Article
Oncology
Bo Gao, Xiumin Liu, Zhengjin Li, Lixian Zhao, Yun Pan
Summary: In breast cancer, the overexpression of EZH2 and NSD2 is associated with tumor grade and lymph node metastasis, and negatively correlates with RFS and DMFS. In TNBC, the EZH2/NSD2 axis may serve as a predictive marker for poor prognosis and disease progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Anuraag S. Parikh, Avishai Wizel, Daniel Davis, Armida Lefranc-Torres, Alejandro I. Rodarte-Rascon, Lauren E. Miller, Kevin S. Emerick, Mark A. Varvares, Daniel G. Deschler, William C. Faquin, Jon C. Aster, Derrick T. Lin, Bradley E. Bernstein, Yotam Drier, Sidharth V. Puram
Summary: This study utilized single-cell RNA sequencing to analyze salivary adenoid cystic carcinoma (ACC) at the cellular level, revealing expression heterogeneity in myoepithelial and luminal cells and differential expression of Notch signaling-related genes in myoepithelial cells. These findings may provide an explanation for the biphasic nature of low-and intermediate-grade ACC and offer insights for new therapeutic strategies.
Article
Oncology
Shun Wan, Yang He, Bin Zhang, Zhi Yang, Fang-Ming Du, Chun-Peng Zhang, Yu-Qiang Fu, Jun Mi
Summary: CDCA8 is significantly overexpressed in prostate cancer cells and predicts poor prognosis. High CDCA8 expression is associated with high-grade prostate cancer, and its silencing inhibits proliferation and migration of prostate cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Teppei Iwata, Anna S. Sedukhina, Manabu Kubota, Shigeko Oonuma, Ichiro Maeda, Miki Yoshiike, Wataru Usuba, Kimino Minagawa, Eleina Hames, Rei Meguro, Sunny Cho, Stephen H. H. Chien, Shiro Urabe, Sookhee Pae, Kishore Palanisamy, Toshio Kumai, Kazuo Yudo, Eiji Kikuchi, Ko Sato
Summary: This study identified upregulated pathways associated with short-term survival in a cohort of prostate cancer using bioinformatics analysis, with GRB2 being a novel biomarker predicting shorter survival in patients with aggressive prostate cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Sainan Liu, Bin Liu, Qian Zhao, Jikang Shi, Yulu Gu, Yanbo Guo, Yong Li, Yunkai Liu, Yi Cheng, Yichun Qiao, Yawen Liu
Summary: The study found that low FST expression is associated with poor prognosis of patients with TNBC, and FST exhibits heterogeneous roles in apoptosis in different subtypes of TNBC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang Yang, Hongjing Zang, Qiuyuan Wen, Yajie Zhang, Songqing Fan
Summary: P4HA1, as the core active catalytic portion of prolyl 4-hydroxylase, is up-regulated in non-small cell lung cancer (NSCLC). It serves as an independent prognosis biomarker in lung adenocarcinoma (LUAD) and influences tumor growth and metastasis by regulating cell cycle and invasion-related factors.
Article
Oncology
Huihui Li, Li Wang, Wei Zhang, Youting Dong, Yefeng Cai, Xiaoli Huang, Xubin Dong
Summary: This study investigates the functional role of PKMYT1 in breast cancer using bioinformatics methods, clinical samples, and experiments. The results show that PKMYT1 expression is higher in breast cancer tissues, particularly in advanced patients. PKMYT1 expression is associated with prognosis and is closely related to oncogenic or tumor suppressor gene variants. The study also reveals that PKMYT1 expression is upregulated in triple-negative breast cancer and is linked to immune cell infiltration in the tumor microenvironment. In vitro experiments demonstrate that inhibiting PKMYT1 expression inhibits proliferation, migration, and invasion of triple-negative breast cancer cells and induces apoptosis. Therefore, PKMYT1 may serve as a biomarker for prognosis and a therapeutic target for triple-negative breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiaonan Sheng, Huijuan Dai, Yueyao Du, Jing Peng, Rui Sha, Fan Yang, Liheng Zhou, Yanping Lin, Shuguang Xu, Yifan Wu, Wenjin Yin, Jinsong Lu
Summary: The study identifies the downregulation of lncRNA CARMN in TNBC, which predicts a better prognosis and enhanced cisplatin sensitivity in breast cancer. CARMN inhibits DNA replication and regulates MCM5 through miR143-3p, suggesting its potential role as a therapeutic target in TNBC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Neurosciences
Haitao Zheng, Hui Zhao, Gang Ye
Summary: The study found that miR-939-5p is significantly upregulated in glioma tissues and cell lines. The upregulation of miR-939-5p predicts a poor survival rate and may serve as an alternative prognostic indicator in glioma. High expression of miR-939-5p promotes proliferation, migration, and invasion in glioma cell lines.
