Cysteine Cathepsins in Neurological Disorders

Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X

(2013) Anja Hafner et al.   AGING CELL

Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells

(2013) Anja Hafner Pišlar et al.   NEUROPHARMACOLOGY

Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells

(2012) Špela Magister et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system

(2012) Masato Koike et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease

(2012) Suraj Pradhan et al.   EXPERIMENTAL NEUROLOGY

Human Cathepsin V Protease Participates in Production of Enkephalin and NPY Neuropeptide Neurotransmitters

(2012) Lydiane Funkelstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters

(2012) Weiya Douglas Lu et al.   JOURNAL OF NEUROCHEMISTRY

Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation

(2012) Kai Fan et al.   Journal of Neuroinflammation

Human stefin B normal and patho-physiological role: molecular and cellular aspects of amyloid-type aggregation of certain EPM1 mutants

(2012) Mira Polajnar et al.   Frontiers in Molecular Neuroscience

Brain cathepsin B cleaves a caspase substrate

(2011) A. A. Yakovlev et al.   BIOCHEMISTRY-MOSCOW

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

(2011) Vivian Hook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer’s disease

(2011) Israel Schechter et al.   BIOLOGICAL CHEMISTRY

Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells

(2011) Bei Xiang et al.   BRAIN RESEARCH

Cysteine Proteases Bleomycin Hydrolase and Cathepsin Z Mediate N-terminal Proteolysis and Toxicity of Mutant Huntingtin

(2011) Tamara Ratovitski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

(2011) Qiuli Liang et al.   Molecular Neurodegeneration

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy

(2010) Gurjinder Kaur et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Cystatin C in Neuroprotection and Its Therapeutic Implications

(2010) Luciano D'Adamio   AMERICAN JOURNAL OF PATHOLOGY

Cystatins – Extra- and intracellular cysteine protease inhibitors: High-level secretion and uptake of cystatin C in human neuroblastoma cells

(2010) Hanna Wallin et al.   BIOCHIMIE

Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease

(2010) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus

(2010) Grzegorz A. Czapski et al.   BRAIN RESEARCH

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides

(2010) Lydiane Funkelstein et al.   NEUROPEPTIDES

Parkinson's disease involves autophagy and abnormal distribution of cathepsin L

(2010) Lingyun Li et al.   NEUROSCIENCE LETTERS

Cystatin C: A Candidate Biomarker for Amyotrophic Lateral Sclerosis

(2010) Meghan E. Wilson et al.   PLoS One

Friends and relations of the cystatin superfamily-new members and their evolution

(2010) W.M. Brown et al.   PROTEIN SCIENCE

The role of cathepsin X in cell signaling

(2010) Janko Kos et al.   Cell Adhesion & Migration

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

(2009) Tamas Revesz et al.   ACTA NEUROPATHOLOGICA

Increased Activity and Altered Subcellular Distribution of Lysosomal Enzymes Determine Neuronal Vulnerability in Niemann-Pick Type C1-Deficient Mice

(2009) Asha Amritraj et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

(2009) Vivian Y.H. Hook et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diverse regulatory roles for lysosomal proteases in the immune response

(2009) Jeff D. Colbert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

(2009) Nataša Obermajer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model

(2009) Wiebke Wendt et al.   JOURNAL OF NEUROCHEMISTRY

Trypsin-specific inhibitors from the basidiomycete Clitocybe nebularis with regulatory and defensive functions

(2009) P. Avanzo et al.   MICROBIOLOGY-SGM

The role of lysosomal rupture in neuronal death

(2009) Tetsumori Yamashima et al.   PROGRESS IN NEUROBIOLOGY

Cathepsins: Key modulators of cell death and inflammatory responses

(2008) Sébastien Conus et al.   BIOCHEMICAL PHARMACOLOGY

Upregulation of cathepsin S in the aging and pathological nervous system of mice

(2008) Wiebke Wendt et al.   BRAIN RESEARCH

New Insights into the Roles of Endolysosomal Cathepsins in the Pathogenesis of Alzheimers Disease: Cathepsin Inhibitors as Potential Therapeutics

(2008) Azizul Haque et al.   CNS & Neurological Disorders-Drug Targets

Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation

(2008) Nicolas Fissolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression

(2008) Lydiane Funkelstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression

(2008) Lydiane Funkelstein et al.   JOURNAL OF NEUROCHEMISTRY

Serum cystatin C and the risk of Alzheimer disease in elderly men

(2008) J. Sundelof et al.   NEUROLOGY

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON

The roles of the proteasome pathway in signal transduction and neurodegenerative diseases

(2008) Jiao-Jiao Chen et al.   Neuroscience Bulletin

Cysteine cathepsins: Cellular roadmap to different functions

(2007) Klaudia Brix et al.   BIOCHIMIE