Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
出版年份 2017 全文链接
标题
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
作者
关键词
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出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 4, Pages 246-262
出版商
Springer Nature
发表日期
2017-01-05
DOI
10.1038/nrm.2016.143
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex
- (2016) Hongjie Shen et al. CELL
- Progress in the Development of non-BET Bromodomain Chemical Probes
- (2016) Natalie H. Theodoulou et al. ChemMedChem
- Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells
- (2016) Lars Tögel et al. MOLECULAR CANCER THERAPEUTICS
- Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters
- (2016) Afsaneh Goudarzi et al. MOLECULAR CELL
- Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
- (2016) Yuanyuan Li et al. MOLECULAR CELL
- Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
- (2016) Shaokun Shu et al. NATURE
- Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk
- (2016) Sara Sdelci et al. Nature Chemical Biology
- The Taf14 YEATS domain is a reader of histone crotonylation
- (2016) Forest H Andrews et al. Nature Chemical Biology
- Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628
- (2016) A. Stathis et al. Cancer Discovery
- Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways
- (2016) Rolf Marschalek Annals of Laboratory Medicine
- Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
- (2016) Alison M. Kurimchak et al. Cell Reports
- Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma
- (2015) Ling Zhang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease
- (2015) Xiang-Jiao Yang BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Functions of BET proteins in erythroid gene expression
- (2015) Aaron J. Stonestrom et al. BLOOD
- Protein Lysine Acetylation by p300/CBP
- (2015) Beverley M. Dancy et al. CHEMICAL REVIEWS
- BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation
- (2015) Y. Feng et al. EMBO JOURNAL
- BET bromodomain inhibitors in leukemia
- (2015) Faisal Basheer et al. EXPERIMENTAL HEMATOLOGY
- Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination
- (2015) Fade Gong et al. GENES & DEVELOPMENT
- The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains
- (2015) Artyom A. Alekseyenko et al. GENES & DEVELOPMENT
- Recurrent translocation t(10;17)(p15;q21) in minimally differentiated acute myeloid leukemia results inZMYND11/MBTD1fusion
- (2015) Jasmijn D.E. de Rooij et al. GENES CHROMOSOMES & CANCER
- A novel recurrent EP300–ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia
- (2015) Y Gocho et al. LEUKEMIA
- An Interactive Database for the Assessment of Histone Antibody Specificity
- (2015) Scott B. Rothbart et al. MOLECULAR CELL
- Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation
- (2015) Benjamin R. Sabari et al. MOLECULAR CELL
- Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
- (2015) Philipp Rathert et al. NATURE
- BET inhibitor resistance emerges from leukaemia stem cells
- (2015) Chun Yew Fong et al. NATURE
- BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice
- (2015) Erica Korb et al. NATURE NEUROSCIENCE
- Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation
- (2015) Brianna J. Klein et al. NUCLEIC ACIDS RESEARCH
- Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC
- (2015) Cynthia Tallant et al. STRUCTURE
- A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications
- (2015) E. Megan Flynn et al. STRUCTURE
- Beating the odds: BETs in disease
- (2015) Chen-Yi Wang et al. TRENDS IN BIOCHEMICAL SCIENCES
- Overexpression of ANCCA/ATAD2 in endometrial carcinoma and its correlation with tumor progression and poor prognosis
- (2015) Pan Shang et al. TUMOR BIOLOGY
- Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells
- (2015) Yuichi Morozumi et al. Journal of Molecular Cell Biology
- Tumour suppressor TRIM33 targets nuclear β-catenin degradation
- (2015) Jianfei Xue et al. Nature Communications
- Expression alterations define unique molecular characteristics of spinal ependymomas
- (2015) Anbarasu Lourdusamy et al. Oncotarget
- TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome
- (2015) Yu Chen et al. Oncotarget
- Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4
- (2015) Bryce K. Allen et al. Scientific Reports
- Gene Fusions Associated with Recurrent Amplicons Represent a Class of Passenger Aberrations in Breast Cancer
- (2015) Shanker Kalyana-Sundaram et al. NEOPLASIA
- Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors
- (2014) Stuart W. J. Ember et al. ACS Chemical Biology
- Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer
- (2014) Jian Shi et al. CANCER CELL
- AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
- (2014) Yuanyuan Li et al. CELL
- BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K
- (2014) Sang Won Park et al. Cell Metabolism
- Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos
- (2014) Linya You et al. Epigenetics
- Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression
- (2014) Junya Kuroyanagi et al. FEBS LETTERS
- Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability
- (2014) Shrivatsav Pattabiraman et al. JOURNAL OF CELL BIOLOGY
- KAP-1 Promotes Resection of Broken DNA Ends Not Protected by -H2AX and 53BP1 in G1-Phase Lymphocytes
- (2014) A. T. Tubbs et al. MOLECULAR AND CELLULAR BIOLOGY
- The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
- (2014) Junwei Shi et al. MOLECULAR CELL
- BRD7, a Tumor Suppressor, Interacts with p85α and Regulates PI3K Activity
- (2014) Yu-Hsin Chiu et al. MOLECULAR CELL
- BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing
- (2014) Rui Guo et al. MOLECULAR CELL
- ANP32E is a histone chaperone that removes H2A.Z from chromatin
- (2014) Arnaud Obri et al. NATURE
- Space–time wiring specificity supports direction selectivity in the retina
- (2014) Jinseop S. Kim et al. NATURE
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
- (2014) Hong Wen et al. NATURE
- Identification of genomic alterations in oesophageal squamous cell cancer
- (2014) Yongmei Song et al. NATURE
- Mass-spectrometry-based draft of the human proteome
- (2014) Mathias Wilhelm et al. NATURE
- Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
- (2014) Pietro Ciceri et al. Nature Chemical Biology
- Genetic landscape of esophageal squamous cell carcinoma
- (2014) Yi-Bo Gao et al. NATURE GENETICS
- A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors
- (2014) Iacopo Petrini et al. NATURE GENETICS
- Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
- (2014) Katrina J. Falkenberg et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
- (2014) Eric Verdin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The growing landscape of lysine acetylation links metabolism and cell signalling
- (2014) Chunaram Choudhary et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- COSMIC: exploring the world's knowledge of somatic mutations in human cancer
- (2014) Simon A. Forbes et al. NUCLEIC ACIDS RESEARCH
- TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway
- (2014) L-H Zhang et al. ONCOGENE
- The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
- (2014) Robert Huether et al. Nature Communications
- Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity - a short report
- (2014) Hye Rim Oh et al. CELLULAR ONCOLOGY
- Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition
- (2014) Jessica E. Bolden et al. Cell Reports
- Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
- (2014) Raffaella Di Micco et al. Cell Reports
- BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
- (2014) Peter M. Brownlee et al. Cell Reports
- The Commonly Used PI3-Kinase Probe LY294002 Is an Inhibitor of BET Bromodomains
- (2013) Antje Dittmann et al. ACS Chemical Biology
- Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains
- (2013) Mathew P. Martin et al. ACS Chemical Biology
- A targeted mutational landscape of angioimmunoblastic T-cell lymphoma
- (2013) O. Odejide et al. BLOOD
- Tumor Suppressive Effects of Bromodomain-Containing Protein 7 (BRD7) in Epithelial Ovarian Carcinoma
- (2013) Young-Ae Park et al. CLINICAL CANCER RESEARCH
- Identification of driver genes in hepatocellular carcinoma by exome sequencing
- (2013) Sean P. Cleary et al. HEPATOLOGY
- Landscape of genomic alterations in cervical carcinomas
- (2013) Akinyemi I. Ojesina et al. NATURE
- The integrated landscape of driver genomic alterations in glioblastoma
- (2013) Veronique Frattini et al. NATURE GENETICS
- Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
- (2013) Jessica Okosun et al. NATURE GENETICS
- The mutational landscape of adenoid cystic carcinoma
- (2013) Allen S Ho et al. NATURE GENETICS
- Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
- (2013) Yuchen Jiao et al. NATURE GENETICS
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
- (2013) Z Zou et al. ONCOGENE
- Fusion of ZMYND8 and RELA Genes in Acute Erythroid Leukemia
- (2013) Ioannis Panagopoulos et al. PLoS One
- BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane
- (2013) Jude Alsarraj et al. PLoS One
- Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
- (2012) Y. W. Asmann et al. CANCER RESEARCH
- Small-Molecule Inhibition of BRDT for Male Contraception
- (2012) Martin M. Matzuk et al. CELL
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
- (2012) Panagis Filippakopoulos et al. CELL
- Bromodomain-dependent stage-specific male genome programming by Brdt
- (2012) Jonathan Gaucher et al. EMBO JOURNAL
