标题
Cathepsin D—Managing the Delicate Balance
作者
关键词
-
出版物
Pharmaceutics
Volume 13, Issue 6, Pages 837
出版商
MDPI AG
发表日期
2021-06-07
DOI
10.3390/pharmaceutics13060837
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy
- (2021) Magdalena Rudzińska et al. Drug Design Development and Therapy
- Identification of Cathepsin D as a Plasma Biomarker for Alzheimer’s Disease
- (2021) Jae-Whan Kim et al. Cells
- The noncanonical role of the protease cathepsin D as a cofilin phosphatase
- (2021) Yi-Jun Liu et al. CELL RESEARCH
- Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties
- (2021) Josina Bunk et al. Frontiers in Cell and Developmental Biology
- Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death
- (2021) Jialin Dai et al. BMC Cardiovascular Disorders
- Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis
- (2021) Hideaki Iwama et al. Scientific Reports
- A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis
- (2020) Jianping Wu et al. ANTI-CANCER DRUGS
- Elevated levels of BDNF and cathepsin‐ d as possible peripheral markers of neurodegeneration in plasma of patients with glutaric acidemia type I
- (2020) Gilian Guerreiro et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis
- (2020) Radka Houštecká et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neuroprotective Effects of Necrostatin-1 Against Oxidative Stress–Induced Cell Damage: an Involvement of Cathepsin D Inhibition
- (2020) Danuta Jantas et al. NEUROTOXICITY RESEARCH
- Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients
- (2020) Carlos Pomilio et al. GeroScience
- Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective
- (2020) M. Iqbal Hossain et al. Autophagy
- TBBPA regulates calcium-mediated lysosomal exocytosis and thereby promotes invasion and migration in hepatocellular carcinoma
- (2020) Liang Lyu et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Antiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non–Small Cell Lung Cancer through Inactivating ERK/CTSD Signalling Pathways
- (2020) Chien-Ming Liu et al. MOLECULES
- Chlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway
- (2020) Lijuan Gao et al. Drug Design Development and Therapy
- A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity
- (2020) Rüdiger Groß et al. Frontiers in Microbiology
- Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson’s Disease
- (2020) Ping Gan et al. Frontiers in Pharmacology
- Lysosomal Biology and Function: Modern View of Cellular Debris Bin
- (2020) Purvi C. Trivedi et al. Cells
- Redox-Mediated Post-Translational Modifications of Proteolytic Enzymes and Their Role in Protease Functioning
- (2020) Anastasiia I. Petushkova et al. Biomolecules
- Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β‐amyloid‐toxicity
- (2020) Y. Wang et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Cilostazol restores autophagy flux in bafilomycin A1-treated, cultured cortical astrocytes through lysosomal reacidification: roles of PKA, zinc and metallothionein 3
- (2020) Ha Na Kim et al. Scientific Reports
- Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D
- (2020) Sandeep Goyal et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson’s Disease
- (2020) Juhee Kang et al. CTS-Clinical and Translational Science
- Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling
- (2020) Mahendra Pal Singh et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer
- (2020) Surinder M. Soond et al. Cancers
- Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis
- (2020) Surinder M. Soond et al. Cancers
- The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium
- (2019) Zhigang Liang et al. Frontiers in Aging Neuroscience
- Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH
- (2019) Victoria J. Butler et al. JOURNAL OF MOLECULAR BIOLOGY
- Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
- (2019) Arshed Nazmi et al. GLIA
- Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro
- (2019) Victoria J. Butler et al. BIOCHEMISTRY
- Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
- (2019) André R. A. Marques et al. Autophagy
- Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors
- (2019) A. I. Petushkova et al. BIOCHEMISTRY-MOSCOW
- ‘Patchiness’ and basic cancer research: unravelling the proteases
- (2019) Surinder M Soond et al. CELL CYCLE
- The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
- (2019) Magdalena Rudzińska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors
- (2019) Anastasia V. Bagamanshina et al. Biomed Research International
- Identification of RNA aptamer which specifically interacts with PtdIns(3)P
- (2019) Thoria Donia et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Increased expression of cathepsin D is required for L1-mediated colon cancer progression
- (2019) Sayon Basu et al. Oncotarget
- Lost or Forgotten: The nuclear cathepsin protein isoforms in cancer
- (2019) Surinder M. Soond et al. CANCER LETTERS
- Autophagic- and Lysosomal-Related Biomarkers for Parkinson’s Disease: Lights and Shadows
- (2019) Helena Xicoy et al. Cells
- Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
- (2019) Akitoshi Nakashima et al. Autophagy
- Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal membrane injury and aberrant expression of cathepsin D
- (2019) Satoru Kobayashi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach
- (2019) Martijn F. Hoes et al. EUROPEAN JOURNAL OF HEART FAILURE
- Comprehensive Exploration of Target‐specific Ligands Using a Graph Convolution Neural Network
- (2019) Yu Miyazaki et al. Molecular Informatics
- A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease
- (2019) Elma Aflaki et al. NEUROBIOLOGY OF DISEASE
- Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation
- (2019) Shi-yu Yang et al. NEUROBIOLOGY OF DISEASE
- Differential quantitative proteomics reveals key proteins related to phenotypic changes of breast cancer cells expressing progesterone receptor A
- (2019) Prangwan Pateetin et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Cathepsins: Proteases that are vital for survival but can also be fatal
- (2018) Seema Patel et al. BIOMEDICINE & PHARMACOTHERAPY
- Emerging roles of microglial cathepsins in neurodegenerative disease
- (2018) Jessica R. Lowry et al. BRAIN RESEARCH BULLETIN
- Is digestive cathepsin D the rule in decapod crustaceans?