NEUROMOLECULAR MEDICINE
(2021)
Article
Mathematical & Computational Biology
Yi Shi, Xiaoqian Huang, Zhaolan Du, Jianjun Tan
Summary: In this study, the heterogeneity within the tumor microenvironment of TNBC was investigated using single-cell RNA sequencing, and a dominant role of the hypoxic tumor subpopulation in angiogenesis- and metastasis-related signaling pathways was identified. A reliable risk score model was constructed for the prediction of overall survival in TNBC patients. ARTN and L1CAM were identified as important genes promoting angiogenesis and metastasis in TNBC, indicating poor prognosis.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Cell Biology
Lulu Le, Ji Luo, Haifang Wu, Ling Chen, Xiaoli Tang, Fen Fu
Summary: The study identified MYBL2 as significantly upregulated in endometrial cancer, with close associations with clinicopathological features and survival time. Inhibiting MYBL2 can suppress cell proliferation and induce apoptosis, providing a new therapeutic target for EC.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2021)
Article
Oncology
Paola Todeschini, Elisa Salviato, Chiara Romani, Vittoria Raimondi, Francesco Ciccarese, Federico Ferrari, Germana Tognon, Sergio Marchini, Maurizio D'Incalci, Laura Zanotti, Antonella Ravaggi, Franco Odicino, Enrico Sartori, Donna M. D'Agostino, Michele Samaja, Chiara Romualdi, Eliana Bignotti
Summary: In this study, miR-23a-3p was identified as a potential biomarker for chemoresistance and poor prognosis in HGSOC patients, with potential involvement in the platinum resistance pathway targeting APAF-1 gene. Evaluation of miR-23a-3p expression may guide clinical management of platinum-resistant patients, and the miR23a-3p/APAF1 axis could be a target for personalized medicine in HGSOC patients.
Article
Biochemistry & Molecular Biology
Bojana Uzelac, Ana Krivokuca, Snezana Susnjar, Zorka Milovanovic, Gordana Supic
Summary: The study reveals that HDAC7 mRNA overexpression is associated with invasive ductal carcinomas, high histologic grade, and high nuclear grade tumors in TNBC patients. TNBC subtypes have lower HDAC7 gene expression compared to ER+PR+HER2- tumors. However, HDAC7 overexpression predicts unfavorable survival in TNBC patients.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Endocrinology & Metabolism
Yinghe Sun, Wenhai Sun, Hui Hua, Jianhua Zhang, Qianqian Yu, Jueru Wang, Xiaomin Liu, Anbing Dong
Summary: The study found that miR-127 was upregulated in papillary thyroid cancer and correlated with poor prognosis. MiR-127 and TNM stage were considered as independent prognostic indicators for PTC. Overexpression of miR-127 enhanced cell proliferation, migration, and invasion of PTC by targeting REPIN1.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Immunology
Yinan Yao, Guangdie Yang, Guohua Lu, Jiani Ye, Luyun Cui, Zhu Zeng, Junjun Chen, Jianying Zhou
Summary: The interaction between immune cells and cytokines in the tumor microenvironment plays a crucial role in the development and prognosis of tumors. This study focuses on the role of Th22 cells and IL-22 in non-small-cell lung cancer (NSCLC) and its molecular mechanism. The study found that Th22 cells were enriched in the peripheral blood of NSCLC patients and correlated with tumor stage, lymph node metastasis, and clinical biomarkers. IL-22 was shown to antagonize the effects of chemotherapy and targeted drugs on NSCLC cell lines and promote tumor cell proliferation and growth. Additionally, IL-22 activated the JAK-STAT3/MAPK/AKT signaling pathway. These findings suggest that Th22 cells/IL-22 may act as negative immune regulators in lung cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)