Review
Biotechnology & Applied Microbiology
Ve Van Le, Quynh-Giao Tran, So-Ra Ko, Sang-Ah Lee, Hee-Mock Oh, Hee-Sik Kim, Chi-Yong Ahn
Summary: This review summarizes the effects of antibiotic pollution on freshwater microalgae and cyanobacteria, focusing on major biological processes such as photosynthesis, oxidative stress, and macromolecule metabolism. Adaptive mechanisms and antibiotic removal pathways by these organisms are also discussed.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ranjan Mishra, Nicolas Minc, Matthias Peter
Summary: This article reviews the types and origins of mechanical forces experienced by unicellular yeast, as well as how these forces affect cell polarity and the invasion mechanism of pathogenic fungi. Additionally, the article discusses the common force-sensing mechanisms and downstream mechanotransduction mechanisms.
TRENDS IN MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Laura Marongiu, Mihai Valache, Fabio A. Facchini, Francesca Granucci
Summary: Dendritic cells play a crucial role in antiviral immunity by sensing viral pathogens and coordinating immune responses. Different subsets of DCs have complementary functions during viral infections, with a particular focus on their interaction with SARS-CoV-2. Although DC-mediated antiviral responses often lead to the production of proinflammatory cytokines and activation of adaptive immunity, the migratory properties of DCs can also contribute to further viral dissemination.
Review
Cell Biology
Xuexia Tian, Anhua Shi, Hang Yin, Yutian Wang, Qiaoyan Liu, Wenling Chen, Junzi Wu
Summary: The safety and efficacy of tumor treatment are challenging issues. Lysosomes have emerged as important targets in tumor treatment due to their unique environment and function. Nanoparticles, with their distinct physicochemical properties, offer significant advantages in tumor research. Thus, researchers have been designing various types of nanoparticles in recent years to treat tumors based on lysosomal function and environment. This review summarizes and analyzes different perspectives on tumor treatment, including lysosomal destruction/escape, drug delivery by nanoparticles, response to internal/external stimuli, and targeting of tumor cells or other cells. The advantages, disadvantages, and future prospects of these approaches are discussed, aiming to provide new insights for improved tumor treatment.
Review
Oncology
HyeonJoo Cheon, Yuxin Wang, Samantha M. Wightman, Mark W. Jackson, George R. Stark
Summary: Acute exposure to high concentrations of IFN-I leads to growth arrest and apoptosis in cancer cells, while chronic exposure to low concentrations provides prosurvival advantages. Phosphorylated ISGF3 drives acute deleterious responses to IFN-I, while unphosphorylated ISGF3 drives essential constitutive prosurvival mechanisms. PD-L1, known for its role in inactivating cytotoxic T cells, also has cell-intrinsic protumor activities, including dampening acute responses to high levels of IFN-I and sustaining expression at low levels that benefit tumors. Understanding the complex roles of IFN-I in cancer may lead to new therapeutic strategies.
Review
Plant Sciences
Kevin Daniel, Sjon Hartman
Summary: Plant submergence is a major abiotic stress that can be mitigated by changes in root growth behavior and adaptation to low oxygen conditions. Ethylene and hypoxia signaling play important roles in regulating these adaptive root growth responses. Future research should focus on more natural experimental designs to better understand how plants respond to and survive waterlogging.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Microbiology
E. B. Gareth Jones, Sundari Ramakrishna, Sabaratnam Vikineswary, Diptosh Das, Ali H. Bahkali, Sheng-Yu Guo, Ka-Lai Pang
Summary: This review explores the response mechanisms of marine fungi and fungal-like organisms to salinity variations, and reveals that marine fungi have a greater capacity to adapt to higher salinities compared to terrestrial and freshwater fungi. They require a range of physiological and genetic characteristics to respond to the challenges brought by climate change.
Article
Business
Paola Zanella, Paola Cillo, Gianmario Verona
Summary: This study analyzes the impact of information regime change induced by streaming on the music industry in the United States. The study finds that the inclusion of streaming increases demand for novelty and variety, and incumbents with higher breadth of experience perform better.
