Article
Immunology
Min Chao, Nan Liu, Zhichuan Sun, Yongli Jiang, Tongtong Jiang, Meng Xv, Lintao Jia, Yanyang Tu, Liang Wang
Summary: Sox9, an upregulated transcription factor in clinical gliomas associated with poor prognosis, promotes migration and invasion of glioma cells and in vivo tumor development. It functions downstream of the TGF-beta pathway, where TGF-beta signaling prevents proteasomal degradation of Sox9 protein in glioma cells. These findings provide new insights into the interaction between TGF-beta signaling and oncogenic transcription factors, with implications for targeted therapy and prognostic assessment of gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Xu Wang, Shuangshaung Wu, Wenjie Wu, Wenqing Zhang, Linman Li, Qian Liu, Zhimin Yan
Summary: This study found that Candida albicans infection can promote the occurrence and progression of oral cancer, and attract tumor-associated macrophages (TAMs) infiltration. Further analysis showed that the activation of the IL-17A/IL-17RA signaling pathway played an important role in excessive TAMs infiltration in the tumor inflammatory microenvironment caused by Candida infection.
Article
Oncology
Yu-Fu Zhou, Shu-Shu Song, Meng-Xin Tian, Zheng Tang, Han Wang, Yuan Fang, Wei-Feng Qu, Xi-Fei Jiang, Chen-Yang Tao, Run Huang, Pei-Yun Zhou, Shi-Guo Zhu, Jian Zhou, Jia Fan, Wei-Ren Liu, Ying-Hong Shi
Summary: The study revealed that CBS plays an anti-tumor role in HCC by promoting cellular apoptosis, inhibiting tumor growth through inactivation of the PRRX2/IL-6/STAT3 pathway. Additionally, CBS can reduce the abundance of tumor-infiltrating Tregs, thus suppressing immune evasion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong, Bo Xiang
Summary: A circular RNA called circPVT1 was found to be significantly upregulated in nasopharyngeal carcinoma (NPC) cells and tissue samples. It was shown to promote invasion and metastasis of NPC cells through interaction with beta-TrCP and stabilization of c-Myc protein. The study revealed a positive feedback loop involving c-Myc and an RNA splicing factor SRSF1, which enhances the production of circPVT1. The findings suggested that circPVT1 could serve as a prognostic biomarker or therapeutic target in patients with NPC.
Article
Medicine, Research & Experimental
Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen, Yi Wang
Summary: This study revealed that SCUBE1 derived from cancer associated fibroblasts (CAFs) can enhance the malignancy and stemness of hepatocellular carcinoma (HCC) cells through the Shh pathway. This study aims to provide new perspectives for future HCC studies and offer new strategies for HCC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ziwen Pan, Rongrong Zhao, Boyan Li, Yanhua Qi, Wei Qiu, Qindong Guo, Shouji Zhang, Shulin Zhao, Hao Xu, Ming Li, Zijie Gao, Yang Fan, Jianye Xu, Huizhi Wang, Shaobo Wang, Jiawei Qiu, Qingtong Wang, Xing Guo, Lin Deng, Ping Zhang, Hao Xue, Gang Li
Summary: This study reveals the significant role of circNEIL3 in promoting gliomagenesis and malignant progression, as well as in driving macrophage infiltration into the tumour microenvironment. CircNEIL3 may serve as a potential prognostic biomarker and therapeutic target for gliomas.
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biology
Hemanth Kumar Kandikattu, Murli Manohar, Alok Kumar Verma, Sandeep Kumar, Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Anil Mishra
Summary: Accumulated macrophages in the pancreas play a crucial role in promoting the pathogenesis of chronic pancreatitis through the NLRP3-IL-18 pathway, leading to the development of pancreatic malignancy.
