Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential

Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

(2020) Wei Zhang et al.   Cancer Cell International

Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner

(2020) ChitChoon Lim et al.   Cancer Cell International

USP15 potentiates NF‐κB activation by differentially stabilizing TAB2 and TAB3

(2020) Qiaoqiao Zhou et al.   FEBS Journal

USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination

(2020) Yana Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies

(2020) Blanca T. Gutierrez-Diaz et al.   TRENDS IN IMMUNOLOGY

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis

(2020) Madeline Niederkorn et al.   Cell Reports

Epigenetic Silencing of Ubiquitin Specific Protease 4 by Snail1 Contributes to Macrophage-Dependent Inflammation and Therapeutic Resistance in Lung Cancer

(2020) Chao-Yang Lai et al.   Cancers

Cancer Stem Cells: Devil or Savior—Looking behind the Scenes of Immunotherapy Failure

(2020) Lorenzo Castagnoli et al.   Cells

USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression

(2020) Bing Han et al.   Aging-US

N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure–activity relationships and X-ray crystallographic studies

(2020) Minglei Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance

(2020) Hao Chen et al.   INVESTIGATIONAL NEW DRUGS

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

(2020) Paul R. Leger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia-induced USP22-BMI1 axis promotes the stemness and malignancy of glioma stem cells via regulation of HIF-1α

(2020) Guan-Zhong Qiu et al.   LIFE SCIENCES

CRISPR screen in regulatory T cells reveals modulators of Foxp3

(2020) Jessica T. Cortez et al.   NATURE

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Mass Spectrometry Technologies for Deciphering the Ubiquitin Code

(2020) Fumiaki Ohtake   TRENDS IN BIOCHEMICAL SCIENCES

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

(2020) Nathan J. Schauer et al.   Scientific Reports

The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment

(2020) Yajing Mi et al.   Frontiers in Immunology

The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer

(2020) Marek Nowak et al.   Cells

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

(2020) Yu Wang et al.   Cell Communication and Signaling

BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

(2020) Lingfei Jia et al.   Cell Stem Cell

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

(2020) Chunxiao Li et al.   Molecular Cancer

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity in Vitro and in Vivo

(2020) Yamini M. Ohol et al.   MOLECULAR CANCER THERAPEUTICS

The role of ubiquitination and deubiquitination in cancer metabolism

(2020) Tianshui Sun et al.   Molecular Cancer

Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1

(2020) Li Huang et al.   Cell Reports

USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2

(2020) Lei-lei Chen et al.   Science Advances

Cancer Stem Cells: The Architects of the Tumor Ecosystem

(2019) Briana C. Prager et al.   Cell Stem Cell

WNT/β-catenin pathway activation correlates with immune exclusion across human cancers

(2019) Jason J. Luke et al.   CLINICAL CANCER RESEARCH

USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation

(2019) Shinji Kusakabe et al.   JOURNAL OF VIROLOGY

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review)

(2019) Mingli Hu et al.   ONCOLOGY REPORTS

Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy

(2019) Changqing Fu et al.   OncoTargets and Therapy

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

(2019) John V. Dzimianski et al.   PLoS Pathogens

Ubiquitin-specific protease 4 promotes glioblastoma multiforme via activating ERK pathway

(2019) Yudong Zhou et al.   OncoTargets and Therapy

Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers

(2019) Zhe Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers

(2019) Masaru Katoh   CLINICAL SCIENCE

USP7: Structure, substrate specificity, and inhibition

(2019) Alexandra Pozhidaeva et al.   DNA REPAIR

Extracellular matrix-mediated regulation of cancer stem cells and chemoresistance

(2019) Yazmin Brown et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

(2019) Xiaohong Xia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1

(2019) Cao-Qi Lei et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Ubiquitin-specific protease 14 suppresses cell proliferation and synergizes with chemotherapeutic agents in neuroblastoma

(2019) Yang Yu et al.   MOLECULAR CANCER THERAPEUTICS

Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma

(2019) Beibei Sha et al.   APOPTOSIS

A PAK5–DNPEP–USP4 axis dictates breast cancer growth and metastasis

(2019) Nanxi Geng et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of ubiquitin‑specific protease�14 promotes connexin�32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells

(2019) Huimin Luo et al.   ONCOLOGY REPORTS

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

(2019) Marina Ruiz de Galarreta et al.   Cancer Discovery

The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation

(2019) Lian Li et al.   EBioMedicine

PTEN Tumor-Suppressor: The Dam of Stemness in Cancer

(2019) Francesca Luongo et al.   Cancers

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression

(2019) Anders Etzerodt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin‑specific peptidase 22 promotes proliferation and metastasis in human colon cancer

(2019) Xiao Yuan et al.   Oncology Letters

USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity

(2019) Xing Huang et al.   Cancer Immunology Research

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation

(2019) Sarah E. Clark et al.   Frontiers in Immunology

Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling

(2019) Hongxia Liu et al.   Aging-US

Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics

(2019) M Nikanjam et al.   ANNALS OF ONCOLOGY

Deubiquitination and stabilization of estrogen receptor α by ubiquitin-specific protease 7 promotes breast tumorigenesis

(2019) Xiaohong Xia et al.   CANCER LETTERS

USP14 Inhibition Regulates Tumorigenesis by Inducing Autophagy in Lung Cancer In Vitro

(2019) Kyung Ho Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance

(2019) Masoud Najafi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma

(2019) Liling Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors

(2019) Nathan J. Schauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cancer stem cell (CSC) resistance drivers

(2019) Masoud Najafi et al.   LIFE SCIENCES

Wnt signaling and drug resistance in cancer

(2019) Zheng Zhong et al.   MOLECULAR PHARMACOLOGY

MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway

(2019) Wei Yang et al.   ONCOGENE

IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15‐Dependent BMI1 Stability

(2019) Lixing Zhang et al.   Advanced Science

Functional analysis of deubiquitylating enzymes in tumorigenesis and development

(2019) Ji Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer

(2019) Keqiang Zhang et al.   Cell Communication and Signaling

Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications

(2019) Sandra Grund-Gröschke et al.   Cell Communication and Signaling

Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer

(2019) Fei Guo et al.   CELL DEATH AND DIFFERENTIATION

Blocking PD-L1 for anti-liver cancer immunity: USP22 represents a critical cotarget

(2019) Xing Huang et al.   Cellular & Molecular Immunology

KYA1797K down-regulates PD-L1 in colon cancer stem cells to block immune evasion by suppressing the β-catenin/STT3 signaling pathway

(2019) Zhiyan Ruan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival

(2019) Yuanming He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting the human immune system with single cell RNA sequencing technology

(2019) Gang Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Emerging role of ubiquitin-specific protease 14 in oncogenesis and development of tumor: Therapeutic implication

(2019) Bing Liu et al.   LIFE SCIENCES

Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update

(2019) Joseph A. Clara et al.   Nature Reviews Clinical Oncology

Tumor Cell–Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer

(2019) Jinyang Li et al.   Cancer Immunology Research

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

(2019) Katie L. Owen et al.   Cancers

The role of STAT3 in leading the crosstalk between human cancers and the immune system

(2018) Yu Wang et al.   CANCER LETTERS

Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization

(2018) Guan-Zhong Qiu et al.   CANCER SCIENCE

β-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer

(2018) Chengming Ding et al.   CELL PROLIFERATION

Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells

(2018) Varun Sasidharan Nair et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma

(2018) Reinaldo Franqui-Machin et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of deubiquitinase USP7 overcomes bortezomib resistance by suppressing NF-κB signaling pathway in multiple myeloma

(2018) Yao Yao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma

(2018) Satoru Shinriki et al.   JOURNAL OF PATHOLOGY

Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma

(2018) Li Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms

(2018) Xujing Wang et al.   MEDICAL SCIENCE MONITOR

AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression

(2018) Binghao Li et al.   Cancer Immunology Research

Role of tumor microenvironment in cancer stem cell chemoresistance and recurrence

(2018) Madhurima Das et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance

(2018) Etienne Giroux-Leprieur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

(2018) Yi-Chang Wang et al.   Nature Communications

USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer

(2018) Ying Fu et al.   Cancer Medicine

Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition

(2018) Chan Qiu et al.   Aging-US

Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention

(2018) Lewis A. Quayle et al.   CLINICAL & EXPERIMENTAL METASTASIS

USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis

(2018) Aihui Ma et al.   ONCOGENE

Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer

(2018) Jayati Chakrabarti et al.   Oncotarget

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

(2018) Francesca Ferrandino et al.   Frontiers in Immunology

Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer

(2018) Ann Hanna et al.   OncoImmunology

USP14-mediated IκBα degradation exacerbates NF-κB activation and IL-1β-stimulated chondrocyte dedifferentiation

