标题
Functional Roles of Bromodomain Proteins in Cancer
作者
关键词
-
出版物
Cancers
Volume 13, Issue 14, Pages 3606
出版商
MDPI AG
发表日期
2021-07-19
DOI
10.3390/cancers13143606
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Clinical perspectives of BET inhibition in ovarian cancer
- (2021) Angeliki Andrikopoulou et al. CELLULAR ONCOLOGY
- Overexpression of the TRIM24 E3 Ubiquitin Ligase is Linked to Genetic Instability and Predicts Unfavorable Prognosis in Prostate Cancer
- (2021) Doris Höflmayer et al. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
- Dysregulation of Wnt/β‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application
- (2021) Qian Li et al. CANCER SCIENCE
- Regulation of ZMYND8 to Treat Cancer
- (2021) Yun Chen et al. MOLECULES
- Discovery and characterization of bromodomain 2–specific inhibitors of BRDT
- (2021) Zhifeng Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor–activated cancer
- (2021) Bo Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Fate of Speckled Protein 100 (Sp100) During Herpesviruses Infection
- (2021) Mila Collados Rodríguez Frontiers in Cellular and Infection Microbiology
- BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes
- (2021) Shuiyan Wu et al. Cancer Cell International
- Precision Oncology via NMR-Based Metabolomics: A Review on Breast Cancer
- (2021) Alessia Vignoli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Preventing Breast Cancer Through Identification and Pharmacologic Management of High-Risk Patients
- (2021) Elizabeth A. Gilman et al. MAYO CLINIC PROCEEDINGS
- Intratumoral Cellular Heterogeneity: Implications for Drug Resistance in Patients with Non-Small Cell Lung Cancer
- (2021) Vanesa Gregorc et al. Cancers
- CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer
- (2021) Laia Castells-Roca et al. Cancers
- Intratumoral Heterogeneity in Differentiated Thyroid Tumors: An Intriguing Reappraisal in the Era of Personalized Medicine
- (2021) Antonio Ieni et al. Journal of Personalized Medicine
- Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer
- (2020) Emily J. Faivre et al. NATURE
- Developing effective combination therapy for pancreatic cancer: an overview
- (2020) Aubrey L. Miller et al. PHARMACOLOGICAL RESEARCH
- NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex
- (2020) Noelle M. Olson et al. BIOCHEMISTRY
- Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
- (2020) Shaokun Shu et al. MOLECULAR CELL
- Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation
- (2020) Omer Gilan et al. SCIENCE
- The Speckled Protein (SP) Family: Immunity’s Chromatin Readers
- (2020) Isabella Fraschilla et al. TRENDS IN IMMUNOLOGY
- The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain
- (2020) Julio C. Sanchez et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- “The emerging role of BET inhibitors in Breast Cancer”
- (2020) A. Andrikopoulou et al. BREAST
- BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells
- (2020) Hye In Cho et al. CELL DEATH AND DIFFERENTIATION
- A Phase 1b/2a Study of the Pan-BET Bromodomain Inhibitor ZEN-3694 in Combination with Enzalutamide in Patients with Metastatic Castration Resistant Prostate Cancer
- (2020) Rahul R. Aggarwal et al. CLINICAL CANCER RESEARCH
- Super-enhancer acquisition drives oncogene expression in triple negative breast cancer
- (2020) Ryan Raisner et al. PLoS One
- SMARCA2/4 PROTAC for Targeted Protein Degradation and Cancer Therapy
- (2020) Robert B. Kargbo ACS Medicinal Chemistry Letters
- TIF1 Proteins in Genome Stability and Cancer
- (2020) Roisin M. McAvera et al. Cancers
- BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression
- (2020) Thomas E. C. Cummin et al. Blood Advances
- Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain
- (2020) Jonathan T. Lloyd et al. JOURNAL OF MEDICINAL CHEMISTRY
- PML nuclear bodies and chromatin dynamics: catch me if you can!
