Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications
出版年份 2019 全文链接
标题
Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications
作者
关键词
-
出版物
Cell Communication and Signaling
Volume 17, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-12-26
DOI
10.1186/s12964-019-0459-7
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tumor mutational load predicts survival after immunotherapy across multiple cancer types
- (2019) Robert M. Samstein et al. NATURE GENETICS
- Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma
- (2019) François Kuonen et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Misactivation of Hedgehog signaling causes inherited and sporadic cancers
- (2019) David R. Raleigh et al. JOURNAL OF CLINICAL INVESTIGATION
- FDA Approval Summary: Glasdegib for newly-diagnosed acute myeloid leukemia
- (2019) Kelly J. Norsworthy et al. CLINICAL CANCER RESEARCH
- Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation
- (2019) Eleftheria Papaioannou et al. JOURNAL OF CLINICAL INVESTIGATION
- Effective anti-programmed death-1 therapy in a SUFU -mutated patient with Gorlin-Goltz syndrome
- (2018) A. Moreira et al. BRITISH JOURNAL OF DERMATOLOGY
- Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
- (2018) Eamon FX Byrne et al. CURRENT OPINION IN CELL BIOLOGY
- Synergistic Cross-Talk of Hedgehog and Interleukin-6 Signaling Drives Growth of Basal Cell Carcinoma
- (2018) Christina Sternberg et al. INTERNATIONAL JOURNAL OF CANCER
- PD-L1 expression in medulloblastoma: an evaluation by subgroup
- (2018) Allison M. Martin et al. Oncotarget
- Anti-PD-1 Therapy Leads to Near-Complete Remission in a Patient with Metastatic Basal Cell Carcinoma
- (2018) Stefanie Fischer et al. Oncology Research and Treatment
- Pembrolizumab for advanced basal cell carcinoma: an investigator-initiated, proof-of-concept study
- (2018) Anne Lynn S. Chang et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
- (2018) Spencer C. Wei et al. Cancer Discovery
- Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer
- (2018) Tom Curran Open Biology
- Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome
- (2018) Jorge E. Cortes et al. LEUKEMIA
- Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer
- (2018) Jayati Chakrabarti et al. Oncotarget
- Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer
- (2018) Ann Hanna et al. OncoImmunology
- Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade
- (2017) Evan J. Lipson et al. Journal for ImmunoTherapy of Cancer
- Immunosuppressive Environment in Basal Cell Carcinoma: The Role of Regulatory T Cells
- (2016) S Omland et al. ACTA DERMATO-VENEREOLOGICA
- Hedgehog Pathway Inhibition
- (2016) Aleksandar Sekulic et al. CELL
- Disruption of the Hedgehog signaling pathway in inflammatory bowel disease fosters chronic intestinal inflammation
- (2016) Fernanda Buongusto et al. CLINICAL AND EXPERIMENTAL MEDICINE
- Schlafen 4–expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia
- (2016) Lin Ding et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of the hedgehog pathway in patients with basal-cell nevus syndrome: final results from the multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2016) Jean Y Tang et al. LANCET ONCOLOGY
- Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
- (2016) Ximena Bonilla et al. NATURE GENETICS
- Control of inflammation by stromal Hedgehog pathway activation restrains colitis
- (2016) John J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Primary Cilia and Mammalian Hedgehog Signaling
- (2016) Fiona Bangs et al. Cold Spring Harbor Perspectives in Biology
- Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
- (2016) Marco Gerling et al. Nature Communications
- Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma
- (2016) Yuqiong Wang et al. Journal of Cancer
- Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy
- (2016) Sadakatsu Ikeda et al. npj Genomic Medicine
- Mycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1- and prostaglandin E2-induced regulatory T cell expansion
- (2016) Sahana Holla et al. Scientific Reports
- Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
- (2015) Scott X. Atwood et al. CANCER CELL
- Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
- (2015) Hayley J. Sharpe et al. CANCER CELL
- RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors
- (2015) X. Zhao et al. CANCER RESEARCH
- Hedgehog Pathway Inhibitors Promote Adaptive Immune Responses in Basal Cell Carcinoma
- (2015) A. Otsuka et al. CLINICAL CANCER RESEARCH
- Topical treatment of basal cell carcinoma with the immune response modifier imiquimod
- (2015) Dimitrios Papakostas et al. Future Oncology