(2018) Ming Li et al.   LIFE SCIENCES

USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells

(2017) Ruirong Lin et al.   FEBS LETTERS

The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases

(2017) Chon-Kit Chou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mazy case of Notch and immunoregulatory cells

(2017) Paola Grazioli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ubiquitin-specific protease 14 regulates LPS-induced inflammation by increasing ERK1/2 phosphorylation and NF-κB activation

(2017) Ningning Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dishevelled proteins and CYLD reciprocally regulate each other in CML cell lines

(2017) Ceyda Çalışkan et al.   MOLECULAR BIOLOGY REPORTS

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

(2017) Andrew P. Turnbull et al.   NATURE

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

(2017) Gerald Gavory et al.   Nature Chemical Biology

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance

(2017) Guan-Zhong Qiu et al.   PHARMACOLOGY & THERAPEUTICS

USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein

(2017) Yue Ma et al.   Oncotarget

USP7 Is a Tumor-Specific WNT Activator for APC -Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

(2017) Laura Novellasdemunt et al.   Cell Reports

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer

(2017) Lucile Jeusset et al.   Cancers

The role of ubiquitin-specific protease 14 (USP14) in cell adhesion-mediated drug resistance (CAM-DR) of multiple myeloma cells

(2016) Xiaohong Xu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

(2016) Gloria Lopez-Castejon et al.   MEDIATORS OF INFLAMMATION

Reciprocal activation between STAT3 and miR-181b regulates the proliferation of esophageal cancer stem-like cells via the CYLD pathway

(2016) Dan-dan Xu et al.   Molecular Cancer

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

(2016) Sabrina Torre et al.   NATURE IMMUNOLOGY

Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects

(2016) Yuval Shaked   Nature Reviews Clinical Oncology

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease

(2016) H van Andel et al.   ONCOGENE

Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer

(2016) Li Zhang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

The tumour suppressor CYLD regulates the p53 DNA damage response

(2016) Vanesa Fernández-Majada et al.   Nature Communications

Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

(2016) A Paulus et al.   Blood Cancer Journal

Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinoma

(2016) Su Jin Hwang et al.   Scientific Reports

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

(2016) Liqing Wang et al.   EBioMedicine

USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer

(2015) Haibo Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deubiquitinases and the new therapeutic opportunities offered to cancer

(2015) R. Pfoh et al.   ENDOCRINE-RELATED CANCER

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

(2015) Luke Boulter et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Ubiquitin-Specific Protease 4 Promotes Th17 Cell Function under Inflammation by Deubiquitinating and Stabilizing RORγt

(2015) Jing Yang et al.   JOURNAL OF IMMUNOLOGY

USP22 promotes tumor progression and induces epithelial–mesenchymal transition in lung adenocarcinoma

(2015) Jing Hu et al.   LUNG CANCER

Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer

(2015) Sun-Il Yun et al.   Molecular Oncology

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+T cells through regulation of IL-10

(2015) Chunmei Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

(2015) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Clinical significance of CYLD downregulation in breast cancer

(2014) Mitsuhiro Hayashi et al.   BREAST CANCER RESEARCH AND TREATMENT

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?

(2014) Valentin S. Bruttel et al.   Frontiers in Immunology

Cancer Stem Cells Activate STAT3 the EZ Way

(2013) Shaun D. Fouse et al.   CANCER CELL

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

(2013) Jorg van Loosdregt et al.   IMMUNITY

Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of β-Catenin

(2013) Ning Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2

(2013) Nikolaos Patsoukis et al.   MOLECULAR AND CELLULAR BIOLOGY

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

(2013) Y-H Fan et al.   Cell Death & Disease

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

(2013) H Jung et al.   Oncogenesis

Cancer Stem Cells: Distinct Entities or Dynamically Regulated Phenotypes?

(2012) Y. Li et al.   CANCER RESEARCH

Cell Plasticity and Heterogeneity in Cancer

(2012) N. D. Marjanovic et al.   CLINICAL CHEMISTRY

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Deubiquitination of NF- B by Ubiquitin-Specific Protease-7 promotes transcription

(2012) A. Colleran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia

(2011) Teresa D’Altri et al.   CELL CYCLE

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation

(2011) Kamyar Hadian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

(2011) P Liu et al.   LEUKEMIA

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

(2011) S Kuphal et al.   ONCOGENE

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Notch-1 associates with IKKα and regulates IKK activity in cervical cancer cells

(2008) L L Song et al.   ONCOGENE