LIFE SCIENCE ALLIANCE
(2021)
Article
Cell Biology
Ye Tan, Di Wu, Ze-Yu Liu, Hong-Qiang Yu, Xiang-Ru Zheng, Xiao-Tong Lin, Ping Bie, Lei-Da Zhang, Chuan-Ming Xie
Summary: HLTF downregulation in hepatocellular carcinoma is associated with beta-TrCP-mediated degradation, leading to increased p62 transcriptional activity and mTOR activation. The decreased expression of HLTF is positively correlated with elevated expression of beta-TrCP, p62, and p-mTOR in HCC patients. This finding reveals a new oncogenic driver and provides a potential therapeutic strategy for HCC by targeting the beta-TrCP/HLTF/p62/mTOR axis.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Oncology
Jiahui Li, Xiaolin Wu, Lars Schiffmann, Thomas MacVicar, Chenghui Zhou, Zhefang Wang, Dai Li, Oscar Velazquez Camacho, Reiner Heuchel, Margarete Odenthal, Axel Hillmer, Alexander Quaas, Yue Zhao, Christiane J. Bruns, Felix C. Popp
Summary: Pancreatic cancer, with the lowest survival rate among all malignancies, could potentially be targeted by inhibiting the IL-17B/IL-17RB signaling that accelerates tumor growth. This study reveals a metabolic cooperation between pancreatic stellate cells and tumor cells mediated by IL-17B signaling, leading to accelerated tumor growth.
Article
Biochemistry & Molecular Biology
Ronghang Hu, Baobin Xu, Jiajun Ma, Linfeng Li, Liming Zhang, Li Wang, Jiebo Zhu, Tao Guo, Heng Zhang, Shaoqiang Wang
Summary: LINC00963 is an oncogenic lncRNA that promotes the malignancy and metastasis of lung adenocarcinoma (LUAD) by stabilizing Zeb1 and inducing M2 macrophage polarization. Targeting LINC00963 could be a valuable therapeutic strategy for LUAD.
MOLECULAR MEDICINE
(2023)
Article
Oncology
Hyeseon Yun, Ji-Eun You, Jun Ki Hong, Do Yeon Kim, Ji-U Lee, Dong-Hee Kang, Yea Seong Ryu, Dong-In Koh, Dong-Hoon Jin
Summary: This study demonstrates a significant correlation between TCOF1 and beta-catenin in CRC, and suggests that stabilizing beta-catenin through regulating TCOF1 expression could be a potential therapeutic strategy for CRC.
Article
Oncology
Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying-Chyi Song, To-Jung Tseng, Chiung-Hui Liu
Summary: The upregulation of CHPF in breast cancer contributes to malignant behavior of cancer cells, promoting tumor growth and metastasis. Co-localization of tumor cell-derived G-CSF with CS on the cell surface was found. Breast cancer patients with high expression of both SDC4 and CHPF had worse overall survival, indicating synergistic effects of these two genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Zhaoyuan Hui, Yuanzheng Fu, Yunyun Chen, Jie Yin, Hui Fang, Yifan Tu, Ying Gu, Jiawei Zhang
Summary: TRIM24 inhibition promotes IL-10 expression and protects mice from endotoxic shock. This study provides new insights into the regulatory role of TRIM24 in IL-10 expression, making it a potentially attractive therapeutic target for inflammatory diseases.
INFLAMMATION RESEARCH
(2023)
Article
Cell Biology
Mengyuan Liu, Heming Li, Huijing Zhang, Huan Zhou, Taiwei Jiao, Mingliang Feng, Fangjian Na, Mingjun Sun, Mingfang Zhao, Lei Xue, Lu Xu
Summary: By analyzing high-throughput sequencing datasets, this study identified RBMS1 as a potential promoter gene for gastric cancer metastasis, which activates the JAK2/STAT3 signaling pathway and IL-6 transcriptional activation, promoting cell migration and invasion.
