) Xing Yu et al.   Frontiers in Neuroscience

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

(2020) Luodan Yang et al.   Translational Neurodegeneration

The Links between Cardiovascular Diseases and Alzheimer's Disease

(2020) Jerzy Leszek et al.   Current Neuropharmacology

Mitochondrial Respiration Changes in R6/2 Huntington’s Disease Model Mice during Aging in a Brain Region Specific Manner

(2020) Johannes Burtscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Parkinson’s disease: etiopathogenesis and treatment

(2020) Joseph Jankovic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Fear memory is impaired in hypobaric hypoxia: Role of synaptic plasticity and neuro-modulators in limbic region

(2020) Punita Kumari et al.   LIFE SCIENCES

The Role of Neurovascular System in Neurodegenerative Diseases

(2020) Ajmal Ahmad et al.   MOLECULAR NEUROBIOLOGY

Chronic Traumatic Encephalopathy and Neuropathological Comorbidities

(2020) Thor D. Stein et al.   SEMINARS IN NEUROLOGY

HIF-1α Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury

(2020) Yuanjian Fang et al.   Frontiers in Cellular Neuroscience

Orexin and Parkinson's disease: A protective neuropeptide with therapeutic potential

(2020) Cui Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Identification of contributing genes of Huntington’s disease by machine learning

(2020) Jack Cheng et al.   BMC Medical Genomics

Hypoxia in multiple sclerosis; is it the chicken or the egg?

(2020) Sebok K Halder et al.   BRAIN

Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease

(2020) A.M. Thompson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Hypoxic stress visualized in the cervical spinal cord of ALS patients

(2020) Toru Yamashita et al.   NEUROLOGICAL RESEARCH

Advances in the Treatment of Multiple Sclerosis

(2020) Carolyn Goldschmidt et al.   NEUROLOGIC CLINICS

Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-κB p65/Hif-1α Signaling Pathway

(2019) Rui Liu et al.   JOURNAL OF IMMUNOLOGY

HIF1α-mediated AIMP3 suppression delays stem cell aging via the induction of autophagy

(2019) Chul Kim et al.   AGING CELL

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

(2019) Strowitzki et al.   Cells

Epidemiology of amyotrophic lateral sclerosis

(2019) Elisa Longinetti et al.   CURRENT OPINION IN NEUROLOGY

Caffeine inhibits hypoxia-induced nuclear accumulation in HIF-1α and promotes neonatal neuronal survival

(2019) Hsiu-Ling Li et al.   EXPERIMENTAL NEUROLOGY

Modeling the regulation of p53 activation by HIF‐1 upon hypoxia

(2019) Ping Wang et al.   FEBS LETTERS

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Environmental factors and risk of multiple sclerosis: Findings from meta-analyses and Mendelian randomization studies

(2019) Lazaros Belbasis et al.   Multiple Sclerosis Journal

Imaging Hypoxic Stress and the Treatment of Amyotrophic Lateral Sclerosis with Dimethyloxalylglycine in a Mice Model

(2019) Emi Nomura et al.   NEUROSCIENCE

HIF-transcribed p53 chaperones HIF-1α

(2019) Esha Madan et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of ischaemic neural progenitor proliferation: a regulatory role of the HIF‐1α‐CBX7 pathway

(2019) H.‐Y. Chiu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pharmacological HIF1 Inhibition Eliminates Downregulation of the Pentose Phosphate Pathway and Prevents Neuronal Apoptosis in Rat Hippocampus Caused by Severe Hypoxia

(2019) Oleg Vetrovoy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

(2019) Xing-Liang Yang et al.   Frontiers in Cell and Developmental Biology

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

(2018) Jianhua Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Erythropoietin attenuates motor neuron programmed cell death in a burn animal model

(2018) Sheng-Hua Wu et al.   PLoS One

Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson’s Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function

(2018) Xuan Li et al.   Frontiers in Aging Neuroscience

Respiratory measures in amyotrophic lateral sclerosis

(2018) Noah Lechtzin et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle

(2018) Runze Yang et al.   Multiple Sclerosis Journal

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

(2018) Ju Zheng et al.   Frontiers in Molecular Neuroscience

Reciprocal regulations between miRNAs and HIF-1α in human cancers

(2018) Wanli Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding the Role of Hypoxia Inducible Factor During Neurodegeneration for New Therapeutics Opportunities

