Article
Multidisciplinary Sciences
Jie Li, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi-Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G. Mackintosh, Ricky D. Edmondson, Stephanie D. Byrum, Jason E. Farrar, Shenghui He, Ling Cai, Jian Jin, Alan J. Tackett, Deyou Zheng, Gang Greg Wang
Summary: This study reveals that the fusion gene ZMYND11-MBTD1 (ZM) induces AML in a subset of patients by activating the NuA4/TIP60 histone acetyltransferase complex. ZM directly regulates the expression of pro-leukemic genes, promoting the development of AML through sustaining an active chromatin state.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Maeva Devoucoux, Victoire Fort, Gabriel Khelifi, Joshua Xu, Nader Alerasool, Maxime Galloy, Nicholas Wong, Gaelle Bourriquen, Amelie Fradet-Turcotte, Mikko Taipale, Kristin Hope, Samer M. Hussein, Jacques Cote
Summary: The abnormal expression of ZMYND11-MBTD1 fusion gene in acute myeloid leukemia leads to mislocalization of the NuA4/TIP60 histone acetyltransferase complex, resulting in altered transcription of specific genes, particularly the MYC oncogene and alternative splicing.
Article
Medicine, General & Internal
Zhiling Zhang, Ling Xu, Zheng Hu, Baohua Yang, Jun Xu
Summary: This study found that microRNA-196b is highly expressed in ovarian cancer tissues and promotes the proliferation, invasion, and migration of ovarian cancer cells by targeting ZMYND11. In addition, dysregulation of microRNA-196b expression is associated with the malignant development of ovarian cancer.
Article
Genetics & Heredity
Stephanie Oates, Michael Absoud, Sushma Goyal, Sophie Bayley, Jennifer Baulcomb, Annemarie Sims, Amy Riddett, Katrina Allis, Charlotte Brasch-Andersen, Meena Balasubramanian, Renkui Bai, Bert Callewaert, Ulrike Hueffmeier, Diana Le Duc, Maximilian Radtke, Christian Korff, Joanna Kennedy, Karen Low, Rikke S. Moller, Jens Erik Klint Nielsen, Bernt Popp, Lina Quteineh, Gitte Ronde, Bitten Schoenewolf-Greulich, Amelle Shillington, Matthew R. G. Taylor, Emily Todd, Pernille M. Torring, Zeynep Tuemer, Georgia Vasileiou, T. Michael Yates, Christiane Zweier, Richard Rosch, M. Albert Basson, Deb K. Pal
Summary: The ZMYND11 gene is implicated in epilepsy, with varying seizure types and prognoses, but consistent neurodevelopmental deficits. There is no precise genotype-phenotype correlation for ZMYND11 variants, which are mostly de novo, and further research may reveal more about the underlying mechanisms.
Article
Cell Biology
Minh-Tuan Huynh, Cong Toai Tran, Madeleine Joubert, Claire Beneteau
Summary: The study reports a 7-year-old boy with developmental delay carrying the smallest de novo 10p15.3 microdeletion, involving the 5' UTR and the first 2 exons of ZMYND11. The findings contribute to expanding the clinical and mutational spectrum of ZMYND11 and confirming haploinsufficiency as the underlying disease mechanism.
CYTOGENETIC AND GENOME RESEARCH
(2021)