- Prognostic relevance of BRD7 expression in colorectal carcinoma
- (2012) Wen-Jing Wu et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
- (2012) J. Liu et al. GENOME RESEARCH
- Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition
- (2012) Guangtao Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
- (2012) Martin Peifer et al. NATURE GENETICS
- The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis
- (2011) Y. Mishima et al. BLOOD
- A Poised Chromatin Platform for TGF-β Access to Master Regulators
- (2011) Qiaoran Xi et al. CELL
- Analysis of the Human Endogenous Coregulator Complexome
- (2011) Anna Malovannaya et al. CELL
- Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions
- (2011) Alexander J. Ruthenburg et al. CELL
- Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
- (2011) Minjia Tan et al. CELL
- Regulation of chromatin by histone modifications
- (2011) Andrew J Bannister et al. CELL RESEARCH
- Bromodomains as therapeutic targets
- (2011) Susanne Muller et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes
- (2011) Sebastian Schröder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3
- (2011) R. Gamsjaeger et al. MOLECULAR AND CELLULAR BIOLOGY
- Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities
- (2011) Eleonora Agricola et al. MOLECULAR CELL
- SAGA and ATAC Histone Acetyl Transferase Complexes Regulate Distinct Sets of Genes and ATAC Defines a Class of p300-Independent Enhancers
- (2011) Arnaud R. Krebs et al. MOLECULAR CELL
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
- (2011) Ignacio Varela et al. NATURE
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
- (2011) Dan R Robinson et al. NATURE MEDICINE
- Dual Function of Histone H3 Lysine 36 Methyltransferase ASH1 in Regulation of Hox Gene Expression
- (2011) Yujiro Tanaka et al. PLoS One
- Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes
- (2011) J. M. Lamonica et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
- (2011) B. Herquel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of fusion genes in breast cancer by paired-end RNA-sequencing
- (2011) Henrik Edgren et al. GENOME BIOLOGY
- Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors
- (2010) Nicholas A. Fairbridge et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
- (2010) Nishant Singhal et al. CELL
- ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis
- (2010) Nathaniel T. Leachman et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
- (2010) Nicolas Reynoird et al. EMBO JOURNAL
- NuA4-dependent Acetylation of Nucleosomal Histones H4 and H2A Directly Stimulates Incorporation of H2A.Z by the SWR1 Complex
- (2010) Mohammed Altaf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark
- (2010) A. S. Revenko et al. MOLECULAR AND CELLULAR BIOLOGY
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- TRIM24 links a non-canonical histone signature to breast cancer
- (2010) Wen-Wei Tsai et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- An assessment of histone-modification antibody quality
- (2010) Thea A Egelhofer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
- (2010) A. E. Burrows et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brd2disruption in mice causes severe obesity without Type 2 diabetes
- (2009) Fangnian Wang et al. BIOCHEMICAL JOURNAL
- ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors
- (2009) M. Ciro et al. CANCER RESEARCH
- FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
- (2009) Sirio Dupont et al. CELL
- Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse
- (2009) Enyuan Shang et al. DEVELOPMENTAL DYNAMICS
- A small-cell lung cancer genome with complex signatures of tobacco exposure
- (2009) Erin D. Pleasance et al. NATURE
- Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
- (2009) Jeanne Morinière et al. NATURE
- Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing
- (2009) Yonggang Zhou et al. NATURE CELL BIOLOGY
- Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
- (2009) C. Choudhary et al. SCIENCE
- The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte–embryo transition
- (2008) Dana L. Philipps et al. DEVELOPMENTAL BIOLOGY
- Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180
- (2008) Xuling Huang et al. DEVELOPMENTAL BIOLOGY
- Generation of mice with a conditional allele forTrim33
- (2008) Jieun Kim et al. GENESIS
- BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells
- (2008) Matthias D. Kaeser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
- (2008) Andrew Xiao et al. NATURE
- Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing
- (2008) Lei Zeng et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress
- (2008) J. Kimura et al. NUCLEIC ACIDS RESEARCH
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