- (2020) Armelle Corpet et al. NUCLEIC ACIDS RESEARCH
- A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets
- (2020) Masashi Watanabe et al. Communications Biology
- Sequential ubiquitination of p53 by TRIM28, RLIM, and MDM2 in lung tumorigenesis
- (2020) Jun-O Jin et al. CELL DEATH AND DIFFERENTIATION
- Current development of CBP/p300 inhibitors in the last decade
- (2020) Zhang-Xu He et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The bromodomain inhibitor PFI-3 sensitizes cancer cells to DNA damage by targeting SWI/SNF
- (2020) Daye Lee et al. MOLECULAR CANCER RESEARCH
- Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization
- (2020) Shravanti Mukherjee et al. Cell Death & Disease
- Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation
- (2020) Zhenyu Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy
- (2019) Gloria Manzotti et al. Cancers
- The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation
- (2019) Xi Jin et al. Science Advances
- Future of personalized therapy targeting aberrant signaling pathways in multiple myeloma
- (2019) Faiz Anwer et al. Clinical Lymphoma Myeloma & Leukemia
- Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP
- (2019) Beth E. Zucconi et al. BIOCHEMISTRY
- BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
- (2019) Xiaohong Zhao et al. CANCER CELL
- GSK2801, A BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer
- (2019) Samantha M. Bevill et al. MOLECULAR CANCER RESEARCH
- Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
- (2019) Fiona M. Behan et al. NATURE
- A chemical toolbox for the study of bromodomains and epigenetic signaling
- (2019) Qin Wu et al. Nature Communications
- BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
- (2019) Xiaofeng Wang et al. Nature Communications
- Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells
- (2019) Xueping Li et al. LIFE SCIENCES
- BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
- (2019) William Farnaby et al. Nature Chemical Biology
- Bromodomains: a new target class for drug development
- (2019) Andrea G. Cochran et al. NATURE REVIEWS DRUG DISCOVERY
- VDAC1 is regulated by BRD4 and contributes to JQ1 resistance in breast cancer
- (2019) Guochao Yang et al. Oncology Letters
- Mapping Bromodomains in breast cancer and association with clinical outcome
- (2019) Javier Pérez-Pena et al. Scientific Reports
- BET inhibitor bromosporine enhances 5-FU effect in colorectal cancer cells
- (2019) Xueyuan Cheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNA‑damaging chemotherapy agents and radiation
- (2019) Zhijian Duan et al. ONCOLOGY REPORTS
- TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
- (2019) Jiajing Chen et al. Nature Communications
- Non-canonical transcriptional consequences of BET inhibition in cancer
- (2019) Christopher Letson et al. PHARMACOLOGICAL RESEARCH
- Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone
- (2019) Carol Cho et al. Nature Communications
- Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay
- (2018) Tian Lu et al. ACTA PHARMACOLOGICA SINICA
- GSCALite: a web server for gene set cancer analysis
- (2018) Chun-Jie Liu et al. BIOINFORMATICS
- Structure-based discovery of selective BRPF1 bromodomain inhibitors
- (2018) Jian Zhu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
- (2018) Yan Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors
- (2018) Jeremy Lewin et al. JOURNAL OF CLINICAL ONCOLOGY
- Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
- (2018) Lara N. Gechijian et al. Nature Chemical Biology
- The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma
- (2018) A. Esteve-Arenys et al. ONCOGENE
- TRIM28 promotes cervical cancer growth through the mTOR signaling pathway
- (2018) Fan Li et al. ONCOLOGY REPORTS
- PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer
- (2018) David de Semir et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer
- (2018) Jose A. Guerrero-Martínez et al. Scientific Reports
- The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine
- (2018) Fang Xie et al. Scientific Reports
- Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
- (2018) Joshua Pan et al. Cell Systems
- Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis
- (2018) Gabriel J. Sandoval et al. MOLECULAR CELL
- Efficient proximity labeling in living cells and organisms with TurboID
- (2018) Tess C Branon et al. NATURE BIOTECHNOLOGY
- BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
- (2018) Malay Mandal et al. Nature Communications
- Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
- (2018) Ryan Raisner et al. Cell Reports
- Application of modified histone peptide arrays in chromatin research
- (2018) Rebekka Mauser et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
- (2018) Vittoria Zoppi et al. JOURNAL OF MEDICINAL CHEMISTRY
- BRD4 and Cancer: going beyond transcriptional regulation
- (2018) Benedetta Donati et al. Molecular Cancer
- Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
- (2018) Jean-Philippe Lambert et al. MOLECULAR CELL
- Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains
- (2018) Tyler Weaver et al. MOLECULES
- Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain
- (2018) Jamie C. Gay et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
- (2018) Gerard L Brien et al. eLife
- Inactivation of SMARCA2 by promoter hypermethylation drives lung cancer development
- (2018) Jixiang Wu et al. GENE
- Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain
- (2018) Chiara Zucchelli et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis
- (2017) Hector L. Franco et al. GENOME RESEARCH
- CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
- (2017) Liying Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Emerging therapies for acute myeloid leukemia
- (2017) Caner Saygin et al. Journal of Hematology & Oncology
- Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains
- (2017) Léa Bouché et al. JOURNAL OF MEDICINAL CHEMISTRY
- Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- (2017) Robin M Meyers et al. NATURE GENETICS
- WD40 repeat domain proteins: a novel target class?