- The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NF B activity
- (2015) A. L. Furmanski et al. JOURNAL OF CELL SCIENCE
- Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial
- (2015) Michael R Migden et al. LANCET ONCOLOGY
- Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition
- (2015) Napapan Kangwan et al. Oncotarget
- Helicobacter pylori-induced Sonic Hedgehog Expression is Regulated by NFκB Pathway Activation: The Use of a Novel In vitro Model to Study Epithelial Response to Infection
- (2014) Michael A. Schumacher et al. HELICOBACTER
- Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma
- (2014) Tjinta Brinkhuizen et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
- (2014) Fritz Aberger et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Chronic Inflammation and Cytokines in the Tumor Microenvironment
- (2014) Glauben Landskron et al. Journal of Immunology Research
- Defective TGF-β Signaling in Bone Marrow–Derived Cells Prevents Hedgehog-Induced Skin Tumors
- (2013) Qipeng Fan et al. CANCER RESEARCH
- U.S. Food and Drug Administration Approval: Vismodegib for Recurrent, Locally Advanced, or Metastatic Basal Cell Carcinoma
- (2013) M. Axelson et al. CLINICAL CANCER RESEARCH
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
- (2013) Lisa D. Mills et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tissue-Derived Hedgehog Proteins Modulate Th Differentiation and Disease
- (2013) A. L. Furmanski et al. JOURNAL OF IMMUNOLOGY
- GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
- (2013) Scott X. Atwood et al. NATURE
- A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
- (2013) Taku Okazaki et al. NATURE IMMUNOLOGY
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation
- (2013) F Wolff et al. ONCOGENE
- Gli1 Deletion Prevents Helicobacter-Induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets
- (2013) Mohamad El-Zaatari et al. PLoS One
- Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse
- (2013) M. de la Roche et al. SCIENCE
- Molecular Pathways: The Hedgehog Signaling Pathway in Cancer
- (2012) R. McMillan et al. CLINICAL CANCER RESEARCH
- Gastric Sonic Hedgehog Acts as a Macrophage Chemoattractant During the Immune Response to Helicobacter pylori
- (2012) Michael A. Schumacher et al. GASTROENTEROLOGY
- A Role for Transcription Factor STAT3 Signaling in Oncogene Smoothened-driven Carcinogenesis
- (2012) Dongsheng Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
- (2012) Barbara Drobits et al. JOURNAL OF CLINICAL INVESTIGATION
- Basal cell carcinoma — molecular biology and potential new therapies
- (2012) Maria Kasper et al. JOURNAL OF CLINICAL INVESTIGATION
- Vismodegib
- (2012) Andrzej Dlugosz et al. NATURE REVIEWS DRUG DISCOVERY
- Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
- (2012) Jean Y. Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- GLI2 Regulates TGF-β1 in Human CD4+ T Cells: Implications in Cancer and HIV Pathogenesis
- (2012) Robert L. Furler et al. PLoS One
- Autocrine Sonic Hedgehog Attenuates Inflammation in Cerulein-Induced Acute Pancreatitis in Mice via Upregulation of IL-10
- (2012) Xiangyu Zhou et al. PLoS One
- Gli Proteins in Development and Disease
- (2011) Chi-chung Hui et al. Annual Review of Cell and Developmental Biology
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor
- (2011) Hans Skvara et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases
- (2011) A. Ruiz i Altaba Science Signaling
- Hedgehog beyond medulloblastoma and basal cell carcinoma
- (2010) Stephan Teglund et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Immunity, Inflammation, and Cancer
- (2010) Sergei I. Grivennikov et al. CELL
- Hedgehog Is an Anti-Inflammatory Epithelial Signal for the Intestinal Lamina Propria
- (2010) William J. Zacharias et al. GASTROENTEROLOGY
- Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis
- (2010) Qipeng Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
- (2010) Elspeth M. Beauchamp et al. JOURNAL OF CLINICAL INVESTIGATION
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
- (2010) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
- (2010) Monique T. Barakat et al. TRENDS IN MOLECULAR MEDICINE
- Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals
- (2010) B. Stecca et al. Journal of Molecular Cell Biology
- Hedgehog signalling in breast cancer
- (2009) M. Kasper et al. CARCINOGENESIS
- Imiquimod Enhances IFN-γ Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin
- (2009) Susan J. Huang et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
- Cancer-related inflammation
- (2008) Alberto Mantovani et al. NATURE
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