USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy

(2013) Yihui Fan et al.   APOPTOSIS

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

(2012) V. Pant et al.   BLOOD

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

(2012) Céline Reverdy et al.   CHEMISTRY & BIOLOGY

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7

(2012) Yingnan Zhang et al.   Nature Chemical Biology

Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma

(2011) Danielle M. Patterson et al.   ANGIOGENESIS

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise

(2011) A. Mandinova et al.   Science Translational Medicine

Immunology and immunotherapy of neuroblastoma

(2011) Robert C. Seeger   SEMINARS IN CANCER BIOLOGY

Genetically engineered murine models – Contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma

(2011) Louis Chesler et al.   SEMINARS IN CANCER BIOLOGY

Nutlin-3a Is a Potential Therapeutic for Ewing Sarcoma

(2010) K. I. Pishas et al.   CLINICAL CANCER RESEARCH

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

Inactivation of HAUSP in vivo modulates p53 function

(2009) N Kon et al.   ONCOGENE

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Targeting ubiquitin specific proteases for drug discovery

(2007) Laurent Daviet et al.   BIOCHIMIE