- (2017) Matthieu Schapira et al. NATURE REVIEWS DRUG DISCOVERY
- Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
- (2017) Takao Fujisawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Repression of BET activity sensitizes homologous recombination–proficient cancers to PARP inhibition
- (2017) Lu Yang et al. Science Translational Medicine
- TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis
- (2017) Shigetsugu Hatakeyama TRENDS IN BIOCHEMICAL SCIENCES
- TOP2A , HELLS , ATAD2 , and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma
- (2017) Dong Chen et al. UROLOGY
- TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway
- (2017) Ziling Fang et al. Oncology Letters
- DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
- (2017) Emma A. Morrison et al. Nature Communications
- Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
- (2017) Alfonso Urbanucci et al. Cell Reports
- A Chemical Probe for the ATAD2 Bromodomain
- (2016) Paul Bamborough et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects
- (2016) J. Shahbazi et al. CLINICAL CANCER RESEARCH
- Bromodomain inhibitors and cancer therapy: From structures to applications
- (2016) Montserrat Pérez-Salvia et al. Epigenetics
- KAP1 is overexpressed in hepatocellular carcinoma and its clinical significance
- (2016) Yanying Wang et al. International Journal of Clinical Oncology
- Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C
- (2016) Xiaojie Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting the Breast Cancer Kinome
- (2016) Samantha M. Miller et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex
- (2016) Charlotte L. Sutherell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
- (2016) Laetitia J. Martin et al. JOURNAL OF MEDICINAL CHEMISTRY
- BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
- (2016) S. J. Hogg et al. MOLECULAR CANCER THERAPEUTICS
- ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes
- (2016) Na Li et al. MOLECULAR CELL
- Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
- (2016) Yuanyuan Li et al. MOLECULAR CELL
- Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
- (2016) Shaokun Shu et al. NATURE
- Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
- (2016) Anja F Hohmann et al. Nature Chemical Biology
- HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks
- (2016) Gregorio Alanis-Lobato et al. NUCLEIC ACIDS RESEARCH
- Epigenomic regulation of oncogenesis by chromatin remodeling
- (2016) R Kumar et al. ONCOGENE
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects
- (2016) Hidayatullah Munshi et al. OncoTargets and Therapy
- Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents
- (2016) Olaf Klingbeil et al. Cell Death & Disease
- ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia
- (2016) L. Zhu et al. Cancer Discovery
- The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus
- (2016) Ramiro Vázquez et al. Oncotarget
- ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication
- (2016) Seong Joo Koo et al. Oncotarget
- Targeting BET bromodomain proteins in solid tumors
- (2016) Vaibhav Sahai et al. Oncotarget
- Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression
- (2016) Sidra Majaz et al. Cell and Bioscience
- Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin
- (2016) Pavel Savitsky et al. Cell Reports
- Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer
- (2016) Fade Gong et al. PLoS Genetics
- Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
- (2016) Andrew R Conery et al. eLife
- Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study
- (2016) Céline Berthon et al. Lancet Haematology
- Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study
- (2016) Sandy Amorim et al. Lancet Haematology
- Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2
- (2015) Guillaume Poncet-Montange et al. BIOCHEMICAL JOURNAL
- Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
- (2015) S. Picaud et al. CANCER RESEARCH
- Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
- (2015) Jing Lu et al. CHEMISTRY & BIOLOGY
- ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker
- (2015) M.- J. Zhang et al. Clinical & Translational Oncology
- Phase I Population Pharmacokinetic Assessment of the Oral Bromodomain Inhibitor OTX015 in Patients with Haematologic Malignancies
- (2015) Elodie Odore et al. CLINICAL PHARMACOKINETICS
- BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation
- (2015) Y. Feng et al. EMBO JOURNAL
- Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination
- (2015) Fade Gong et al. GENES & DEVELOPMENT
- Recurrent translocation t(10;17)(p15;q21) in minimally differentiated acute myeloid leukemia results inZMYND11/MBTD1fusion
- (2015) Jasmijn D.E. de Rooij et al. GENES CHROMOSOMES & CANCER
- Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8
- (2015) Santanu Adhikary et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors
- (2015) Paul Bamborough et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B
- (2015) Peiling Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B
- (2015) Ludovic Drouin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
- (2015) Emmanuel H. Demont et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
- (2015) Natalie H. Theodoulou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
- (2015) Wylie S. Palmer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors
- (2015) F. Anthony Romero et al. JOURNAL OF MEDICINAL CHEMISTRY
- TRIM28 as an independent prognostic marker plays critical roles in glioma progression
- (2015) Zeng-Xin Qi et al. JOURNAL OF NEURO-ONCOLOGY
- BET inhibitor resistance emerges from leukaemia stem cells
- (2015) Chun Yew Fong et al. NATURE
- Histone reader BRWD1 targets and restricts recombination to the Igk locus
- (2015) Malay Mandal et al. NATURE IMMUNOLOGY
- Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer
- (2015) LE ZHENG et al. ONCOLOGY REPORTS
- CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
- (2015) Ariane Hammitzsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications
- (2015) E. Megan Flynn et al. STRUCTURE
- ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells
- (2015) Yang Luo et al. Gastroenterology Research and Practice
- Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells
- (2015) Yuichi Morozumi et al. Journal of Molecular Cell Biology
- Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery
- (2015) Yanai Zhan et al. Epigenetics & Chromatin
- ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma
- (2015) Camilla Krakstad et al. Oncotarget
- Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
- (2015) O. Fedorov et al. Science Advances
- ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis
- (2014) Wei-Na Wan et al. Asian Pacific Journal of Cancer Prevention
- BET bromodomain inhibitors—A novel epigenetic approach in castration-resistant prostate cancer
- (2014) Sarah E Lochrin et al. CANCER BIOLOGY & THERAPY
- Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer
- (2014) Jian Shi et al. CANCER CELL
- CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer
- (2014) Edmond Chipumuro et al. CELL
- AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
- (2014) Yuanyuan Li et al. CELL
- SnapShot: Histone Modifications
- (2014) He Huang et al. CELL
- ZMYND11
- (2014) Hong Wen et al. CELL CYCLE
- The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease
- (2014) Samuel Carlson et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
- (2014) Duncan A. Hay et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA Damage
- (2014) A. K. Jain et al. MOLECULAR AND CELLULAR BIOLOGY
- Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
- (2014) B. G. Wilson et al. MOLECULAR AND CELLULAR BIOLOGY
- Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
- (2014) W. Fiskus et al. MOLECULAR CANCER THERAPEUTICS
- ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
- (2014) Hong Wen et al. NATURE
- BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence
- (2014) Lei Gu et al. NATURE GENETICS
- The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
- (2014) Michael Waterfield et al. NATURE IMMUNOLOGY
- Affinity purification–mass spectrometry and network analysis to understand protein-protein interactions
- (2014) John H Morris et al. Nature Protocols
- BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
- (2014) Tomohiko Kanno et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
- (2014) Friederike Itzen et al. NUCLEIC ACIDS RESEARCH
- Loss of function of SWI/SNF chromatin remodeling genes leads to genome instability of human lung cancer
- (2014) HAI-TAO HUANG et al. ONCOLOGY REPORTS
- Overexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma
- (2014) Xiao Liu et al. PLoS One
- Histone H3.3 and cancer: A potential reader connection
- (2014) Fei Lan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching
- (2014) Martin Philpott et al. Epigenetics & Chromatin
- Correction: Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas
- (2014) David F. Vincent et al. PLoS Genetics
- Malignant genome reprogramming by ATAD2
- (2013) Fayçal Boussouar et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Diverse functions of PHD fingers of the MLL/KMT2 subfamily
- (2013) Muzaffar Ali et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cancers with wrong HATs: the impact of acetylation
- (2013) V. Di Cerbo et al. Briefings in Functional Genomics
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Tripartite Motif-containing 33 (TRIM33) Protein Functions in the Poly(ADP-ribose) Polymerase (PARP)-dependent DNA Damage Response through Interaction with Amplified in Liver Cancer 1 (ALC1) Protein
- (2013) Atul Kulkarni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)
- (2013) Motoko Unoki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) Long Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) Etienne De Braekeleer et al. LEUKEMIA & LYMPHOMA
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
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- (2013) Maria B. Raeder et al. PLoS One
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- JSME: a free molecule editor in JavaScript
- (2013) Bruno Bienfait et al. Journal of Cheminformatics
- Genome Regulation by Long Noncoding RNAs
- (2012) John L. Rinn et al. Annual Review of Biochemistry
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- (2012) Jonathan Seal et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
- (2012) C. J. Ott et al. BLOOD
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
- (2012) Panagis Filippakopoulos et al. CELL
- Comparative profiling of plasma proteome from breast cancer patients reveals thrombospondin-1 and BRWD3 as serological biomarkers