STRATEGIC MANAGEMENT JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Ke-Jia Wu, Chun Wu, Feng Chen, Sha-Sha Cheng, Dik-Lung Ma, Chung-Hang Leung
Summary: Lysosomes are membrane-bound organelles responsible for protein degradation and organelle recycling. By introducing an imidazole group and developing time-resolved emission spectroscopy, researchers successfully developed a high-throughput screening platform for discovering potential lysosomotropic drugs.
Editorial Material
Cell Biology
Keisuke Tabata, Marika Saeki, Tamotsu Yoshimori, Maho Hamasaki
Summary: Macroautophagy, or autophagy, is a highly conserved cellular degradation system that maintains cellular homeostasis. This study identified a new E3 ligase complex, involving CUL4A, as a regulatory complex in lysophagy, the process of targeting damaged lysosomes through autophagy. The complex was found to mediate a critical protein modification on LAMP2 during lysosomal damage, leading to the clearance of damaged lysosomes.
Article
Ecology
Ruxandra Popovici, Andre G. de L. Moraes, Zhao Ma, Laura Zanotti, Keith A. Cherkauer, Anna E. Erwin, Katy E. Mazer, Edwin F. Bocardo Delgado, Jose P. Pinto Caceres, Pranay Ranjan, Linda S. Prokopy
Summary: Climate change has impacted the indigenous and local knowledge held by crop farmers in Peru's Colca Valley, making it less effective in guiding crop planting and irrigation practices in the face of uncertainty and changes. Addressing the changing and uncertain indigenous and local knowledge poses challenges for local resource users who require long-term institution building for adaptation strategies.
ECOLOGY AND SOCIETY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Bernd Pulverer
Summary: The unprovoked war on Ukraine has shocked the global scientific community, including Russia. We need to persuade the Kremlin to return to a rules-based international order, while supporting Ukraine and Russian scientists facing sanctions.
Article
Green & Sustainable Science & Technology
Amol Kamalakar Bhalerao, Livia Rasche, Juergen Scheffran, Uwe A. Schneider
Summary: India's monsoon dependent agriculture is vulnerable to climate change, with most farmers in the Northeastern Region perceiving its impacts. Strategic interventions and holistic support programs are needed to raise awareness and facilitate farm adaptations.
INTERNATIONAL JOURNAL OF SUSTAINABLE DEVELOPMENT AND WORLD ECOLOGY
(2022)
Article
Chemistry, Medicinal
Anastasiya S. Sokolova, Olga I. Yarovaya, Oleg I. Artyushin, Elena V. Sharova, Dmitriy S. Baev, Ekaterina D. Mordvinova, Dmitriy N. Shcherbakov, Tatiana A. Shnaider, Tatiana V. Nikitina, Iana L. Esaulkova, Polina A. Ilyina, Vladimir V. Zarubaev, Valery K. Brel, Tatyana G. Tolstikova, Nariman F. Salakhutdinov
Summary: A new series of heterocyclic derivatives with a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment were designed, synthesised and biologically evaluated. These derivatives showed antiviral activity against Marburg and Ebola pseudotype viruses, and their activities were closely related to their lysosomotropic effect.
ARCHIV DER PHARMAZIE
(2023)
Article
Environmental Sciences
Yongqi Guo, Han Meng, Sichuan Zhao, Zixuan Wang, Lin Zhu, Dailan Deng, Jine Liu, Huan He, Wenming Xie, Guoxiang Wang, Limin Zhang
Summary: Cyanobacteria, including Microcystis aeruginosa, are widely present in freshwater ecosystems and can produce harmful toxins. This study investigated the effects of temperature on the life cycle and physiology of M. aeruginosa. The results showed that M. aeruginosa could recover from overwintering at low temperatures and recruit at higher temperatures. The optimal temperature for its growth and toxin secretion was found to be around 20-25 degrees Celsius. These findings suggest that global warming could promote the growth and toxicity of M. aeruginosa blooms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)