CELL DEATH & DISEASE
(2022)
Article
Anatomy & Morphology
Yi-Syue Tsou, Chih-Yang Wang, Ming-Yuan Chang, Tsung- Hsu, Meng-Ting Wu, Yi-Hsin Wu, Wan-Ling Tsai, Jian-Ying Chuang, Tzu-Jen Kao
Summary: Proper guidance of neuronal axons to their targets is crucial for neural circuit assembly during nervous system development, with Vav2 playing an essential role in motor axon pathfinding through interaction with the Src pathway and Netrin-1 regulation. Vav2 expression in LMC neurons is critical for the directional growth of axons, highlighting the importance of Vav proteins in mediating axonal trajectories.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Oncology
An-Chih Wu, Wen-Bin Yang, Kwang-Yu Chang, Jung-Shun Lee, Jing-Ping Liou, Ruei-Yuan Su, Siao Muk Cheng, Daw-Yang Hwang, Ushio Kikkawa, Tsung- Hsu, Chih-Yang Wang, Wen-Chang Chang, Pin-Yuan Chen, Jian-Ying Chuang
Summary: This study identifies LINC00461 as a significantly increased lncRNA in stem-like/treatment-resistant GBM cells, and demonstrates that targeting the HDAC6/RBP axis through LINC00461 can suppress GBM cell proliferation and prolong patient survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Neurosciences
Tzu-Jen Kao, Chih-Yang Wang, Tsung-I. Hsu, Yi-Hsin Wu, Jiang-Ying Chuang, Chi-Chen Huang, Cheng-Ta Hsieh
Summary: The study reveals the essential role of TDP-43 in axon guidance of spinal motor neurons and its regulation of EphB expression in mediating LMC pathfinding. These findings contribute to a better understanding of the mechanisms underlying neural circuit formation.
NEUROSCIENCE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yin-Hsun Feng, Sher-Wei Lim, Hong-Yi Lin, Shao-An Wang, Sung-Po Hsu, Tzu-Jen Kao, Chiung-Yuan Ko, Tsung- Hsu
Summary: Allopregnanolone (allo) has the potential to be a treatment for glioblastoma (GBM). It enhances the inhibitory effect of temozolomide (TMZ) on cell survival and proliferation, inhibits cell migration, and induces apoptosis. Allo also decreases the expression of DPYSL3/S100A11 and induces DNA damage to suppress GBM cell survival.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Clinical Neurology
I-Tsang Chiang, Yu-Chang Liu, Hua-Shan Liu, Ahmed Atef Ahmed Ali, Szu-Yi Chou, Tsung- Hsu, Fei-Ting Hsu
Summary: Our study found that regorafenib can enhance the efficacy of temozolomide against glioblastoma by inhibiting the CXCL12/CXCR4/ERK/NF-κB signaling pathway. Additionally, regorafenib can sensitize glioblastoma cells to temozolomide and reduce tumor size and prolong survival in animal models.
Article
Cell Biology
Hong-Yi Lin, Sher-Wei Lim, Tsung- Hsu, Wen-Bin Yang, Chi-Chen Huang, Yu-Ting Tsai, Wen-Chang Chang, Chiung-Yuan Ko
Summary: Cancer cells have increased and persistent oxidative stress due to reactive oxygen species (ROS) and stimulate the antioxidant system. However, overexpressed antioxidant enzymes can lead to drug resistance. In glioblastoma (GBM) cells, loss of the transcription factor CEBPD inhibits cell viability and accelerates intracellular accumulation of hydrogen peroxide (H2O2).
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Chie-Hong Wang, Hsuan-Cheng Wu, Chen-Wei Hsu, Yun-Wei Chang, Chiung-Yuan Ko, Tsung- Hsu, Jian-Ying Chuang, Tsui-Hwa Tseng, Shao-Ming Wang
Summary: The expression of MZF1 is elevated in GBM and is associated with a worse prognosis. CTD exhibits strong anti-proliferative effects on GBM cells by suppressing MZF1 expression. This study suggests that CTD may be a promising therapeutic agent for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wencan Zhang, Xu Cao, Xiancai Zhong, Hongmin Wu, Yun Shi, Mingye Feng, Yi-Chang Wang, David Ann, Yousang Gwack, Yate-Ching Yuan, Weirong Shang, Zuoming Sun
Summary: The study finds that the nuclear receptor coactivator SRC2 enhances CD4+ T cell activation by recruiting c-Myc and upregulating amino acid transporter Slc7a5, thereby stimulating immune responses. Mice deficient in SRC2 in T cells are resistant to EAE but susceptible to C. rodentium. SRC2fl/fl/CD4Cre mice display impaired T cell proliferation, cytokine production, and differentiation in vitro and in vivo. Therefore, SRC2 is essential for CD4+ T cell activation and could be a potential drug target for controlling CD4+ T cell-mediated autoimmunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Yi-Chang Wang, Andrew A. Kelso, Adak Karamafrooz, Yi-Hsuan Chen, Wei-Kai Chen, Chun-Ting Cheng, Yue Qi, Long Gu, Linda Malkas, Angelo Taglialatela, Hsing-Jien Kung, George-Lucian Moldovan, Alberto Ciccia, Jeremy M. Stark, David K. Ann
Summary: The dependence of cancer cells on arginine creates a vulnerability in metabolism. This study investigates how the availability of arginine affects DNA replication and resistance to genotoxicity. Through DNA combing assays, it is found that limiting extracellular arginine leads to the arrest of cancer cells and a slowdown in DNA replication. The translation of new histone H4 is arginine-dependent and influences DNA replication. Increased PCNA occupancy and HLTF-catalyzed PCNA K63-linked polyubiquitination protect arginine-starved cells from DNA damage. Arginine-deprived cancer cells display tolerance to genotoxicity in a PCNA K63-linked polyubiquitination-dependent manner. These findings emphasize the crucial role of extracellular arginine in nutrient-regulated DNA replication and provide potential avenues for cancer treatment development.