(2018) Amalia Merelli et al.   Current Neuropharmacology

Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1α) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning

(2018) Lauren Carrica et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Resveratrol Induces Apoptosis in Murine Prostate Cancer Cells via Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Reactive Oxygen Species (ROS)/P53 Signaling

(2018) Delong Wang et al.   MEDICAL SCIENCE MONITOR

Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease

(2018) Mei-Fang Liu et al.   Frontiers in Neuroscience

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

(2018) Tomohiro Yamaki et al.   Jove-Journal of Visualized Experiments

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Hypoxia-inducible factor-1α: a promising therapeutic target for autoimmune diseases

(2017) Shi-Yang Guan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Acute hypoxic stress: Effect on blood parameters, antioxidant enzymes, and expression of HIF-1alpha and GLUT-1 genes in largemouth bass ( Micropterus salmoides )

(2017) S. Yang et al.   FISH & SHELLFISH IMMUNOLOGY

Cold Inducible RNA Binding Protein Is Involved in Chronic Hypoxia Induced Neuron Apoptosis by Down-Regulating HIF-1α Expression and Regulated By microRNA-23a

(2017) Xiaoming Chen et al.   International Journal of Biological Sciences

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model

(2017) Chuang Guo et al.   NEUROPSYCHOPHARMACOLOGY

Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats

(2017) Rongli Yang et al.   NEUROSCIENCE LETTERS

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Intermittent hypoxia produces Alzheimer disease?

(2017) Sosuke Yagishita et al.   Oncotarget

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons

(2017) Shanshan Sun et al.   Redox Biology

Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice

(2017) June Zhou et al.   Frontiers in Endocrinology

Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate

(2017) Stephen J. DeVience et al.   Scientific Reports

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways

(2017) Jeong Yeon Kim et al.   Scientific Reports

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis

(2016) Xian-Wu Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment

(2016) Osigbemhe Iyalomhe et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hypoxia-inducible factor 1 in autoimmune diseases

(2016) Wei Deng et al.   CELLULAR IMMUNOLOGY

Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

(2016) Daniel Gruneberg et al.   EXPERIMENTAL NEUROLOGY

Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke

(2016) Philipp Barteczek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Roles of HIF-1α, VEGF, and NF-κB in Ischemic Preconditioning-Mediated Neuroprotection of Hippocampal CA1 Pyramidal Neurons Against a Subsequent Transient Cerebral Ischemia

(2016) Jae-Chul Lee et al.   MOLECULAR NEUROBIOLOGY

Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

(2016) Lexiao Li et al.   NEUROBIOLOGY OF DISEASE

The neuroprotection of hypoxic preconditioning on rat brain against traumatic brain injury by up-regulated transcription factor Nrf2 and HO-1 expression

(2016) Longfei Shu et al.   NEUROSCIENCE LETTERS

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

(2016) Marco Tafani et al.   Oxidative Medicine and Cellular Longevity

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

EPO induces changes in synaptic transmission and plasticity in the dentate gyrus of rats

(2016) William Almaguer-Melian et al.   SYNAPSE

Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus and characterization of immature neurons along the septotemporal axis

(2016) Ian Mahar et al.   Scientific Reports

High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

(2016) Hyun Jik Lee et al.   Scientific Reports

Parkinson's disease as a result of aging

(2015) Manuel Rodriguez et al.   AGING CELL

Emerging Concepts in Alzheimer's Disease

(2015) Harry V. Vinters   Annual Review of Pathology-Mechanisms of Disease

The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

(2015) Divya Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioenergetics profile of CD4 + T cells in relapsing remitting multiple sclerosis subjects

(2015) Lidia De Riccardis et al.   JOURNAL OF BIOTECHNOLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Treating the whole body in Huntington's disease

(2015) Jeffrey B Carroll et al.   LANCET NEUROLOGY

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

(2015) M.-G. Ryou et al.   NEUROSCIENCE

Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice

(2015) Chuang Guo et al.   Frontiers in Aging Neuroscience

An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis

(2015) Neeta Garg et al.   Brain and Behavior

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism

(2015) Siyoung Cho et al.   Oncotarget

Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved

(2014) Elisa Nicoloso Simões Pires et al.   BRAIN RESEARCH

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

The Novel Multi-Target Iron Chelator, M30 Modulates HIF-1α-Related Glycolytic Genes and Insulin Signaling Pathway in the Frontal Cortex of APP/PS1 Alzheimer’s Disease Mice

