Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Knockdown of nucleoredoxin (NXN) in neuronal cells leads to increased proliferation, elevated basal respiratory rates, and a similar relative change in oxygen consumption compared to control cells under mitochondrial stressors. Moreover, NXN-deficient cells show increased expression of redox-sensitive heat shock proteins and autophagy markers, indicating higher levels of self-renewal and autophagy.
Article
Pharmacology & Pharmacy
Zahra Madadi, Shiva Akbari-Birgani, Saeed Mohammadi, Mitra Khademy, Seyed Asadollah Mousavi
Summary: Neuroblastoma is a common malignant tumor in infants and young children, with differentiation-inducing potential. The activation of caspase-9 plays a crucial role in the differentiation process of human neuroblastoma cells, promoting a change in cell morphology and protein expression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Yin-Sir Chung, Pervaiz Khalid Ahmed, Iekhsan Othman, Mohd. Farooq Shaikh
Summary: The study demonstrated the neuroprotective potential of Orthosiphon stamineus leaf proteins (OSLPs) in SH-SY5Y cells challenged by hydrogen peroxide. OSLPs were found to be safe and significantly increased cell survival and improved cell architecture in a concentration-dependent manner. OSLPs may exert their neuroprotective effects through modulating interleukin-4 and interleukin-13 pathways, regulating inflammation, and modulating HSP-regulated estrogen receptor pathways to counteract cellular damage induced by heat shock proteins under stress conditions.
Article
Chemistry, Medicinal
Gabriel Gonzalez, Jiri Hodon, Anna Kazakova, Cosimo Walter D'Acunto, Petr Kanovsky, Milan Urban, Miroslav Strnad
Summary: Novel triterpene derivatives showed potent neuroprotective effects in models of neurodegeneration, but also exhibited cytotoxicity at higher concentrations. These compounds modulated oxidative stress and apoptosis activity, with some derivatives demonstrating superior neuroprotective effects compared to traditional inhibitors.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Qi Qi Pang, Ji Hyun Kim, Hyun Young Kim, Ji-Hyun Kim, Eun Ju Cho
Summary: This study investigates the protective effects and mechanisms of pectolinarin against oxidative stress-induced cell damage in SH-SY5Y cells. Pectolinarin scavenges hydroxyl and nitric oxide radicals, increases cell viability, and reduces ROS production and LDH release. It also recovers protein expression of components involved in oxidative stress, inflammation, and apoptosis pathways.
Article
Biochemistry & Molecular Biology
Chao-Hsuan Chen, Pei-Chen Hsu, Shih-Wei Hsu, Kun-Ting Hong, Kai-Yuan Chen, Jie-Long He, Der-Yang Cho, Yun-Chi Wang, Wen-Shin Chang, Da-Tian Bau, Chia-Wen Tsai
Summary: Jujuboside A and B can protect neurons from 6-OHDA-induced toxicity by rebalancing the redox system and resetting the PI3K/AKT apoptotic signaling cascade.
Article
Chemistry, Medicinal
Xing Xing Zheng, Ying Chun Li, Kai Lin Yang, Zhou Xiao He, Zhao Liang Wang, Xing Wang, Hui Ling Jing, Yan Jun Cao
Summary: Icariin demonstrated protective effects against Glu-induced excitatory neurotoxicity, enhancing cell viability and reducing apoptosis, oxidative stress, and other negative impacts. These findings suggest that Icariin could be a potential therapeutic candidate for neurological disorders associated with glutamate toxicity.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Cristine Hepp Rehfeldt, Stefan Laufer, Marcia Ines Goettert
Summary: Current treatments for neurodegenerative diseases are limited in slowing down disease progression. This research evaluates the neuroprotective, anti-inflammatory, and antioxidant effects of a synthetic compound with JNK3 inhibitory activity in neuroblastoma cells, showing promising results in reducing cell damage and inflammation. This compound could be a potential candidate for treating neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nor Hafiza Sayuti, Nabilah Zulkefli, Jen Kit Tan, Norazalina Saad, Syarul Nataqain Baharum, Hamizah Shahirah Hamezah, Hamidun Bunawan, Qamar Uddin Ahmed, Humaira Parveen, Sayeed Mukhtar, Meshari A. Alsharif, Murni Nazira Sarian
Summary: This study found that PMEE can provide neuroprotection against H2O2-induced oxidative stress by activating multiple signaling pathways, and PMEE may serve as a preventative therapy for neurodegenerative diseases.