Review
Biochemistry & Molecular Biology
Hsien-Chung Chen, Wen-Chang Chang, Jian-Ying Chuang, Kwang-Yu Chang, Jing-Ping Liou, Tsung- Hsu
Summary: Eicosanoids are bioactive lipids derived from arachidonic acid in the brain, and they play diverse roles in normal physiology, including neuronal signaling, synaptic plasticity, and regulation of cerebral blood flow. Dysregulation of eicosanoids has been implicated in the development and progression of brain tumors, and understanding their role can inform the development of diagnostic, prognostic, and therapeutic approaches.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Chemistry, Medicinal
Hui-Ju Tseng, Suddhasatwa Banerjee, Bin Qian, Mei-Jung Lai, Tung-Yun Wu, Tsung- Hsu, Tony Eight Lin, Kai Cheng Hsu, Kuo-Hsiang Chuang, Jing-Ping Liou, Jean C. Shih
Summary: In this study, MAO A/HSP90 dual inhibitors were synthesized and found to be effective in inhibiting the growth of GBM and other cancers. These inhibitors showed activity against MAO A, HSP90 binding, and growth of both TMZ-sensitive and -resistant GBM cells. Additionally, they exhibited potential as immune checkpoint inhibitors by reducing IFN-gamma induced PD-L1 expression.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Tzu-Jen Kao, Chien-Liang Lin, Wen-Bin Yang, Hao-Yi Li, Tsung- Hsu
Summary: In this review, the researchers summarize current knowledge on lipid metabolism in GBM, specifically focusing on the development of TMZ resistance. Dysregulated lipid metabolism has been identified as a contributing factor to TMZ resistance in GBM, and targeting lipid metabolism may offer a promising approach for overcoming resistance and improving outcomes. The review highlights key metabolites and proteins involved in lipid synthesis, uptake, and utilization, as well as recent advances in metabolomics to study lipid metabolism in GBM.
LIPIDS IN HEALTH AND DISEASE
(2023)
Editorial Material
Oncology
Tsung- Hsu
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung, David K. Ann
Summary: This study identifies the role of eIF2 alpha O-GlcNAcylation in regulating antioxidant defense during arginine shortage. Eliminating eIF2 alpha O-GlcNAcylation improves cell recovery and migration, and reduces ROS accumulation by restoring HO-1 translation. These findings provide new insights into how arginine limitation fine-tunes translation control and antioxidant defense through eIF2 alpha O-GlcNAcylation, with potential biological and clinical implications.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Cell Biology
Yu-Ting Tsai, Wei-Lun Lo, Pin-Yuan Chen, Chiung-Yuan Ko, Jian-Ying Chuang, Tzu-Jen Kao, Wen-Bing Yang, Kwang-Yu Chang, Chia-Yang Hung, Ushio Kikkawa, Wen-Chang Chang, Tsung- Hsu
Summary: Sp1-regulated PGE2 production activates FAO and TCA cycle in mitochondria, resulting in TMZ resistance in GBM. These findings provide a new strategy to attenuate drug resistance or to re-sensitize recurrent GBM.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)