- (2018) Diana Martínez-Alarcón et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
- Hybrid 2D/3D-quantitative structure–activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors
- (2018) Olayide A Arodola et al. Future Medicinal Chemistry
- Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging
- (2018) Xinya Xu et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis
- (2018) Andrew E. Arrant et al. JOURNAL OF NEUROSCIENCE
- Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies
- (2018) Tim E. Moors et al. MOLECULAR NEUROBIOLOGY
- Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy
- (2018) Gina Puska et al. NEUROBIOLOGY OF DISEASE
- Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration
- (2018) Yuek Ling Chai et al. BRAIN PATHOLOGY
- Decreased Expression of Cathepsin D in Monocytes is Related to the Defective Degradation of Amyloid-β in Alzheimer's Disease
- (2018) Li Tian et al. JOURNAL OF ALZHEIMERS DISEASE
- An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect
- (2018) Yasir H. Qureshi et al. MOLECULAR AND CELLULAR BIOLOGY
- Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells
- (2018) N. Bannoud et al. PLoS One
- Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model
- (2018) Ping Gan et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Main Olfactory and Vomeronasal Epithelium Are Differently Affected in Niemann-Pick Disease Type C1
- (2018) Martin Witt et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer’s Disease and MCI Patients: Implications for Regenerative Medicine Approaches
- (2017) Francesco Morena et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis
- (2017) Ali A. Aghdassi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor
- (2017) Christopher R. Ellis et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Taking out the garbage: cathepsin D and calcineurin in neurodegeneration
- (2017) Sabrina Büttner et al. Neural Regeneration Research
- Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria – A proteomic study in an animal model of depression
- (2017) Katarzyna Głombik et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer
- (2017) Byung Moo Oh et al. Cell Death & Disease
- Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells
- (2017) Janja Završnik et al. Oncotarget
- The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity
- (2017) Andreas Aufschnaiter et al. Frontiers in Molecular Neuroscience
- Lysosomal adaptation: How cells respond to lysosomotropic compounds
- (2017) Shuyan Lu et al. PLoS One
- Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages
- (2017) Seoung-ryoung Choi et al. PLoS One
- The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders
- (2016) Chiara Vidoni et al. MEDICINAL RESEARCH REVIEWS
- Serum Markers of Neurodegeneration in Maple Syrup Urine Disease
- (2016) Giselli Scaini et al. MOLECULAR NEUROBIOLOGY
- Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease
- (2016) Carmela Matrone et al. PLoS One
- Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
- (2016) Pasquale Cocchiaro et al. Scientific Reports
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI
- (2015) Aylin Hatice Yamac et al. HERZ
- Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy
- (2015) Davor Ivankovic et al. JOURNAL OF NEUROCHEMISTRY
- Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence
- (2015) Siyuan Su et al. MOLECULAR & CELLULAR PROTEOMICS
- Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease
- (2015) Edward J. Goetzl et al. NEUROLOGY
- Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease
- (2015) F. Wu et al. NEUROSCIENCE
- Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
- (2015) Ryan P. McGlinchey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting
- (2015) Sandra Markmann et al. TRAFFIC
- Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria
- (2015) C S F Oliveira et al. Cell Death & Disease
- New Roles of Glycosaminoglycans in α-Synuclein Aggregation in a Cellular Model of Parkinson Disease
- (2015) Sonia Lehri-Boufala et al. PLoS One
- Structure-based optimization of non-peptidic Cathepsin D inhibitors
- (2014) Ulrich Grädler et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology
- (2014) J. Hersheson et al. NEUROLOGY
- Cysteine Cathepsin Activity Regulation by Glycosaminoglycans
- (2014) Marko Novinec et al. Biomed Research International
- A model of lysosomal pH regulation
- (2013) Yoichi Ishida et al. JOURNAL OF GENERAL PHYSIOLOGY
- Cysteine Cathepsins in Neurological Disorders
- (2013) Anja Pišlar et al. MOLECULAR NEUROBIOLOGY
- Role of Cathepsin D in U18666A-induced Neuronal Cell Death
- (2012) Asha Amritraj et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish
- (2011) Carlo Follo et al. PLoS One
- Regulation of apoptosis-associated lysosomal membrane permeabilization
- (2010) Ann-Charlotte Johansson et al. APOPTOSIS
- Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes
- (2010) C Oberle et al. CELL DEATH AND DIFFERENTIATION
- Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain
- (2009) Aino-Liisa Mutka et al. JOURNAL OF NEUROCHEMISTRY
- Cerebrospinal fluid β-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies
- (2009) L. Parnetti et al. NEUROBIOLOGY OF DISEASE
- Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10)
- (2008) Karen Fritchie et al. ACTA NEUROPATHOLOGICA
- Cathepsin D: A cellular roadmap
- (2008) Nousheen Zaidi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†
- (2008) Daniel Sevlever et al. BIOCHEMISTRY
- Principles of lysosomal membrane degradation
- (2008) Heike Schulze et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Thrombin Up-regulates Cathepsin D which Enhances Angiogenesis, Growth, and Metastasis
- (2008) L. Hu et al. CANCER RESEARCH
- Cathepsin D—Many functions of one aspartic protease
- (2008) Petr Benes et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
- (2008) Anna Moles et al. HEPATOLOGY
- Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
- (2008) Liyan Qiao et al. Molecular Brain
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