- (2012) Eui Jin Suh et al. EXPERIMENTAL AND MOLECULAR MEDICINE
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- (2012) Kyle J. Roux et al. JOURNAL OF CELL BIOLOGY
- Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions
- (2012) David S. Hewings et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lysine Succinylation and Lysine Malonylation in Histones
- (2012) Zhongyu Xie et al. MOLECULAR & CELLULAR PROTEOMICS
- The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3′-UTR truncation in round spermatids
- (2012) Binyamin D. Berkovits et al. NUCLEIC ACIDS RESEARCH
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- (2012) Zichong Li et al. NUCLEIC ACIDS RESEARCH
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- (2012) Haiying Li et al. PLoS One
- Identification of Combinatorial Patterns of Post-Translational Modifications on Individual Histones in the Mouse Brain
- (2012) Ry Y. Tweedie-Cullen et al. PLoS One
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- (2012) Zhijian Duan et al. PROSTATE
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- (2011) Monique Chambon et al. AMERICAN JOURNAL OF PATHOLOGY
- The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis
- (2011) Y. Mishima et al. BLOOD
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- (2011) Qiaoran Xi et al. CELL
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
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- (2011) Minjia Tan et al. CELL
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- (2011) Jian Yuan et al. CELL CYCLE
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- (2011) Peter Hemmerich CELL CYCLE
- ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
- (2011) Diana C Hargreaves et al. CELL RESEARCH
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- (2011) Cédric Hesling et al. EMBO REPORTS
- Bromodomains as therapeutic targets
- (2011) Susanne Muller et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- The Nucleosome Remodeling Factor
- (2011) Suehyb G. Alkhatib et al. FEBS LETTERS
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- (2011) Romain Aucagne et al. JOURNAL OF CLINICAL INVESTIGATION
- Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3
- (2011) R. Gamsjaeger et al. MOLECULAR AND CELLULAR BIOLOGY
- The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
- (2011) S. Rahman et al. MOLECULAR AND CELLULAR BIOLOGY
- Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities
- (2011) Eleonora Agricola et al. MOLECULAR CELL
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation
- (2011) Aruna Battu et al. NUCLEIC ACIDS RESEARCH
- The many blades of the β-propeller proteins: conserved but versatile
- (2011) Cammy K.-M. Chen et al. TRENDS IN BIOCHEMICAL SCIENCES
- Interaction of Propionylated and Butyrylated Histone H3 Lysine Marks with Brd4 Bromodomains
- (2010) Friederike Vollmuth et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Analysis of copy number variations of BS69 in multiple types of hematological malignancies
- (2010) Hong Yang et al. ANNALS OF HEMATOLOGY
- BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription
- (2010) M. T. Harte et al. CANCER RESEARCH
- ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2
- (2010) E. V. Kalashnikova et al. CANCER RESEARCH
- ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis
- (2010) Nathaniel T. Leachman et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes
- (2010) Jihong Chen et al. Epigenetics
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b
- (2010) Lei Zeng et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- BRD7 is a candidate tumour suppressor gene required for p53 function
- (2010) Jarno Drost et al. NATURE CELL BIOLOGY
- CDK8 is a positive regulator of transcriptional elongation within the serum response network
- (2010) Aaron J Donner et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
- (2010) Kyle M Miller et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers
- (2010) C Caron et al. ONCOGENE
- WD40 proteins propel cellular networks
- (2010) Christian U. Stirnimann et al. TRENDS IN BIOCHEMICAL SCIENCES
- PML Nuclear Bodies
- (2010) V. Lallemand-Breitenbach et al. Cold Spring Harbor Perspectives in Biology
- Androgen-Induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer
- (2009) J. X. Zou et al. CANCER RESEARCH
- ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors
- (2009) M. Ciro et al. CANCER RESEARCH
- FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
- (2009) Sirio Dupont et al. CELL
- Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
- (2009) Jorrit V Tjeertes et al. EMBO JOURNAL
- Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
- (2009) Jeanne Morinière et al. NATURE
- A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics
- (2009) A. M. Quinn et al. NUCLEIC ACIDS RESEARCH
- Trim24 targets endogenous p53 for degradation
- (2009) Kendra Allton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
- (2009) C. Choudhary et al. SCIENCE
- BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells
- (2008) Matthias D. Kaeser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes
- (2008) M. Ullah et al. MOLECULAR AND CELLULAR BIOLOGY
- Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
- (2008) Lei Zeng et al. STRUCTURE
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