Article
Chemistry, Medicinal
Ha-Rin Moon, Jung-Mi Yun
Summary: Oxidative stress is a major factor in cell damage and neurodegenerative diseases, and zerumbone, a compound found in Zingiber zerumbet Smith essential oil, has various physiological activities including anticancer, antioxidant, and antibacterial effects. However, there is a lack of studies on the neuroprotective efficacy of zerumbone and its mechanism. This study explores the neuroprotective effects of zerumbone on hydrogen peroxide-treated human neuroblastoma cells and its underlying mechanism.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Biochemistry & Molecular Biology
Weishun Tian, Suyoung Heo, Dae-Woon Kim, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Myung-Kon Kim, Byung-Yong Park
Summary: Maclura tricuspidata fruit has protective effects against H2O2-induced oxidative damage in SH-SY5Y cells, showing potential for prevention and protection against neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Parkyong Song, Seo Young Choi, Ji Sun Hwang, Hyeon Cheal Park, Keun Ki Kim, Hong-Joo Son, Chang-Oh Hong, Yu-Jin Kim, Wanil Kim, Kwang Min Lee
Summary: This study found that Chrysanthemum boreale Makino extract (CBME) effectively suppresses oxidative stress-induced neurotoxicity in SH-SY5Y cells through multiple molecular mechanisms, providing evidence for its neuroprotective properties.
Article
Biochemistry & Molecular Biology
Mariarosaria Conte, Rosanna Palumbo, Alessandra Monti, Elisabetta Fontana, Angela Nebbioso, Menotti Ruvo, Lucia Altucci, Nunzianna Doti
Summary: The AIF/CypA complex has lethal activity in rodent models of acute brain injury, but an AIF peptide has been found to restore cell survival and prevent brain injury. This study shows that the peptide can also protect against apoptosis in PD cells, suggesting the AIF/CypA complex as a potential target for developing new PD therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Emiliano Bedini, Alfonso Iadonisi, Chiara Schiraldi, Laura Colombo, Diego Albani, Paola Petrini, Carmen Giordano, Marta Tunesi
Summary: Chondroitin sulfates (CS) are sulfated glycosaminoglycans with protective effects against neurodegenerative diseases like Alzheimer's. Research shows that the sulfation pattern of CS not only affects neuroprotection, but also drug release.
Article
Chemistry, Multidisciplinary
Nopparat Suthprasertporn, Nirut Suwanna, Wipawan Thangnipon
Summary: The study shows that DPN, an antioxidant selective agonist of estrogen receptor beta, can protect neuroblastoma cells from oxidative stress by attenuating various pathways involved in cell damage, indicating its potential in ameliorating neurodegenerative disorders.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kamila Kwiecien, Aneta Zegar, James Jung, Piotr Brzoza, Mateusz Kwitniewski, Urszula Godlewska, Beata Grygier, Patrycja Kwiecinska, Agnieszka Morytko, Joanna Cichy
CYTOKINE & GROWTH FACTOR REVIEWS
(2019)
Article
Materials Science, Multidisciplinary
Aneta Fraczek-Szczypta, Danuta Jantas, Filip Ciepiela, Justyna Grzonka
DIAMOND AND RELATED MATERIALS
(2020)
Article
Biochemistry & Molecular Biology
Mateusz Wawro, Jakub Kochan, Weronika Sowinska, Aleksandra Solecka, Karolina Wawro, Agnieszka Morytko, Patrycja Kwiecinska, Beata Grygier, Mateusz Kwitniewski, Mingui Fu, Joanna Cichy, Aneta Kasza
Summary: Members of the ZC3H12/MCPIP/Regnase RNase family play crucial roles in regulating inflammation, with Reg-3 showing distinct features such as substrate specificity and regulation of TNF transcript levels compared to other family members. In psoriasis, Reg-3 levels in the epidermis appear to be negatively regulated by Reg-1, suggesting reciprocal regulation between the two in disease pathophysiology. Both Reg-1 and Reg-3 are implicated in psoriasis by controlling different transcripts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Danuta Jantas, Janusz Malarz, Thanh Nguyen Le, Anna Stojakowska
Summary: Flavonols, such as kaempferitrin and alpha-rhamnoisorobin, have shown neuroprotective effects in vitro experiments on SH-SY5Y cells damaged by H2O2 and 6-OHDA. The tested flavonols were not effective in counteracting doxorubicin-induced cytotoxicity. Inhibition of the PI3-K/Akt pathway abolished the neuroprotective effect of the investigated flavonols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Agnieszka Wasik, Magdalena Bialon, Danuta Jantas, Marcelina Zarnowska
Summary: The combination treatment of MK-801 and 1MeTIQ has significant effects on cell viability, antioxidant enzyme activity, and glutamate release in the rat hippocampus. 1MeTIQ partially mitigates cell death induced by MK-801; coadministration of MK-801 and 1MeTIQ restores antioxidant enzyme activity levels compared to monotherapy.
NEUROTOXICITY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Danuta Jantas, Wladyslaw Lason
Summary: Neurodegenerative diseases are common chronic conditions without definitive treatment. Oxidative stress and necroptosis are thought to be closely related to the pathogenesis of neurodegenerative diseases. Multi-potential neuroprotectants with antioxidant and anti-necroptotic properties may be an effective therapeutic strategy.
Article
Food Science & Technology
Marta Ceglowska, Karolina Szubert, Beata Grygier, Marzena Lenart, Jacek Plewka, Aleksandra Milewska, Kinga Lis, Artur Szczepanski, Yuliya Chykunova, Emilia Barreto-Duran, Krzysztof Pyrc, Alicja Kosakowska, Hanna Mazur-Marzec
Summary: Even cyanobacteria from low biodiversity ecosystems have been found to contain bioactive metabolites with potent activities. In this study, various tests were conducted to evaluate the activity of the strain Pseudanabaena galeata CCNP1313, and it was found to exhibit cytotoxic and antiviral effects. However, the isolated compounds showed minor effects, highlighting the challenges in attributing observed biological effects to specific metabolites produced in minute amounts.
Review
Biochemistry & Molecular Biology
Wladyslaw Lason, Danuta Jantas, Monika Leskiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Summary: Ischemic stroke is a major cause of death and disability worldwide. In this context, vitamin D3 has emerged as a potential treatment adjunct, with its ability to interfere with key prosurvival pathways and show neuroprotective, anti-inflammatory, regenerative, and anti-aging properties. This narrative review discusses the biochemical mechanisms of stroke-related brain damage, the effects of vitamin D3 on diverse cell death signaling pathways, and the outcomes of experimental and clinical studies on its neuroprotective potential in ischemic stroke.
Review
Cell Biology
Wladyslaw Lason, Danuta Jantas, Monika Leskiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Summary: The vitamin D receptor (VDR) is a nuclear receptor superfamily of transcription factors involved in neuroprotective, antiaging, prosurvival, and anti-inflammatory actions of vitamin D. The relationship between vitamin D insufficiency and susceptibility to neurodegenerative diseases has been suggested, but the role of VDR in brain pathologies remains unclear due to the multitargeted mechanisms of vitamin D.
Article
Immunology
Patrycja Kwiecinska, Mateusz Kwitniewski, Kamila Kwiecien, Agnieszka Morytko, Pawel Majewski, Natalia Pocalun, Maciej Pastuszczak, Marcin Migaczewski, Joanna Cichy, Beata Grygier
Summary: This study investigated the role of secretory leukocyte protease inhibitor (SLPI) in mast cell-dependent processes and found that SLPI inhibits the activity of chymase in mast cells and enhances their degranulation. The study also showed that SLPI is expressed in dermal mast cells of patients with psoriasis. These findings reveal previously unknown mechanisms underlying FceRI and Mrgprb2-dependent mast cell function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Rugmani Meenambal, Tomasz Kruk, Jacek Gurgul, Piotr Warszynski, Danuta Jantas
Summary: In this study, PAA-CeO nanoparticles were synthesized and found to have neuroprotective effects against cell damage induced by H2O2 and 6-OHDA, reducing necrotic changes and partially attenuating caspase-3 activity. However, there was no impact on ROS formation induced by H2O2.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Aneta Fraczek-Szczypta, Natalia Kondracka, Marcel Zambrzycki, Maciej Gubernat, Pawel Czaja, Miroslawa Pawlyta, Piotr Jelen, Ryszard Wielowski, Danuta Jantas
Summary: The goal of this study was to develop electrode materials for nerve tissue stimulation using carbon-carbon composites with a core of carbon fibers and a pyrolytic carbon matrix. The materials were characterized using various techniques to evaluate their microstructural, chemical, and surface properties, and their biocompatibility was assessed using a neuroblastoma cell line.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Danuta Jantas, Jakub Chwastek, Janusz Malarz, Anna Stojakowska, Wladyslaw Lason