(2014) Danit Mechlovich et al.   Current Alzheimer Research

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease

(2014) Daniel Santos et al.   MOLECULAR NEUROBIOLOGY

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis

(2014) Yimin Sun et al.   Neural Regeneration Research

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease

(2014) Ya Feng et al.   NEUROSCIENCE LETTERS

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis–Ekbom Disease)

(2014) Christopher J. Earley et al.   SLEEP MEDICINE

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

(2014) Ana Catarina Pronto-Laborinho et al.   Biomed Research International

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Impaired Cytoplasmic-Nuclear Transport of Hypoxia-Inducible Factor-1α in Amyotrophic Lateral Sclerosis

(2013) Yuko Nagara et al.   BRAIN PATHOLOGY

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke

(2013) Rachel E. Speer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

(2013) Zhen Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid Protection of Oligodendrocytes against Excitotoxin Involving Hypoxia-Inducible Factor-1  in a Cell-Type-Specific Manner

(2013) Y.-Y. Sun et al.   JOURNAL OF NEUROSCIENCE

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

(2013) Yi-Lin Cheng et al.   NEUROBIOLOGY OF DISEASE

Review: Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function

(2013) S. M. G. Braun et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2

(2013) Diana Wiesner et al.   PLoS One

Intermittent Hypoxia Can Aggravate Motor Neuronal Loss and Cognitive Dysfunction in ALS Mice

(2013) Sung-Min Kim et al.   PLoS One

Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels

(2013) Fahmeed Hyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1α is upregulated in human mesenchymal stem cells

(2013) Sami Palomäki et al.   STEM CELLS

Evaluation of neurobehavioral deficits following different severities of cerebral ischemia in rats: A comparison between the modified hole board test and the Morris water maze test

(2012) Maria Lucia Gordan et al.   BEHAVIOURAL BRAIN RESEARCH

Antioxidant and bioenergetic coupling between neurons and astrocytes

(2012) Seila Fernandez-Fernandez et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis

(2012) Michael A Palladino et al.   Reproductive Biology and Endocrinology

Caspase-3 activation as a bifurcation point between plasticity and cell death

(2012) Shikha Snigdha et al.   Neuroscience Bulletin

Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases

(2011) Z. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Early and Progressive Impairment of Spinal Blood Flow—Glucose Metabolism Coupling in Motor Neuron Degeneration of ALS Model Mice

(2011) Kazunori Miyazaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism

(2010) Caroline M. Lambert et al.   CARDIOVASCULAR RESEARCH

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Hippocampus development and function: role of epigenetic factors and implications for cognitive disease

(2010) PS Lagali et al.   CLINICAL GENETICS

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

(2010) Heidi Menrad et al.   HEPATOLOGY

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

(2010) Jens Leander Johansen et al.   JOURNAL OF NEUROCHEMISTRY

Environmental factors and their timing in adult-onset multiple sclerosis

(2010) Adam E. Handel et al.   Nature Reviews Neurology

Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients

(2010) C. Moreau et al.   NEUROSCIENCE

Murine Neural Stem/Progenitor Cells Protect Neurons against Ischemia by HIF-1α–Regulated VEGF Signaling

(2010) Kate M. Harms et al.   PLoS One

Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury

(2010) Masanori Iwai et al.   STROKE

HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease

(2009) Zoya Niatsetskaya et al.   ANTIOXIDANTS & REDOX SIGNALING

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

(2009) O. O. Ogunshola et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia

(2009) R. Ann Sheldon et al.   DEVELOPMENTAL NEUROSCIENCE

BCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α

(2009) Ni Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of microvascular failure in central nervous system injury—synergistic roles of NKCC1 and SUR1/TRPM4

(2009) J. Marc Simard et al.   JOURNAL OF NEUROSURGERY

Signaling pathway involved in hypoxia-inducible factor-1α regulation in hypoxic-ischemic cortical neurons in vitro

(2009) Li Zhang et al.   NEUROSCIENCE LETTERS

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1α and erythropoietin in rats

(2008) Guo-Jun Gu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-α-mediated cell death

(2008) Song-yi Yao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE