Review
Medicine, General & Internal
Menghua Zhou, Chaoqun Wang, Shounan Lu, Yanan Xu, Zihao Li, Hongchi Jiang, Yong Ma
Summary: Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary tract, with carcinogenesis associated with genomic and epigenetic abnormalities, as well as environmental effects. Tumor-associated macrophages (TAMs) in the tumor microenvironment interact closely with CCA cells by releasing protumor factors, promoting tumor growth, and exerting immunosuppressive and antichemotherapeutic effects. Targeting TAMs may offer insights into novel therapeutic approaches for CCA.
Review
Pharmacology & Pharmacy
Mahmoud S. Alghamri, Brandon L. McClellan, Margaret S. Hartlage, Santiago Haase, Syed Mohd Faisal, Rohit Thalla, Ali Dabaja, Kaushik Banerjee, Stephen V. Carney, Anzar A. Mujeeb, Michael R. Olin, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro
Summary: Gliomas, particularly glioblastomas, are highly aggressive and lethal cancers with unique molecular characteristics and genetic signatures. The interactions between tumor cells and immune cells in the tumor microenvironment play a critical role in glioma progression. Understanding the impact of inflammation and potential pharmacological interventions targeting neuro-inflammation are important for improving outcomes in glioma patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yuxiang Fan, Yubo Wang, Jian Zhang, Xuechao Dong, Pu Gao, Kai Liu, Chengyuan Ma, Gang Zhao
Summary: Despite advancements in tumorigenic comprehension and therapy, glioma remains a common and malignant brain tumor with features of recurrence, poor prognosis, and therapy resistance. Recent progress in immunotherapy for glioma shows promise, but efficacy varies among individuals, prompting exploration of immunity levels in the central nervous system and the immunosuppressive tumor immune microenvironment. Autophagy is highlighted as a key player in unraveling the relations between glioma and the tumor immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Teresa Ho, Rasha Msallam
Summary: Understanding the mechanisms of tumor immunosuppression is crucial for improving cancer immunotherapy. The rapid development of 3D organoid model systems provides a new approach for studying tumor immunosuppression. Developing patient-specific models is essential for investigating personalized immunotherapy.
Article
Immunology
Bo Li, Fang Wang, Nan Wang, Kuiyuan Hou, Jianyang Du
Summary: Angiogenesis in immunosuppressed low-grade gliomas is driven by m6A modification regulators and plays a role in mediating immunosuppression. This study investigated the relevance and mechanism of angiogenesis-related genes and m6A regulators, providing insights for the diagnosis and treatment of low-grade gliomas.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun-Jie Zhang, Yu Zhang, Qian Chen, Qi-Ning Chen, Xin Yang, Xiao-Lin Zhu, Chun-Yan Hao, Hu-Bin Duan
Summary: This study analyzed glioma samples using multiple methods and found that the immune microenvironment plays a vital role in glioma progression. Differential analysis and intersection with prognostic genes identified FCGBP as a key gene in glioma. Validation results showed that FCGBP expression increased and was up-regulated with the progression of glioma grade.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Stoyan Tankov, Paul R. Walker
Summary: Extracellular vesicles play a critical role in mediating communication between glioblastoma cells and immune cells, potentially impacting glioma progression by shaping the tumor microenvironment. These vesicles contain bioactive cargoes that can enhance glioma cell mediated immunosuppressive functions and reprogram tumor infiltrating immune cells, suggesting their importance in cancer-immune crosstalk and as potential diagnostic biomarkers for glioma.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Seiji Mabuchi, Tomoyuki Sasano
Summary: In uterine cervical and endometrial cancers, increased number of MDSCs is associated with advanced stage, poor survival, and resistance to chemotherapy or radiotherapy. Studies in murine models have shown the important roles of MDSCs in cancer progression. Treatment strategies targeting MDSCs may have growth-inhibitory effects and enhance the efficacy of existing anticancer treatments.
Article
Oncology
Zhen Fang, Fangen Kong, Jia Zeng, Zichen Zhang, Yunzhi Wang, Yiping Wang, Jiajia Duan, Lei Chen, Jikai Wang, Fei Liu
Summary: The overexpression of CNIH4 in malignant glioma is associated with adverse clinicopathological characteristics and poor prognosis. Silencing CNIH4 expression inhibits stem cell-like properties and tumorigenicity. CNIH4-enriched subgroup negatively modulates immunotherapeutic response and reflects lower chemotherapy sensitivity. CNIH4 could potentially serve as a prognostic factor and therapeutic target for glioma.
Article
Genetics & Heredity
Fengdong Yang, Xuezhi Zhang, Xinzhuang Wang, Yake Xue, Xianzhi Liu
Summary: This study investigated the expression of the newly discovered oncogene TMEM60 in glioma and its relationship with tumor characteristics. It was found that TMEM60 was significantly upregulated in glioma and associated with poor prognosis and changes in the tumor microenvironment. In addition, inhibiting TMEM60 expression weakened the proliferation and colony formation of glioma cells, suggesting that TMEM60 could be an effective therapeutic target for glioma.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Yuan Jiang, Qiankun Ji, Xiaoyan Long, Peng Wang, Zewei Tu, Xian Zhang, Xingen Zhu, Kai Huang, Jingying Li
Summary: The expression level of CLCF1 is related to the prognosis of glioma and is associated with the response to immunotherapy, suggesting that it may be a promising therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yi Xiao, Dihua Yu
Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Immunology
Lifei Liang, Xiaoqing Xu, Jiawei Li, Cheng Yang
Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yang Hu, Zhixing Li, Yichi Zhang, Yuzheng Wu, Zihao Liu, Jianhao Zeng, Zhexue Hao, Jin Li, Jiaoyan Ren, Maojin Yao
Summary: This review discusses the paradoxical roles of the tumor microenvironment (TME) in gliomas and provides an overview of recent advances in mouse models for studying the TME. Additionally, it summarizes the recent progress made in TME-targeting therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Immunology
Sarah Jaboury, Kenny Wang, Kim Maree O'Sullivan, Joshua Daniel Ooi, Gwo Yaw Ho
Summary: Neutrophil Extracellular Traps (NETs) are a form of pro-inflammatory cell death characterized by the release of DNA webs containing bactericidal enzymes. NETosis plays a role in autoimmune diseases and cancer, causing tissue damage and promoting tumor growth. This mini-review summarizes the interaction between neutrophils, particularly NETosis, and cancer cells, highlighting potential targets for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yanqiong Wu, Zeyong Yang, Shanchun Su, Xueqin Xu, Yang Li, Xiaohui Li, Yan Gao, Dongsheng Sun, Shengjun Wan, Mingjin Pen, Weiling Jin, Changbin Ke
Summary: This study reveals that repeated early-life exposure to anesthetics can disrupt neurodevelopment and affect social behaviors. The m6A modification plays a crucial role in this process, and anesthetics lead to persistent alterations in protein expression and brain function.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Ann T. Chen, Yang Xiao, Xiangjun Tang, Mehdi Baqri, Xingchun Gao, Melanie Reschke, Wendy C. Sheu, Gretchen Long, Yu Zhou, Gang Deng, Shenqi Zhang, Yanxiang Deng, Zhiliang Bai, Dongjoo Kim, Anita Huttner, Russell Kunes, Murat Gunel, Jennifer Moliterno, W. Mark Saltzman, Rong Fan, Jiangbing Zhou
Summary: This study investigates the invasion of glioblastoma (GBM) through the analysis of histological and single-cell RNA sequencing (scRNA-seq) data. The research reveals the cellular and molecular characteristics of invasive GBM, including lower cell density and proliferation rate compared to non-invasive GBM. Additionally, the study identifies the genes CRYAB and CD44 as important regulators of tumor invasion and highlights their relationship in invasive GBM.
Article
Biochemistry & Molecular Biology
Hualin Fu, Jilong Li, Peng Du, Weilin Jin, Guo Gao, Daxiang Cui
Summary: This study reveals that the formation of senile plaques is associated with the leakage of substances enriched with Aβ and Cathepsin D through blood.
Review
Biochemistry & Molecular Biology
Yan-Ting Li, Wen-Zhen Yuan, Wei-Lin Jin
Summary: This article summarizes the communication mechanisms between the vagus nerve and the gastrointestinal tumor microenvironment, and explores the potential and challenges of vagus nerve-based tumor neurotherapy in gastrointestinal tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Engineering, Biomedical
Yeying Wang, Yang Liu, Yi Liu, Jie Zhong, Jing Wang, Lei Sun, Lei Yu, Yiting Wang, Qinghua Li, Weilin Jin, Zhiqiang Yan
Summary: Liver cirrhosis is a liver disease with a high mortality rate worldwide. Antifibrotic drugs are commonly used clinically, but there are still many challenges. Excessive reactive oxygen species (ROS) in the liver lesions microenvironment is an important factor leading to the development of liver cirrhosis. Therefore, a nanomedicine-mediated antioxidant therapy can remodel the liver microenvironment and reverse the process of cirrhosis.
Article
Medicine, Research & Experimental
Chang Yang, Zhi-Qiang Wang, Zhao-Cong Zhang, Ge Lou, Wei-Lin Jin
Summary: The study found that CBL0137 induces apoptosis and pyroptosis in ovarian cancer cells by activating the reactive oxygen species pathway and regulating the BAX protein. In vivo experiments also demonstrated its anti-tumor effects on ovarian cancer cells. These findings suggest that CBL0137 could be a promising therapeutic agent for ovarian cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Cell Biology
Ming -Zhu Jin, Wei -Lin Jin
Summary: Recent work by Zhang et al. has developed an epigenome-transcriptome comapping technology that captures spatial epigenetic priming, differentiation, and gene regulation, revealing how epigenetic features influence cell dynamics and transcriptional phenotypes at spatial and genome-wide levels.
TRENDS IN CELL BIOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Ming-Zhu Jin, Xing-Chun Gao, Wei-Lin Jin
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Chuan Zhou, Yu-Qian Huang, Ming-Xu Da, Wei-Lin Jin, Feng-Hai Zhou
Summary: By 2035, more than 4 billion people might be affected by obesity and being overweight. Adipocyte-derived Extracellular Vesicles (ADEVs/ADEV-singular) play a crucial role in the communication between the tumor microenvironment and obesity, serving as a key mechanism of tumor progression. Obesity leads to hypertrophic and hyperplastic adipose tissue, causing insulin resistance and altering the energy supply to tumor cells, as well as promoting the production of pro-inflammatory adipokines. ADEVs are closely associated with cancer hallmarks and have the potential to be used as biomarkers and antitumor therapy. It is important to address the significant challenges and advances in ADEVs research and clinical applications.
Article
Medicine, Research & Experimental
Qian Zhang, Zi-Yi An, Wen Jiang, Wei-Lin Jin, Xin-Yang He
Summary: “Collagen, a major component of the extracellular matrix (ECM), plays a crucial role in tumor progression within the tumor microenvironment (TME). Recent studies have shown that collagen deposition in the TME affects tumor progression and interacts with tumor cells in complex ways. These findings highlight the potential of collagen as a target for cancer therapy.”
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Aman Khan, Shiqing Li, Huawen Han, Wei-Lin Jin, Zhenmin Ling, Jing Ji, Shazia Iram, Pu Liu, Sa Xiao, El-Sayed Salama, Xiangkai Li
Summary: The Bacillus subtilis LZU-GM strain isolated from fermented sourdough in Pakistan can degrade 73.7% of gluten in 24 hours in vitro. In mice models, the strain LZU-GM showed 3-fold higher gluten degradation in the small intestine compared to the untreated mice group. Furthermore, the strain LZU-GM improved the immune response in the lamina propria of the small intestine.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Haibo Tang, Tuoyu Zhou, Weilin Jin, Simin Zong, Tursunay Mamtimin, El-Sayed Salama, Byong-Hun Jeon, Pu Liu, Huawen Han, Xiangkai Li
Summary: This study aimed to construct a tumor-targeting engineered probiotic for colorectal cancer (CRC). The results showed that Azurin caused apoptosis in CT26 cells and Ep-AH treatment relieved symptoms in CRC mice and modulated the gut microbiota composition and metabolic pathways. This study provides an effective strategy for anti-CRC treatment.
Review
Biochemistry & Molecular Biology
Maifu Yu, Pin Sun, Changkai Sun, Wei-Lin Jin
Summary: Neurodegenerative diseases are common and difficult to treat, but cell therapy shows promise. Endogenous neural stem cells (eNSCs) have potential but are currently underexplored. This article compares stem cell transplantation with eNSC-based therapy and highlights the potential of combining eNSCs with developing technologies, such as bioelectronic medicine and biomaterials.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jing Ji, Weilin Jin, Shuang-Jiang Liu, Zuoyi Jiao, Xiangkai Li
Summary: The gut microbiota and its balance are crucial for human health. Traditional medicines can only relieve symptoms, and may even cause side effects. Probiotics, prebiotics, and postbiotics have shown potential in preventing and treating diseases, but are currently limited to being used as dietary supplements, hindering their application in medicine.
